Andrew Martin Tager

Durotaxis is a driver and potential therapeutic target in lung fibrosis and metastatic pancreatic cancer

Taslim Ahmed Al-Hilal, Maria-Anna Chrysovergi, Paula E. Grasberger, Fei Liu et autres

Abstract Durotaxis, cell migration along stiffness gradients, is linked to embryonic development, tissue repair and disease. Despite solid in vitro evidence, its role in vivo remains largely speculative. Here we demonstrate that durotaxis actively drives disease progression in vivo in mouse models …

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Myocardin‐related transcription factor contributes to renal fibrosis through the regulation of extracellular microenvironment surrounding fibroblasts

Yuta Yamamura, Norihiko Sakai, Yasunori Iwata, David Lagares et autres

Abstract Fibroblast accumulation and extracellular matrix (ECM) deposition are common critical steps for the progression of organ fibrosis, but the precise molecular mechanisms remain to be fully investigated. We have previously demonstrated that lysophosphatidic acid contributes to organ fibrosis through the production …

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Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model

Anna Axelsson Raja, Hiroko Wakimoto, Daniel M. DeLaughter, Daniel Reichart et autres

Myocardial fibrosis is a key pathologic feature of hypertrophic cardiomyopathy (HCM). However, the fibrotic pathways activated by HCM-causing sarcomere protein gene mutations are poorly defined. Because lysophosphatidic acid is a mediator of fibrosis in multiple organs and diseases, we tested the role …

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Screening for Inhibitors of YAP Nuclear Localization Identifies Aurora Kinase A as a Modulator of Lung Fibrosis

Yang Yang, Daniela Maria dos Santos, Lorena Pantano, Rachel S. Knipe et autres

Idiopathic pulmonary fibrosis is a progressive lung disease with limited therapeutic options that is characterized by pathological fibroblast activation and aberrant lung remodeling with scar formation. YAP (Yes-associated protein) is a transcriptional coactivator that mediates mechanical and biochemical signals controlling fibroblast activation. …

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Specialized transendothelial dendritic cells mediate thymic T-cell selection against blood-borne macromolecules

Elisabeth H. Vollmann, Kristin Rattay, Olga Barreiro, Aude Thiriot et autres

Abstract T cells undergo rigorous selection in the thymus to ensure self-tolerance and prevent autoimmunity, with this process requiring innocuous self-antigens (Ags) to be presented to thymocytes. Self-Ags are either expressed by thymic stroma cells or transported to the thymus from the …

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Author Correction: An injectable bone marrow–like scaffold enhances T cell immunity after hematopoietic stem cell transplantation

Nisarg J. Shah, Angelo S. Mao, Ting‐Yu Shih, Matthew D. Kerr et autres

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Innate Immune Reconstitution in Humanized Bone Marrow-Liver-Thymus (HuBLT) Mice Governs Adaptive Cellular Immune Function and Responses to HIV-1 Infection

Wilfredo Francisco Garcia-Beltran, Daniel T. Claiborne, Colby R. Maldini, Meredith Phelps et autres

Humanized bone marrow-liver-thymus (HuBLT) mice are a revolutionary small-animal model that has facilitated the study of human immune function and human-restricted pathogens, including human immunodeficiency virus type 1 (HIV-1). These mice recapitulate many aspects of acute and chronic HIV-1 infection, but exhibit …

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Endobronchial Optical Coherence Tomography: A Novel Method for the Microscopic Diagnosis of Usual Interstitial Pneumonia and Idiopathic Pulmonary Fibrosis

Rebecca A. Raphaely, Sreyankar Nandy, Ashok Muniappan, A. Shih et autres

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Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice

Sarah Alsamman, Stephanie A. Christenson, Amy Yu, Nadia M.E. Ayad et autres

Hepatic stellate cells (HSCs) drive hepatic fibrosis. Therapies that inactivate HSCs have clinical potential as antifibrotic agents. We previously identified acid ceramidase (aCDase) as an antifibrotic target. We showed that tricyclic antidepressants (TCAs) reduce hepatic fibrosis by inhibiting aCDase and increasing the …

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Endobronchial Optical Coherence Tomography for In Vivo Microscopic Diagnosis of Pulmonary Fibrosis

Lida P. Hariri, Sreyankar Nandy, Benjamin W. Roop, David C. Adams et autres

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In vivo diagnosis of idiopathic pulmonary fibrosis (IPF) using endobronchial OCT (Conference Presentation)

Sreyankar Nandy, Benjamin W. Roop, David C. Adams, Ashok Muniappan et autres

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive form of interstitial lung disease (ILD). High-resolution CT (HRCT) is currently used to identify macroscopic IPF features. However, for 50% of patients, ultimate diagnosis relies on microscopic features from invasive, high-risk surgical biopsies (SLBX). …

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Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney

Petra Šimić, Wondong Kim, Wen Liang Zhou, Kerry A. Pierce et autres

Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that controls blood phosphate levels by increasing renal phosphate excretion and reducing 1,25-dihydroxyvitamin D3 [1,25(OH)2D] production. Disorders of FGF23 homeostasis are associated with significant morbidity and mortality, but a fundamental understanding of what …

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