Xiaoqiao Zhou

Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes

Federico Abascal, Reyes Acosta, Nicholas J. Addleman, Jessika Adrian et autres

In the version of this article initially published, two members of the ENCODE Project Consortium were missing from the author list. Rizi Ai (Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA) and Shantao Li (Program in …

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Author Correction: Perspectives on ENCODE

Federi Bronwen co Abascal, Reyes Acosta, Nicholas J. Addleman, Jessika Adrian et autres

In this Article, the authors Rizi Ai (Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA) and Shantao Li (Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA) were mistakenly omitted from the ENCODE …

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Effects of imbalance of mineral elements on peripheral neutrophil metabolism in sheep

Di Wang, Qi-Jun Zhou, Ming Ji, Xiaoqiao Zhou et autres

The imbalance of mineral element homeostasis in animals is common, causing animal immune dysfunction. Ten female sheep were randomly selected and injected with 4% (w/v) Na2EDTA through a central venous catheter to establish the mineral element imbalance model, then divided into control …

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Confirmation and variability of the Allee effect in Dictyostelium discoideum cell populations, possible role of chemical signaling within cell clusters

Igor Šegota, Matthew Edwards, Arthur C. Campello, Brendan Rappazzo et autres

Abstract In studies of the unicellular eukaryote Dictyostelium discoideum , many have anecdotally observed that cell dilution below a certain ‘threshold density’ causes cells to undergo a period of slow growth (lag). However, little is documented about the slow growth phase and …

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574 A deep learning classifier for the analysis of tiger tail banding in trichothiodystrophy

Allen L. Ho, E.H. Rizza, Jack Jeskey, S. Folarin et autres

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Perspectives on ENCODE

Federico Abascal, Reyes Acosta, Nicholas J. Addleman, Jessika Adrian et autres

The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open …

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Expanded encyclopaedias of DNA elements in the human and mouse genomes

Federico Abascal, Reyes Acosta, Nicholas J. Addleman, Veena Afzal et autres

Abstract The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the Encyclopedia of DNA Elements (ENCODE) Project has expanded analysis …

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Relationship between CYP3A29 and pregnane X receptor in landrace pigs: Pig CYP3A29 has a similar mechanism of regulation to human CYP3A4

Yucheng He, Xiaoqiao Zhou, Xiaowen Li, Xiue Jin et autres

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Porcine interleukin-6 enhances the expression of CYP2C33 through a constitutive androstane receptor/retinoid X receptor-mediated pathway

Lixia Xie, Yucheng He, Xiaoqiao Zhou, Xiaowen Li et autres

Cytochrome P450, which is expressed in humans and other animals, is a superfamily of drug-metabolizing enzymes that play important roles in the metabolism of endogenous and xenobiotic substrates via oxidation, peroxidation and reduction. Of endogenous substrates, interleukin (IL)-6 is a crucial cytokine …

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Relationship between CYP3A29 and pregnane X receptor in landrace pigs: Pig CYP3A29 has a similar mechanism of regulation to human CYP3A4 Toxicology & pharmacology

Yucheng He, Xiaoqiao Zhou, Xiaowen Li, Xiue Jin et autres

The objective of this study was to provide evidence of the validity of utilizing pigs as a model to study the regulation of human CYP3A4, with special emphasis on drug-drug interactions. We determined the mRNA expression and distribution of CYP3A and metabolic …

Cecropin B Represses CYP3A29 Expression through Activation of the TLR2/4-NF-κB/PXR Signaling Pathway

Xiaoqiao Zhou, Xiaowen Li, Xiliang Wang, Xiue Jin et autres

Cecropins are peptide antibiotics used as drugs and feed additives. Cecropin B can inhibit the expression of CYP3A29, but the underlying mechanisms remain unclear. The present study was designed to determine the mechanisms responsible for the effects of cecropin B on CYP3A29 …

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Relationship between zinc and the growth and development of young children

Shan Gao, Dan-Na Tu, H. Li, Xia Cao et autres

The purpose of this study was to evaluate the relationship between zinc and the growth and development of young children. The parents of 8102 young children were surveyed in person by a trained surveyor using structured questionnaires. The hair zinc concentration of …

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