Junfeng Liu

Genome sequencing based sequential diagnostic strategy improve diagnosed yield of pediatric genetic kidney disease: a national multicenter study

Chunyan Wang, Xiaoshan Tang, Xiuli Wang, Shuzhen Sun et autres

Genetic kidney disease (GKD) is a major cause of pediatric chronic kidney disease. Many patients remain genetically unresolved by exome sequencing (ES) and copy number variation (CNV) analysis. Genome sequencing (GS) enables a comprehensive detection of genetic variations. This study evaluates a …

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Despite improved overall stratification, the 9th edition stage IIIA category remains prognostically heterogeneous: insights from a T3N2a subgroup analysis

Nan Zhang, Junhong Liu, Jing Han, Junfeng Liu

The 9th edition TNM staging system refines N2 subclassification into single-station (N2a) and multi-station (N2b) metastases, leading to substantial stage migration within the previously heterogeneous stage IIIA category. While the 9th edition has demonstrated improved overall prognostic performance, it remains unclear whether …

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Integrated hypoxia and metabolic gene signature to predict clinical outcomes and therapeutic vulnerabilities in lung adenocarcinoma

Yuquan Ma, Mengmeng Yang, Zhitao Sun, Fei Liu et autres

Background: Immune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape of advanced non-small cell lung cancer (NSCLC), yet ~50% of lung adenocarcinoma (LUAD) patients exhibit primary or acquired resistance, underscoring the urgent need for predictive biomarkers. Hypoxia and metabolic reprogramming (HMR) are …

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Serum EphA4 is Associated with both Parenchymal Hematoma and Increased Blood–Brain Barrier Permeability after Ischemic Stroke

Yunxiu Huang, Xinmao Wu, Li Yu, Yanan Wang et autres

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Mapping the cerebral structural changes related to the multi-dimensional neuropsychiatric deficits in patients with ischemic thalamic stroke

C. Li, Chen Ye, Rui Sun, Ruosu Pan et autres

BACKGROUND: The thalamus serves as a central hub in the brain's neural network, playing a crucial role in sensory processing, cognitive functions, and emotional regulation. Although isolated thalamic strokes are relatively rare, their profound impact on cognitive and emotional outcomes highlights the …

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Predicting tumor response to TACE plus lenvatinib and PD-1 inhibitors for unresectable HCC: A multicenter observational study

Qingyun Xie, Bo Peng, Yong Zhao, Bin Liu et autres

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Comparative study of neoadjuvant chemoradiotherapy, chemotherapy, and chemoimmunotherapy for locally advanced esophageal squamous cell carcinoma

Likun Liu, Junhong Liu, Rong Yu, Shuai Zhang et autres

BACKGROUND: This study aimed to compare the efficacies of neoadjuvant chemoradiotherapy (NCRT), chemotherapy (NCT), and chemoimmunotherapy (NCIT) in patients with locally advanced esophageal squamous cell carcinoma (LAESCC). The primary objective was to assess the overall survival (OS) among the three treatment groups. …

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Transcranial laser therapy for acute ischaemic stroke

Haoyang He, Zhimeng Zhang, Hengshu Chen, Zhixuan Jiang et autres

RATIONALE: Ischaemic stroke is a leading cause of disability and death worldwide, but limited treatment options are available to improve its outcomes. Some studies have explored transcranial laser therapy in people with acute ischaemic stroke, but the benefits and harms of this …

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CircEGLN1 alleviates calcium oxalate-induced renal injury via miR-212-5p/STARD7 axis, offering a potential strategy for kidney stone prevention

Guangxin Zhong, Xue Zeng, Junfeng Liu, Tianjie Li et autres

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Expert Consensus on Subxiphoid and Subcostal Arch Thoracoscopic Resection for the Treatment of Thymoma

Xunliang Yin, Hongtao Duan, Zhengwei Zhao, Xiuyi Zhi et autres

Surgery is the primary treatment for thymoma. Although subxiphoid and subcostal arch thoracoscopic thymoma surgery is widely used, there is currently a lack of consensus regarding its use, nor have standards been established. Based on the surgical experience of many domestic thoracic …

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A commentary on restrictive vs. liberal fluid therapy

X.-H. Du, Zhenyu Zou, Junfeng Liu

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Effect of perioperative esketamine use on emergency delirium in children undergoing tonsillectomy and adenoidectomy: a systematic review and meta-analysis of randomized controlled trials

Junfeng Liu, Jinming Liu, Hong Sun, Chunhui Wang et autres

Background Emergence delirium(ED) is a common postoperative complication in children undergoing tonsillectomy and adenoidectomy under general anesthesia. There is no high-quality evidence on the relationship between esketamine and ED. The systematic review and meta-analysis was performed to investigate the effect of perioperative …

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