A Walsh

The Support Needs and Current Practices of Public Health Nurses in the Republic of Ireland Who Provide Support to Breastfeeding Mothers: A Cross-Sectional Survey

A Walsh, Rachel McCluskey, Deirdre Cassidy, Gerardine McGoldrick et autres

Background: Breastfeeding continuation rates are low in Ireland. The Breastfeeding Observation and Assessment Tool (BOAT) was developed to assist public health nurses in assessing breastfeeding challenges; however, little is known of its actual usage, the level of training experienced or desired by …

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Health cognitions mediate physical (in)activity and walking in midlife women

A Walsh, Ellen E. A. Simpson

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Arboretum: Using a precision grammar for grammar checking in CALL

Emily M. Bender, Dan Flickinger, Stephan Oepen, A Walsh et autres

We present a tutorial system for language learners, using a computational grammar augmented with mal-rules for analysis, error diagnosis, and semantics-centered generation of corrected forms. Corrections are produced using a novel strategy of aligned generation. 1

Dietary Cholesterol Fails to Stimulate the Human Cholesterol 7α-Hydroxylase Gene (CYP7A1) in Transgenic Mice

Luis B. Agellon, Victor A. B. Drover, Sukhinder Kaur Cheema, G. Franck Gbaguidi et autres

Dietary cholesterol has been shown to have a stimulatory effect on the murine cholesterol 7alpha-hydroxylase gene (Cyp7a1), but its effect on human cholesterol 7alpha-hydroxylase gene (CYP7A1) expression in vivo is not known. A transgenic mouse strain harboring the human CYP7A1 gene and …

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Preliminary analysis of azoxymethane-induced colon tumorigenesis in mouse aggregation chimeras

Qian‐Shu Wang, A Walsh, Jennifer S. Goldsby, Alexandros Papanikolaou et autres

Inbred mice exhibit differential susceptibility to colon carcinogens. The following study addresses the possibility that differences are intrinsic to colonic mucosa (cell autonomous) or are mediated by extracolonic systemic factors (e.g. liver activation of carcinogens). Our approach was to construct mouse aggregation …

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Macrophage-targeted CTP:phosphocholine cytidylyltransferase (1–314) transgenic mice

Wei Dong Tang, A Walsh, Ira A. Tabas

CTP:phosphocholine cytidylyltransferase (CT) is a rate-limiting and complexly regulated enzyme in phosphatidylcholine (PC) biosynthesis and is important in the adaptation of macrophages to cholesterol loading. The goal of the present study was to use transgenesis to study the CT reaction in differentiated …

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Sterol Regulatory Element Binding Protein-1 Activates the Cholesteryl Ester Transfer Protein Gene in Vivobut Is Not Required for Sterol Up-regulation of Gene Expression

Roland A. Chouinard, Yi Luo, Timothy F. Osborne, A Walsh et autres

The plasma cholesteryl ester transfer protein (CETP) plays a central role in high density lipoprotein metabolism and reverse cholesterol transport. Plasma CETP levels are increased in response to dietary or endogenous hypercholesterolemia as a result of increased gene transcription in liver and …

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Human Cholesteryl Ester Transfer Protein Gene Proximal Promoter Contains Dietary Cholesterol Positive Responsive Elements and Mediates Expression in Small Intestine and Periphery While Predominant Liver and Spleen Expression Is Controlled by 5′-distal Sequences

Helena C.F. Oliveira, Roland A. Chouinard, Luis B. Agellon, Can Bruce et autres

The plasma cholesteryl ester transfer protein (CETP) facilitates the transfer of high density lipoprotein cholesteryl esters to other lipoproteins and appears to be a key regulated component of reverse cholesterol transport. Earlier studies showed that a CETP transgene containing natural flanking sequences …

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Increased prebeta-high density lipoprotein, apolipoprotein AI, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes.

Xian Li Jiang, Omar Luis Francone, Can Bruce, R W Milne et autres

Human plasma phospholipid transfer protein (PLTP) circulates bound to high density lipoprotein (HDL) and mediates both net transfer and exchange of phospholipids between different lipoproteins. However, its overall function in lipoprotein metabolism is unknown. To assess the effects of increased plasma levels …

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Alternative Splicing of the Human Cholesteryl Ester Transfer Protein Gene in Transgenic Mice

Tsuei-Ping Yang, Luis B. Agellon, A Walsh, Jan L. Breslow et autres

The plasma cholesteryl ester transfer protein (CETP) mediates the transfer of cholesteryl ester from high density lipoprotein to other lipoproteins. The human DETP gene produces two forms of mRNA, with or without exon 9 (E9)-derived sequences. To study the function and regulation …

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Profound induction of hepatic cholesteryl ester transfer protein transgene expression in apolipoprotein E and low density lipoprotein receptor gene knockout mice. A novel mechanism signals changes in plasma cholesterol levels.

Lori Masucci-Magoulas, Andrew S. Plump, Xian‐Cheng Jiang, A Walsh et autres

The plasma cholesteryl ester transfer protein (CETP) mediates the transfer of cholesteryl esters from HDL to other lipoproteins and is a key regulated component of reverse cholesterol transport. Dietary hypercholesterolemia results in increased hepatic CETP gene transcription and higher plasma CETP levels. …

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Cholesterol efflux potential of sera from mice expressing human cholesteryl ester transfer protein and/or human apolipoprotein AI.

Véronique Atger, Margarita de la Llera Moya, Mark J. Bamberger, O. L. Francone et autres

The ability of whole serum to promote cell cholesterol efflux and the relationships between apoprotein and lipoprotein components of human serum efflux have been investigated previously (de la Llera Moya, M., V. Atger, J.L. Paul, N. Fournier, N. Moatti, P. Giral, K.E. …

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