Ekaterina Alekseevna Shestakova

Rationale for the concept of combined initial therapy im type 2 diabetes mellitus

Ekaterina Alekseevna Shestakova

Glycemic targets remain a challenge for most patients with type 2 diabetes (T2D). In many cases, this is due to the patient’s non-compliance with the treatment regimen, insufficient self-monitoring, and delayed intensification of therapy. However, these challenges have been present for many …

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From Metabolically Healthy to Unhealthy Obesity Through Low-Grade Inflammation

Anastasia Voznesenskaya, Alyona Sorokina, M Shestakova, Ekaterina Alekseevna Shestakova et autres

Of the many clinical phenotypes of obesity, the most prevalent are metabolically "healthy" (MHO) and metabolically "unhealthy" (MUO) obesities, the latter being associated with a range of comorbidities, including type 2 diabetes mellitus (T2DM). The underlying causes of different obesity phenotypes and …

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From Metabolically Healthy to Unhealthy Obesity Through Low-Grade Inflammation

Anastasia Voznesenskaya, Alyona Sorokina, M Shestakova, Ekaterina Alekseevna Shestakova et autres

Of the many clinical phenotypes of obesity the most prevalent are metabolically “healthy” (MHO) and metabolically “unhealthy” obesity (MUO), the latter being associated with a range of comorbidities, in-cluding type 2 diabetes mellitus (T2DM). The underlying causes of different obesity phenotypes and …

Menopausal hormone therapy in patients with cardiovascular and metabolic diseases: an interdisciplinary Delphi consensus among Russian gynecologists, cardiologists, endocrinologists, gerontologists and geriatricians, phlebologists, and clinical pharmacologists

G. T. Sukhikh, Vladimir Nikolaevich Serov, Evgeny V. Shlyakhto, Ivan Ivanovich Dedov et autres

More than one million women in Russia enter menopause each year. The severe estrogen deficiency associated with this transition causes symptoms that significantly impair quality of life and contribute to an increased risk of cardiovascular and metabolic diseases. Menopausal hormone therapy (MHT) …

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Association of the gut microbiome and metabolome with the dynamics of laboratory parameters in individuals with type 2 diabetes and obesity after bariatric surgery

Ekaterina Alekseevna Shestakova, Natalia S. Klimenko, Elena V. Pokrovskaya, M. S. Sineokaya et autres

Background. It is known that the gut microbial community has a significant impact on the health of the host organism. It has been shown that changes in the composition and metabolic potential of the microbiota occur in people with obesity and diabetes …

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Weight regain and type 2 diabetes relapse in the long-term period after bariat ric surgery — who is at risk?

А. А. Voznesenskaya, A. P. Pershina-Miliutina, A. V. Aredov, A. O. Tomilova et autres

BACKGROUND : Bariatric surgery (BS) is one of the most effective treatment strategies for patients with morbid obesity and type 2 diabetes (T2DM). More than 80% of patients not only lose weight after BS, but also achieve T2DM remission. However, weight regain …

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The effect of AntiAGE-Biom probiotic on metabolic features in individuals with type 2 diabetes

Ekaterina Alekseevna Shestakova, Ф. У. Дзгоева, Sabina A. Nurmamedova, N. V. Frolkova et autres

Background. Despite the variety of antidiabetic therapies, many patients with type 2 diabetes (T2D) do not achieve optimal glycemic control. Therefore, there is a need to develop additional methods for managing T2D, including ones that regulate the gut microbiome. Aim. To assess …

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Impact of weight loss on GLP-1, glucagon and oxyntomodulin secretion in patients with obesity and type 2 diabetes

Ekaterina Alekseevna Shestakova, A. O. Tomilova, Margarita D. Samsonova, А. А. Voznesenskaya et autres

BACKGROUND : The effect of glucagon on metabolic processes is ambiguous: on the one hand, an excess of this hormone in the postprandial period increases glycemia, on the other hand, it can contribute to weight loss. In this regard, it is important …

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SUN-253 The Impact of Mibavademab, a Novel Leptin Receptor Agonist, on Metabolic Parameters in Individuals with Generalized Lipodystrophy

Rebecca J. Brown, Odelya E. Pagovich, Simona Podgrabinska, Jian M. Zhao et autres

Abstract Disclosure: R.J. Brown: Regeneron Pharmaceuticals, Chiesi Pharmaceuticals, Pfizer, Inc., Marea. O. Pagovich: Regeneron Pharmaceuticals. S. Podgrabinska: Regeneron Pharmaceuticals. J. Zhao: Regeneron Pharmaceuticals. R. Barrier: Regeneron Pharmaceuticals. B. Musser: Regeneron Pharmaceuticals. R. Dingman: Regeneron Pharmaceuticals. J. Mendell: Regeneron Pharmaceuticals. R.J. Sanchez: Regeneron …

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Clinical recommendations «Gestational diabetes mellitus» of the Russian Ministry of Health. Version of the year 2024

Ivan Ivanovich Dedov, Natalia G. Mokrysheva, Galina Afanas'evna Mel'nichenko, Ekaterina Anatol'evna Troshina et autres

The present article contains the newest ant the most actual version of clinical recommendations “Obesity” of the Russian Ministry of Health. This document has been confirmed for the period unti l 2026 year. Obestity — is chronic disease which is characterized by …

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The illusion of accuracy: a critical analysis of continuous glucose monitoring systems quality assessment methods

Marina Vladimirovna Shestakova, Valentina Aleksandrovna Peterkova, Gagik Radikovich Galstyan, Liudmila I. Ibragimova et autres

Continuous glucose monitoring (CGM) has been established as a method for self-assessment glucose levels in individuals with diabetes mellitus in the Russian Federation for more than 15 years. The main characteristics of CGM sensors are its’ accuracy and performance that ensure their …

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Thermogenesis and reduced lipid synthesis: one-anastomosis gastric bypass bariatric surgery 6-mo follow-ups in adipose tissue health context for type 2 diabetes

Iurii Stafeev, Margarita Yu. Agareva, Svetlana S. Michurina, Ekaterina Alekseevna Shestakova et autres

Today, bariatric surgery remains the most effective instrument for weight loss, glycemic control, and type 2 diabetes combat. Bariatric surgery causes mild stimulation of ADSC proliferation and suppresses white adipogenesis. ADSC-derived adipocytes exhibited lipid droplet fragmentation, activation of thermogenesis, and inhibition of …

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