Accès ouvert
2026
article
OpenAlex
Carlos Batlle-Recoder, Lorena Valverde-Estrella, M. Ferri, M Masó Serra et autres
Activation of macrophages with pro-inflammatory stimuli leads to the generation and secretion of large amounts of reactive oxygen species (ROS), which cause DNA double-strand breaks (DSBs). Here, the role of DNA polymerase μ (Polμ), a component of the non-homologous end-joining (NHEJ) DNA …
es
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Accès ouvert
2023
article
OpenAlex
Lisa Pöltl, Maksym Kitsera, Sandra Raffl, Stefan Schild et autres
The DNA-alkylating metabolite tilimycin is a microbial genotoxin. Intestinal accumulation of tilimycin in individuals carrying til+ Klebsiella spp. causes apoptotic erosion of the epithelium and colitis. Renewal of the intestinal lining and response to injury requires the activities of stem cells located …
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Accès ouvert
2022
article
OpenAlex
Carlos Sebastián, Neus Alfaraz Hernández
En las últimas cuatro décadas, China ha logrado el mayor desarrollo económico experimentado por una nación en toda la historia, al mismo tiempo que se convertía en el país más contaminante del mundo. Para remediarlo, en 2020 las autoridades chinas fijaron como …
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Accès ouvert
2022
article
OpenAlex
Carlos Sebastián, Christina M. Ferrer, Maria Paola Serra, Jee-Eun Choi et autres
Abstract Although reprogramming of cellular metabolism is a hallmark of cancer, little is known about how metabolic reprogramming contributes to early stages of transformation. Here, we show that the histone deacetylase SIRT6 regulates tumor initiation during intestinal cancer by controlling glucose metabolism. …
es, it, us, be
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Accès ouvert
2022
editorial
OpenAlex
Carlos Sebastián, Joaquim S. L. Vong, Manasi K. Mayekar, Krishna Seshu Tummala et autres
EDITORIAL article Front. Genet., 10 March 2022Sec.Epigenomics and Epigenetics https://doi.org/10.3389/fgene.2022.877538
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Accès ouvert
2022
article
OpenAlex
Tania Vico, Catrin Youssif, Fathema Zare, Mónica Comalada et autres
At inflammatory loci, pro-inflammatory activation of macrophages produces large amounts of reactive oxygen species (ROS) that induce DNA breaks and apoptosis. Given that M-CSF and GM-CSF induce two different pathways in macrophages, one for proliferation and the other for survival, in this …
es
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Accès ouvert
2021
article
OpenAlex
Lídia Fortuny, Carlos Sebastián
Beyond its role on the conversion of nutrients into energy and biomass, cellular metabolism is actively involved in the control of many physiological processes. Among these, it is becoming increasingly evident that specific metabolic pathways are associated with the phenotype of several …
es
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Accès ouvert
2021
article
OpenAlex
Carlos Sebastián, Neus Alfaraz Hernández
En menos de un año, China ha logrado contener la pandemia de la COVID-19 y retomar progresivamente la actividad económica a través de un ambicioso plan de estímulo fiscal, monetario y sectorial. Para ejecutar estas medidas de estímulo, las autoridades han recurrido …
Accès ouvert
2021
article
OpenAlex
Jee-Eun Choi, Carlos Sebastián, Christina M. Ferrer, Caroline A. Lewis et autres
us, it, es, il
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2020
dissertation
OpenAlex
Soler Chicacausa, Carlos Sebastián
Since the prehistoric era, humans have sought to generate visual impact on the use of utensils that adorned their figure, such as dyes, stones and bones. Artistic expressions were creating in humans a space of vanity and beautification, for which different types …
Accès ouvert
2020
article
OpenAlex
Doireann Joyce, Carlos Sebastián, Muhammad S.A. Tubassam, Stewart R. Walsh et autres
ie
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Accès ouvert
2020
article
OpenAlex
Carlos Sebastián, Neus Alfaraz Hernández
La epidemia de la COVID-19 se originó en China a finales de diciembre de 2019, convirtiéndose en una crisis global sin precedentes tres meses después. La crisis sanitaria generó un doble shock negativo de oferta y demanda en la economía china que …