Elisabeth Errazuriz-Cerda

Kremen1 dependence receptor induces SEC24C and ATG9A-dependent cell death

Sonia Brahim, Thomas Schott, Shiva Ghasemi-Firouzabadi, Ana Negulescu et autres

Among dependence receptors (DRs), which induce apoptosis when unbound by their cognate ligands, Kremen1 was initially reported to drive cancer cell death in the absence of DKK1. However, the precise mechanism of Kremen1-induced cell death remains unclear. In this study, we demonstrate …

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3D bioprinting of bioproduction cell lines

Laura Chastagnier, Lucie Essayan, Céline Thomann, Julia Niemann et autres

ABSTRACT Three-dimensional (3D) bioprinting presents a transformative approach to replicating vivo-like environments for mammalian cell cultures, offering potential advances in bioproduction and tissue engineering. In this study, we investigated the growth, metabolic activity, and structural organization of four mammalian cell lines (HEK, …

fr, de (code pays fourni par la source)

Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19

Flavien Picard, Takashi Nonaka, Edwige Belotti, Alexis Osseni et autres

Proteinopathies, such as amyotrophic lateral sclerosis (ALS), are marked by the accumulation of misfolded proteins that disrupt cellular processes. Eukaryotic cells have developed protein quality control systems to eliminate these aberrant proteins, but these systems often fail to differentiate between normal and …

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Kremen1 dependence receptor induces SEC24C and ATG9A-dependent autophagic cell death

Sonia Brahim, Thomas Schott, Ana Negulescu, Clara Geneste et autres

ABSTRACT Dependence receptors (DRs) induce cell death by apoptosis when unbound by their cognate ligands. Among them, Kremen1 was first described to induce cancer cell death in the absence of its ligand, DKK1. However, the precise mechanism of Kremen1-induced cell death remains …

fr, us, es (code pays fourni par la source)

Bioproduction Cell Lines 3d Bioprinting

Laura Chastagnier, Lucie Essayan, Céline Thomann, Julia Niemann et autres

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Bioproduction Cell lines 3D bioprinting

Laura Chastagnier, Lucie Essayan, Céline Thomann, Julia Niemann et autres

Three-dimensional (3D) bioprinting presents a transformative approach to replicating vivo-like environments for mammalian cell cultures, offering potential advances in bioproduction and tissue engineering. In this study, we investigated the growth, metabolic activity, and structural organization of four mammalian cell lines (HEK, MDCK, …

fr, de (code pays fourni par la source)

The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis

Julia Zibold, Lola Lessard, Flavien Picard, Lara A. Gruijs da Silva et autres

TAR DNA binding protein of 43 kDa (TDP-43)-positive inclusions in neurons are a hallmark of several neurodegenerative diseases including familial amyotrophic lateral sclerosis (fALS) caused by pathogenic TARDBP variants as well as more common non-Mendelian sporadic ALS (sALS). Here we report a …

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Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases

Sandrine Vadon‐Le Goff, Agnès Tessier, Manon Napoli, Cindy Dieryckx et autres

BMP-1/tolloid-like proteinases (BTPs) are major players in tissue morphogenesis, growth and repair. They act by promoting the deposition of structural extracellular matrix proteins and by controlling the activity of matricellular proteins and TGF-β superfamily growth factors. They have also been implicated in …

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Zinc Uptake by HIV-1 Viral Particles: An Isotopic Study

Olivia Guillin, Emmanuelle Albalat, Caroline Vindry, Elisabeth Errazuriz-Cerda et autres

Zinc, an essential trace element that serves as a cofactor for numerous cellular and viral proteins, plays a central role in the dynamics of HIV-1 infection. Among the viral proteins, the nucleocapsid NCp7, which contains two zinc finger motifs, is abundantly present …

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The Activation of the RIG-I/MDA5 Signaling Pathway upon Influenza D Virus Infection Impairs the Pulmonary Proinflammatory Response Triggered by Mycoplasma bovis Superinfection

Maria Gaudino, Adrien Lion, Eveline Sagné, Brandy Nagamine et autres

model of lung tissue to study the effects of IDV infection on bacterial superinfections. Our results show that IDV increases the susceptibility to the respiratory pathogen Mycoplasma bovis. In particular, IDV seems to activate immune pathways that inhibit the innate immune response …

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LipoParticles: a lipid membrane coating onto polymer particles to enhance the internalization in osteoblast cells

Allison Faure, Mathieu Varache, Mario Menéndez-Miranda, Virginie Dyon-Tafani et autres

LipoParticles, core–shell assemblies consisting of a polymer core coated by a lipid membrane, are promising carriers for drug delivery applications with intracellular targets.

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Immune-Mediated Rippling Muscle Disease Associated With Thymoma and Anti-MURC/Cavin-4 Autoantibodies

Juliette Svahn, Laurent Coudert, Nathalie Streichenberger, Alexandra Kraut et autres

OBJECTIVES: genes encoding Caveolin-3 or Cavin-1, respectively; a few series of patients with acquired autoimmune forms of RMD (iRMD) associated with AChR antibody-positive myasthenia gravis and/or thymoma have also been described. Recently, MURC/caveolae-associated protein 4 (Cavin-4) autoantibody was identified in 8 of …

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