Diane Havard

Glyceryl trinitrate for treating hyperacute stroke: the Efficacy of Nitric Oxide in Stroke-2 (ENOS-2) feasibility randomised controlled trial

Lisa J Woodhouse, Iris Mhlanga, Amanda Buck, Lucy Gray et autres

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Desmopressin for patients with spontaneous intracerebral haemorrhage taking antiplatelet drugs (DASH): a UK-based, phase 2, randomised, placebo-controlled, multicentre feasibility trial

Michael Desborough, Rustam Al‐Shahi Salman, Simon Stanworth, Diane Havard et autres

BACKGROUND: The risk of death from spontaneous intracerebral haemorrhage is increased for people taking antiplatelet drugs. We aimed to assess the feasibility of randomising patients on antiplatelet drug therapy with spontaneous intracerebral haemorrhage to desmopressin or placebo to reduce the antiplatelet drug …

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Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage

Rustam Al‐Shahi Salman, Martin Dennis, Peter Sandercock, Cathie Sudlow et autres

Importance: The Restart or Stop Antithrombotics Randomized Trial (RESTART) found that antiplatelet therapy appeared to be safe up to 5 years after intracerebral hemorrhage (ICH) that had occurred during antithrombotic (antiplatelet or anticoagulant) therapy. Objectives: To monitor adherence, increase duration of follow-up, …

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Efficacy of Nitric Oxide in Stroke-2

Diane Havard, Philip M. Bath

Nitric oxide for preventing and reducing the severity of winter viral infections in residential and nursing homes

Diane Havard, Philip M. Bath

Remote ischaemic Conditioning After Stroke Trial - 3

Diane Havard, Timothy J. England

Desmopressin for treatment of stroke patients on antiplatelet therapy

Robert Gray, Diane Havard

Triple versus guideline antiplatelet therapy to prevent recurrence after acute ischaemic stroke or transient ischaemic attack: the TARDIS RCT

Philip M. Bath, Lisa J Woodhouse, Jason P. Appleton, Maia Beridze et autres

Background Two antiplatelet agents are better than one for preventing recurrent stroke after acute ischaemic stroke or transient ischaemic attack (TIA). Therefore, intensive treatment with three agents might be better still, providing it does not cause undue bleeding. Objective To compare the …

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Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial

Philip M. Bath, Lisa J Woodhouse, Jason P. Appleton, Maia Beridze et autres

BACKGROUND: Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy of intensive antiplatelet therapy (combined aspirin, clopidogrel, and dipyridamole) with …

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Ambulance-delivered transdermal glyceryl trinitrate versus sham for ultra-acute stroke: Rationale, design and protocol for the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) trial (ISRCTN26986053)

Jason P. Appleton, Polly Scutt, Mark Dixon, Harriet Howard et autres

RATIONALE: Vascular nitric oxide levels are low in acute stroke and donors such as glyceryl trinitrate have shown promise when administered very early after stroke. Potential mechanisms of action include augmentation of cerebral reperfusion, thrombolysis and thrombectomy, lowering blood pressure, and cytoprotection. …

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Post-stroke dysphagia: A review and design considerations for future trials

David Cohen, Christine Roffe, J. Beavan, B. Blackett et autres

Post-stroke dysphagia (a difficulty in swallowing after a stroke) is a common and expensive complication of acute stroke and is associated with increased mortality, morbidity, and institutionalization due in part to aspiration, pneumonia, and malnutrition. Although most patients recover swallowing spontaneously, a …

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