Guoling Huang

Entosis remodels the immune microenvironment of osteosarcoma by regulating macrophage polarization: An integrated study based on multi-omics data and in vitro experiments

Guoling Huang, Yongbo Xiao, Haitao Zhang, Ying Liu

BACKGROUND: Entosis is a non-apoptotic form of programmed cell death. Its clinical significance and mechanism of immune microenvironment remodeling in osteosarcoma remain poorly understood. METHODS: Multi-omics data from TARGET-OS and GEO were integrated with in vitro experiments. ssGSEA, WGCNA, scRNA-seq, pseudotime analysis, …

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VSIG4 suppresses antitumor T cell immunity via the SLC3A2-dependent metabolic–ionic checkpoint

Guoling Huang, Ruirui He, Wei Wang, Heping Wang et autres

Background Immune checkpoint blockade therapy aims to restore T-cell function within the tumor microenvironment (TME), eliciting durable antitumor responses. However, clinical response rates to PD-1/PD-L1 inhibitors remain limited, particularly in immunologically “cold” tumors such as pancreatic cancer, underscoring the need for alternative …

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HE4 drives PD-L1 expression in myeloid cells via IFN-γR-JAK-STAT3 signaling to promote tumor immune evasion

Bo Zeng, Yingying Zhou, Heping Wang, Panyin Shu et autres

Immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 have achieved clinical success, yet most patients fail to respond and many develop immune-related adverse events (irAEs). Although interferon gamma (IFN-γ) is considered the canonical driver of PD-L1 expression, regulation of PD-L1 in myeloid cells within …

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Myeloid DC-SIGN drives tumor immune evasion and resistance to PD-1 blockade through ICAM-2–ERM–mediated T-cell mechanosuppression

Ting Pan, T Z Wang, Jiaqi Wu, H Y Wang et autres

Abstract Resistance to PD-1–based immunotherapy remains a major challenge in cancer treatment, especially in immunologically “cold” tumors characterized by T-cell exclusion and impaired effector function. Tumor-associated myeloid cells are important mediators of this resistance, but whether they directly suppress T-cell immunity through …

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EPHB2 Suppresses Antiviral Immunity by Promoting MARCH8-mediated Autophagic Degradation of cGAS

Ruirui He, Xueni Lu, Changqun Liu, Ru Gao et autres

EPHA5 Links Viral Envelope Sensing to cGAS–STING Activation Through Tyrosine Phosphorylation

Lingyun Feng, Jianlin Zhou, Ruirui He, Jianan Liu et autres

EPHA5 regulates antifungal innate immunity by phosphorylating EPHB2 and Dectin-1

Ru Gao, Heping Wang, Zhihui Cui, Yanyun Du et autres

Invasive fungal infections (IFIs) have emerged as a significant health threat and cause approximately 3.75 million deaths per year globally. Understanding the detailed mechanism of the immune response to eliminate invasive fungal pathogens may help to provide new insights for the development …

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MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling

Heping Wang, Zhihui Cui, Wanwei Sun, Ming Yi et autres

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MYO1F regulates T-cell activation and glycolytic metabolism by promoting the acetylation of GAPDH

Zhihui Cui, Heping Wang, Feng Xiong, Chuyu Wu et autres

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Surgical Action Recognition and Prediction with Transformers

Guoling Huang

Surgical action recognition and prediction play a critical role in clinical decision support. The start-of-the-art surgical action analysis methods mainly focus on one of these two tasks. In this paper, an online surgical action recognition and prediction model to aid contextual decision-making …

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Changes of Serum Zinc-α2-Glycoprotein Level and Analysis of Its Related Factors in Gestational Diabetes Mellitus

Dongmei Xu, Jie You, Guixia Chen, Hongli Su et autres

Previous studies have discovered that zinc-α2-glycoprotein (ZAG) is related to insulin resistance and lipid metabolism. The aim of the study is to explore the change of serum ZAG and its related factors in gestational diabetes mellitus (GDM). Eighty newly diagnosed GDM patients …

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Changes of serum zinc-α2-glycoprotein level and analysis of its related factors in gestational diabetes mellitus:a cross-sectional study

Caiying Feng, Jie You, Guixia Chen, Hongli Su et autres

Abstract Background Previous studies have discovered that zinc-α2-glycoprotein is related to insulin resistance and lipid metabolism. The aim of the study is to explore the change of serum zinc-α2-glycoprotein(ZAG) and its related factors in gestational diabetes mellitus(GDM). Methods Eighty newly diagnosed GDM …

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