Valentina D’Angelo

Feasibility of a novel oncologist-led diagnostic algorithm for Lynch syndrome in colorectal cancer patients: The ItaLynch study.

Alberto Puccini, Eva Blondeaux, Francesca Bergamo, Linda Battistuzzi et autres

10618 Background: International guidelines recommend universal Lynch syndrome (LS) screening in colorectal cancer (CRC) using tumor mismatch repair deficiency (dMMR) testing. However, LS remains underdiagnosed worldwide, largely due to inconsistent referral for genetic counseling and germline testing. We report the final feasibility …

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Molecular Basis of Adenomatous Gastrointestinal Polyposis Syndromes: Role of Pathogenic and Benign Variants in Disease Onset

Francesca Cammarota, Valeria D’Agostino, Chiara Capasso, Francesca Duraturo et autres

Background: Colorectal cancer (CRC) is the third most diagnosed type of cancer and the second leading cause of cancer-related death. However, the increase in CRC incidence observed over the last 50 years has been accompanied by an overall reduction in mortality thanks …

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Mainstreaming the diagnosis of Lynch syndrome (LS) in colorectal cancer (CRC) patients: The ItaLynch study.

Alberto Puccini, Valentina Daprà, Linda Battistuzzi, Francesca Bergamo et autres

10580 Background: International guidelines recommend universal screening for LS through somatic DNA mismatch repair deficiency (dMMR) testing in CRC. However, LS remains largely underdiagnosed, often due to inconsistent referrals from oncologists to genetic counseling and germline testing. We report preliminary results of …

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286P Assessment of non-genetic factors with breast cancer risk in women BRCA carriers

Alessandra Calabrese, Mario Fordellone, Simona Buccolo, Caterina Vitulano et autres

T.06.2: GENETIC COUNSELING IN HEREDITARY GASTROINTESTINAL CANCER: A SINGLE INSTITUTIONAL EXPERIENCE AT NATIONAL CANCER INSTITUTE IN NAPLES

Valentina D’Angelo, Claudia Cardone, Matilde Pensabene, J. Ventriglia et autres

Efficacy of a novel hemostatic peptide gel (PuraStat) in preventing bleeding after endoscopic resection of large gastrointestinal lesions: a case series study

P. Andreozzi, M. Diaferia, Elena Di Girolamo, Corrado Civiletti et autres

Aims A novel synthetic self-assembling peptide (PuraStat; 3-D Matrix, Tokyo, Japan) has been introduced as a hemostatic agent [ 1 ]. This case series aimed to evaluate the clinical efficacy of PuraStat for the prevention of bleeding after endoscopic resection of large …

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The Role of Colonoscopy in the Management of Individuals with Lynch Syndrome: A Narrative Review

Valentina D’Angelo, Daniela Rega, P. Marone, Elena Di Girolamo et autres

The history of Lynch syndrome changed definitively in 2000, when a study published in Gastroenterology demonstrated a significant reduction in mortality among individuals with Lynch syndrome who undergo regular endoscopic surveillance. As a consequence of this clinical evidence, all scientific societies developed …

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Impact of endobiliary radiofrequency ablation on survival of patients with unresectable cholangiocarcinoma: a narrative review

Elena Di Girolamo, Andrea Belli, Alessandro Ottaiano, Vincenza Granata et autres

Cholangiocarcinoma (CCA) is a rare cancer originating from the biliary epithelium and accounts for about 3% of all gastrointestinal malignancies. Unfortunately, the majority of patients are not eligible for surgical resection at the time of diagnosis, because of the locally advanced stage …

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Immune-related thyroid dysfunctions during anti PD-1/PD-L1 inhibitors: new evidence from a single centre experience

Alice Nervo, Matteo Ferrari, Giovanni Gruosso, Enrica Migliore et autres

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Germline Variants in MLH1 and ATM Genes in a Young Patient with MSI-H in a Precancerous Colonic Lesion

Antonio Nolano, Giovanni Battista Rossi, Valentina D’Angelo, Raffaella Liccardo et autres

Lynch syndrome (LS) is an autosomal dominant inherited disorder that primarily predisposes individuals to colorectal and endometrial cancer. It is associated with pathogenic variants in DNA mismatch repair (MMR) genes. In this study, we report the case of a 16-year-old boy who …

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Thyroid hormone disorder and the heart: The role of cardiolipin in calcium handling

Valentina D’Angelo, Candela Martinez, Noelia Arreche, Ana María Balaszczuk et autres

Abstract The objective of this study was to evaluate whether alterations in thyroid status affect (1) haemodynamic parameters and echocardiographic measurements in the rat postnatal heart, and (2) calcium handling, contractility, relaxation and cardiolipin content in isolated rat cardiomyocytes. Sprague–Dawley rats aged …

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A multicenter randomized phase 4 trial comparing sodium picosulphate plus magnesium citrate vs. polyethylene glycol plus ascorbic acid for bowel preparation before colonoscopy. The PRECOL trial

Valentina D’Angelo, Maria Carmela Piccirillo, Massimo Di Maïo, Ciro Gallo et autres

Background Adequate bowel preparation before colonoscopy is crucial. Unfortunately, 25% of colonoscopies have inadequate bowel cleansing. From a patient perspective, bowel preparation is the main obstacle to colonoscopy. Several low-volume bowel preparations have been formulated to provide more tolerable purgative solutions without …

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