Mathias Rathe

Strength Training Exercises to Minimize Late Effects of Childhood Leukemia or Lymphoma Among Adolescents: A Multicenter Randomized Controlled Trial

Henrik Riel, Mathias KRISTIANSEN, Birgitte Klug Albertsen, Martin Kaj Fridh et autres

PURPOSE: Adolescent cancer survivors (ACS) often have persistent impairments in muscle strength, physical function, and quality of life (QoL). This study investigates the efficacy of strength training compared with low-load circuit training in increasing muscle strength over 16 weeks among ACS. METHODS: …

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Limited effect of surfactant protein D ablation on doxorubicin-induced intestinal toxicity in mice

Mathias Rathe, Sebastian Huth, Faisal Fazli, Mark Burton et autres

Introduction Surfactant protein (SP-D) is an anti-inflammatory host defense molecule, produced by epithelial cells and present on mucosal surfaces throughout the human and mouse body. In the present study, we investigated whether SP-D attenuates chemotherapy-induced gastrointestinal toxicity and inflammation in mice. Methods …

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Central nervous system aspergillosis in a child with medulloblastoma

Rasmus Møller Duus, Mathias Rathe, Line Raaby, Yasmin Kadija Hasan et autres

This case report and literature review of previously published cases describe the rare complication of cerebral aspergillosis in paediatric neuro-oncology patients. A boy in early childhood with high-risk medulloblastoma developed recurrent episodes of febrile neutropenia, persistent headache and cerebrospinal fluid (CSF) pleocytosis …

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Synchronous Acute Lymphoblastic Leukemia and Wilms Tumor: Report of a Case and Review of Previous Cases

Ariel M. Strand, Line W.L. Siggaard, Peder S. Wehner, Pernille W. Greisen et autres

BACKGROUND: Multiple primary cancers are rare in pediatric patients and are mostly metachronous. Synchronous primary malignancies are exceedingly rare and pose significant challenges. OBSERVATION: This case report and review of previous cases focus on synchronous acute lymphoblastic leukemia (ALL) and Wilms tumor …

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Late effects in children and adolescents after treatment for cancer

Cecilie Viola Buskbjerg, Christina Skeisvoll, Dorte; id_orcid 0000-0002-6598-9740 Hansen, Birgitte Klug Albertsen et autres

Improved survival among children and adolescents with cancer has increased the number of long-term survivors, including those who experience severe and complex late effects. Late effects may involve physical, cognitive, and psychological problems, as well as an elevated risk of secondary malignancies. …

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Plasma calprotectin to assess susceptibility to bloodstream infections during paediatric acute lymphoblastic leukaemia induction treatment

Johanna Vævest Nymann Eriksen, Silvia De Pietri, Mathias Rathe, H. Hasle et autres

Summary Chemotherapy‐induced neutropenia, monitored by peripheral blood absolute neutrophil count (ANC), increases the risk of bloodstream infections (BSIs). However, ANC may not reflect the total neutrophil population, as it omits neutrophils at extravascular sites. We therefore evaluated plasma calprotectin, a neutrophil‐derived protein, …

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Severe toxicity-free survival following acute lymphoblastic leukemia in patients aged 1–45 years: a Danish cohort study

Camilla Grud Nielsen, Bodil E Als-Nielsen, Birgitte Klug Albertsen, Ólafur Birgir Davídsson et autres

With increasing survival in acute lymphoblastic leukemia (ALL), long-term toxicities have become a critical aspect. A novel measure, designated Severe Toxicity-free survival (STFS), was developed through international consensus to integrate the most severe, symptomatic organ toxicities in outcome evaluation. This measure has …

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Delta-9-Tetrahydrocannabinol alleviates doxorubicin-induced weight loss but does not affect dextran sodium sulphate-induced colitis

M. J. Johansen, Marianne Andersen, Thomas Nørrelykke Nissen, Anders B. Nexoe et autres

BACKGROUND: Gastrointestinal mucositis is a common adverse effect of chemotherapy. Inflammatory bowel diseases (IBD) are a spectrum of chronic inflammatory disorders of the digestive tract. Mucositis and IBD/colitis are characterized by weight loss and intestinal inflammation. Previous animal studies suggest that the …

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Strength Training Exercises to minimise late Effects of childhood Leukaemia or lymphoma among adolescents – The STEEL study – protocol for a national multicentre randomised controlled trial

Henrik Riel, Mathias Vedsø Kristiansen, Birgitte Klug Albertsen, Martin Kaj Fridh et autres

Abstract Background Adolescent cancer survivors (ACS) often experience long-term impairments in muscle strength, physical function, and quality of life. Strength training may help address these deficits, but there is limited evidence from randomised trials. This study investigates the efficacy of progressive strength …

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Surgical Management of Paediatric Appendiceal Neuroendocrine Tumors: A 26-Year Danish Nationwide Retrospective Cohort Study

S. Jensen, Sara Giovannoni, Mona P. Ankerstjerne, Lene Gaarsmand Christensen et autres

BACKGROUND: Appendiceal neuroendocrine tumors (aNET) are incidental findings after appendectomy. Paediatric guidelines on surgical management are lacking, and the need for further surgery is debated. This retrospective cohort study aimed to describe incidence, patient and tumor characteristics, surgical management and outcomes, and …

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Sacrococcygeal Teratomas in Children and Adolescents – A Danish 26-Year Retrospective Cohort Study

Line Walther Lundbæk Siggaard, Mark Bremholm Ellebæk, Lene Gaarsmand Christensen, Jesper Sune Brok et autres

OBJECTIVE: To describe the incidence and assess the outcome and risk of long-term sequelae of sacrococcygeal teratomas (SCTs) in children and adolescents in Denmark. STUDY DESIGN: A nationwide retrospective register-based cohort study of all Danish children aged under 18 years diagnosed with …

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Portosystemic shunt as a cause of alternating ketotic hypoglycemia and hyperinsulinism in patients with associated anomalies

Henrik Thybo Christesen, Marianne Hørby Jørgensen, Susanne Christiansen Frevert, Pernille Wied Greisen et autres