Osama Abo Alrob

Harnessing Oxidative Stress to Kill Hepatocellular Carcinoma Cancer Cells: The Power of Methylselenic Acid and/or Pharmacological Ascorbate Combination—An In Vitro Study

Aseel O. Rataan, Amjad Z. Alrosan, Haneen A. Amawi, Lana K Rababah et autres

Background Hepatocellular carcinoma (HCC) is an aggressive and common liver cancer with high recurrence and late‐stage diagnosis. Despite multiple treatment options, their effectiveness is limited, especially in advanced stages. Hepatocellular cancer cells show elevated oxidative stress, which can be targeted therapeutically. Pharmacological …

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Exploring the Roles of Vitamins C and D and Etifoxine in Combination with Citalopram in Depression/Anxiety Model: A Focus on ICAM-1, SIRT1 and Nitric Oxide

Omar Gammoh, Aseel Ibrahim, Ala Yehya, Abdelrahim M. Alqudah et autres

The study of intercellular adhesion molecule-1 (ICAM-1) and SIRT1, a member of the sirtuin family with nitric oxide (NO), is emerging in depression and anxiety. As with all antidepressants, the efficacy is delayed and inconsistent. Ascorbic acid (AA) and vitamin D (D) …

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Obesity blunts insulin sensitivity improvements and attenuates strength gains following resistance training in nondiabetic men

Ramzi Al-Horani, Khaled M. Alsays, Osama Abo Alrob

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Investigating the fate and toxicity of green synthesized gold nanoparticles in albino mice

Nosaibah Akkam, Alaa A. A. Aljabali, Yazan Akkam, Osama Abo Alrob et autres

Objective: This study aimed to investigate the acute and chronic adverse effects of ∼50 nm (nanometer) gold nanoparticles (AuNPs) synthesized using Ziziphus zizyphus leaf extract in mice. Significance: Gold nanoparticles have shown promise for medical applications, but their safety and biocompatibility need …

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The Interplay of Exogenous and Endogenous Hydrogen Sulfide (H2S) in Maintaining Redox Homeostasis in Individuals with Low Ferritin Levels

Zaid Altaany, Almuthanna K. Alkaraki, Osama Abo Alrob, Omar Taani et autres

The primary objective of this study was to investigate the influence of living near a thermal spring and being exposed to hydrogen sulfide (H2S) gas, which lingers in the surrounding atmosphere, on the redox and lipid peroxidation status of individuals with low …

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Obesity Paradox among Heart Failure with Reduced Ejection Fraction Patients: A Retrospective Cohort Study

Osama Abo Alrob, Sowndramalingam Sankaralingam, Sayer I. Al-Azzam, Buthaina Nusairat et autres

Background and Objectives: There is consensus on the negative effects of obesity on the development of heart failure. However, several studies have suggested that obesity may have paradoxical survival benefits in heart failure patients. Therefore, the aim of this study is to …

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Synergistic Beneficial Effects of Resveratrol and Diet on High-Fat Diet-Induced Obesity

Osama Abo Alrob, Ramzi Al-Horani, Zaid Altaany, Mohammad B. Nusair

Introduction: Despite decades of research, obesity and its related medical complications remain a major health concern globally. Therefore, novel therapeutic strategies are needed to combat obesity and its numerous debilitating complications. Resveratrol (RES) has a potential therapeutic effect in obesity and diabetes …

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Public Attitudes toward Cancer and Cancer Patients: A Jordanian National Online Survey

Mohammad Al Qadire, Khaldoun Mousa Aldiabat, Enam Alsrayheen, Omar Al Omari et autres

Background: Public awareness and attitudes toward cancer and cancer patients are highly important in enhancing the effectiveness of cancer screening and early diagnosis programmes. This study aimed to explore the public attitudes toward cancer and cancer patients in Jordan. Method: A cross-sectional …

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Effect of Estrogen and Progesterone Hormones on the Expression of Angiotensin II Receptors in the Heart and Aorta of Male Rats

Bahaa Al‐Trad, Osama Abo Alrob, Yousf Jaradat, Mazhar Salim Al Zoubi et autres

BACKGROUND: Activation of the Angiotensin II type 1 receptor (AT1R) has been implicated in the pathogenesis of the cardiovascular disease, while activation of Angiotensin II type 2 receptor (AT2R) leads to effects that are opposite to those mediated by AT1R. The interaction …

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The Effect of Long-Term Second-Generation Antipsychotics Use on the Metabolic Syndrome Parameters in Jordanian Population

Osama Abo Alrob, Sayer I. Al-Azzam, Karem Hasan Alzoubi, Mohammad B. Nusair et autres

Objectives: The aim of this study was to determine the incidence of metabolic syndrome in patients treated with second-generation antipsychotics (SGAs). Methods: In this retrospective study, we reviewed patients’ electronic medical records (EMRs) of all patients who received one SGA for at …

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Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction

Wei Wang, Liyan Zhang, Pavan K. Battiprolu, Arata Fukushima et autres

Alterations in cardiac energy metabolism after a myocardial infarction contribute to the severity of heart failure (HF). Although fatty acid oxidation can be impaired in HF, it is unclear if stimulating fatty acid oxidation is a desirable approach to treat HF. Both …

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Caloric restriction limits fatty acid oxidation and improves cardiac function in heart failure associated with obesity

Qutuba G. Karwi, Liyan Zhang, Abhishek Kumar Gupta, Arata Fukushima et autres

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