Vincenzo De Tata

Trastuzumab cardiotoxicity and drug cardioprotection in healthy and cardiac dysfunction mouse models

Serena L’Abbate, Matilde Masini, Giuseppina Nicolini, Sabrina Marchetti et autres

Pre-existing cardiovascular disease is a recognised risk factor for cardiotoxicity in HER2-targeted therapies such as trastuzumab (TRZ), but few studies have addressed the impact of TRZ and the effects of cardioprotective drugs in pre-existing cardiac issues. This study examines the impact of …

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POS1427 ALTERED MITOCHONDRIAL BIOENERGETICS IN HYPOPHOSPHATASIA AND THE INFLUENCE OF EFZIMFOTASE ALFA

Dale P. DeVore, J. Ruanova, Walter C. Voegtli, Dallas Dunn et autres

Background: Hypophosphatasia (HPP) is a rare inherited metabolic disease caused by deficient tissue-nonspecific alkaline phosphatase (ALP) activity. HPP is characterized by skeletal and nonskeletal symptoms, including muscle weakness, although the etiology of nonskeletal manifestations is poorly understood. Objectives: We hypothesized that mitochondrial …

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Association of perfusate cytokine concentrations during liver graft ex situ normothermic perfusion to donor type and postoperative outcomes

Daniele Pezzati, Francesco Torri, Maria Franzini, E Balzano et autres

The use of the so-called extended criteria donors increases the number of grafts available for transplantation. Many studies reported their good outcomes but their use is debated due to increased risk of complications. Ex situ liver perfusion has reduced graft discard rate …

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Glutathione transferase omega 1-1 (GSTO1-1) can effect the inter-cell transfer of cisplatin resistance through the exosomal route

Simona Piaggi, Giulia Paties Montagner, Evelina Lorenzini, Matilde Masini et autres

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Dopamine-mediated autocrine inhibition of insulin secretion

Edoardo Ferrero, Matilde Masini, Marco Carli, Stefania Moscato et autres

The aim of the present research was to explore the mechanisms underlying the role of dopamine in the regulation of insulin secretion in beta cells. The effect of dopamine on insulin secretion was investigated on INS 832/13 cell line upon glucose and …

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Effects of sacubitril-valsartan on remodelling, fibrosis and mitochondria in a murine model of isoproterenol-induced left ventricular dysfunction

Giuseppe Vergaro, Annamaria Del Franco, Alessandro Carecci, Yu Fu Ferrari Chen et autres

BACKGROUND: Sacubitril/valsartan has been demonstrated to promote left ventricular (LV) reverse remodelling and improve outcomes in patients with heart failure (HF) with reduced ejection fraction (EF). Its molecular and tissue effects have not been fully elucidated yet, due to the paucity of …

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Sequential Normothermic Regional Perfusion and End-ischemic Ex Situ Machine Perfusion Allow the Safe Use of Very Old DCD Donors in Liver Transplantation

Francesco Torri, E Balzano, Fabio Melandro, Paolo Maremmani et autres

BACKGROUND: In Italy, 20 min of continuous, flat-line electrocardiogram are required for death declaration. Despite prolonged warm ischemia time, Italian centers reported good outcomes in controlled donation after circulatory death (cDCD) liver transplantation by combining normothermic regional and end-ischemic machine perfusion (MP). …

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Perfusate cytokines concentrations during liver grafts ex-situ normothermic perfusion (DCDNet Study)

Paola Vacca, Daniele Pezzati, Jessica Bronzoni, Caterina Martinelli et autres

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Exosomal Glutathione S-transferase Omega-1 (GSTO1-1) Can Effect the Inter-Cell Transfer of Cisplatin Resistance.

Simona Piaggi, Giulia Paties Montagner, Vincenzo De Tata, Alessandro Corti et autres

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Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review

Francesco Mazziotta, Gabriele Buda, Maria Livia Del Giudice, Enrico Orciuolo et autres

Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected; however, it is believed that many cases of amyloidosis are misrecognized due to the fact that its signs …

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β-Cells Different Vulnerability to the Parkinsonian Neurotoxins Rotenone, 1-Methyl-4-phenylpyridinium (MPP+) and 6-Hydroxydopamine (6-OHDA)

Marco Carli, Francesca Vaglini, Eleonora Risaliti, Gianluca Citi et autres

Neurotoxins such as rotenone, 1-methyl-4-phenylpyridinium (MPP+) and 6-hydroxydopamine (6-OHDA) are well known for their high toxicity on dopaminergic neurons and are associated with Parkinson’s disease (PD) in murine models and humans. In addition, PD patients often have glucose intolerance and may develop …

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Mast Cells and the Pancreas in Human Type 1 and Type 2 Diabetes

Matilde Masini, Mara Suleiman, Michela Novelli, Lorella Marselli et autres

Mast cells are highly differentiated, widely distributed cells of the innate immune system, that are currently considered as key regulators of both innate and adaptive immunity. Mast cells play a key role in health and survival mechanisms, especially as sentinel cells that …

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