Francesca Milano

Carbohydrate- and heterocycle-based β-glucocerebrosidase inhibitors: State of the art and emerging relationship with cancer treatment

Francesca Milano, Francesca Clemente, Francesca Cardona, Andrea Goti et autres

Overcoming drug resistance remains a significant challenge in cancer treatment. The enzyme β-glucocerebrosidase (GCase) plays several roles in cellular processes, including carbohydrate metabolism and the hydrolysis of glucosides. Aberrant GCase activity has been linked to various diseases, and recent studies have implicated …

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A specific stem cell program and CD112 immunological axis dysfunctions underpinning monosomy 7-associated myeloid neoplasms

Anair Graciela Lema Fernandez, Carlotta Nardelli, Martina Quintini, Valeria Di Battista et autres

Monosomy 7 (-7) is occurring as isolated change or in complex karyotypes in 10-20% of myeloid neoplasms with poor prognosis. Although several genes mapping at chromosome 7 have been involved in pathogenetic mechanisms, the -7 molecular landscape is not fully elucidated. Using …

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The Leukemic Isocitrate Dehydrogenase (IDH) 1/2 Mutations Impair Myeloid and Erythroid Cell Differentiation of Primary Human Hematopoietic Stem and Progenitor Cells (HSPCs)

Sara Pierangeli, Serena Donnini, Valerio Ciaurro, Francesca Milano et autres

How hematopoietic stem and progenitor cell (HSPC) fate decisions are affected by genetic alterations acquired during AML leukemogenesis is poorly understood and mainly explored in animal models. Here, we study isocitrate dehydrogenase (IDH) gene mutations in the human model of HSPC and …

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The Leukemic IDH1/2 Mutations Impair Myeloid and Erythroid Cell Differentiation of Primary Human Hematopoietic Stem and Progenitor Cells (HSPC): Experimental Evidences and a Review of the Literature

Sara Pierangeli, Serena Donnini, Valerio Ciaurro, Francesca Milano et autres

How hematopoietic stem and progenitor cell (HSPC) fate decisions are affected by genetic alterations acquired during AML leukemogenesis is poorly understood and mainly explored in animal models. Here, we studied isocitrate dehydrogenases (IDH) genes mutations in the human model of HSPC and …

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Data from Comparison of Kinome Profiles of Barrett's Esophagus with Normal Squamous Esophagus and Normal Gastric Cardia

Jantine W.P.M. van Baal, Sander H. Diks, Ronald J. A. Wanders, Agnieskza M. Rygiel et autres

Abstract The precursor metaplastic mucosal lesion that predisposes for esophageal adenocarcinoma is Barrett's esophagus. Because the signal transduction events that occur in Barrett's esophagus are poorly understood, this study aimed at generating a comprehensive description of cellular kinase activity in Barrett's esophagus, …

Supplementary Tables 1-2 from Comparison of Kinome Profiles of Barrett's Esophagus with Normal Squamous Esophagus and Normal Gastric Cardia

Jantine W.P.M. van Baal, Sander H. Diks, Ronald J. A. Wanders, Agnieskza M. Rygiel et autres

Supplementary Tables 1-2 from Comparison of Kinome Profiles of Barrett's Esophagus with Normal Squamous Esophagus and Normal Gastric Cardia

Data from Comparison of Kinome Profiles of Barrett's Esophagus with Normal Squamous Esophagus and Normal Gastric Cardia

Jantine W.P.M. van Baal, Sander H. Diks, Ronald J. A. Wanders, Agnieskza M. Rygiel et autres

Abstract The precursor metaplastic mucosal lesion that predisposes for esophageal adenocarcinoma is Barrett's esophagus. Because the signal transduction events that occur in Barrett's esophagus are poorly understood, this study aimed at generating a comprehensive description of cellular kinase activity in Barrett's esophagus, …

Supplementary Tables 1-2 from Comparison of Kinome Profiles of Barrett's Esophagus with Normal Squamous Esophagus and Normal Gastric Cardia

Jantine W.P.M. van Baal, Sander H. Diks, Ronald J. A. Wanders, Agnieskza M. Rygiel et autres

Supplementary Tables 1-2 from Comparison of Kinome Profiles of Barrett's Esophagus with Normal Squamous Esophagus and Normal Gastric Cardia

GLUT-targeting multivalent iminoglyco-NPs with potential theranostic application

Francesca Milano, Camilla Matassini, Francesca Cardona, Andrea Goti et autres

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Theranostic Iminoglyco-NPs targeting the Blood Brain Barrier

Francesca Milano, Camilla Matassini, Francesca Cardona, Marco Marradi et autres

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From Serendipity to Rational Identification of the 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one Core as a New Chemotype of AKT1 Inhibitors for Acute Myeloid Leukemia

Andrea Astolfi, Francesca Milano, Deborah Palazzotti, Jose Manuel Brea et autres

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy whose prognosis is globally poor. In more than 60% of AML patients, the PI3K/AKTs/mTOR signaling pathway is aberrantly activated because of oncogenic driver alterations and further enhanced by chemotherapy as a mechanism of …

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AML-377 A “Designed” High-Throughput Drug Screening Strategy Identifies Aurora Kinase A Inhibitors as Promising Preclinical Candidates for the Treatment of NPM1-Mutated AML

Roberta Ranieri, Martin Neuenschwander, Sabrina Kleissle, Federica Mezzasoma et autres

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