Jackson J. Hernandez

The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-implications for the toxic gain of function observed in ALS

Victor A. Streltsov, Katherine Ganio, Stewart D. Nuttall, Jackson J. Hernandez et autres

A subset of familial cases of amyotrophic lateral sclerosis (fALS) are caused by mutations to copper, zinc superoxide dismutase (Cu, Zn SOD1). Over 200 mutations to SOD1 that have been associated with fALS and the majority of these mutations are dominantly inherited. …

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The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-Implications for the toxic gain of function observed in ALS

Victor A. Streltsov, Katherine Ganio, Stewart D. Nuttall, Jackson J. Hernandez et autres

A subset of familial cases of amyotrophic lateral sclerosis (fALS) are caused by mutations to copper, zinc superoxide dismutase (Cu, Zn SOD1). There are over 200 mutations to SOD1 that have been associated with fALS and the majority of these mutations are …

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Exploring Interrupted Nazarov Cyclizations Using Tethered Sulfonamide Nucleophiles: Insights into Capture Pathways

Aleksa Milosavljevic, Jackson J. Hernandez, Patrycia K. Zybura, Alison J. Frontier

Abstract This manuscript describes a study of diverse reaction outcomes that stem from the ionization of aza‐alkynyl‐Prins adducts. Experimental results have demonstrated unexpected behavior in the nitrogen‐containing systems compared to the analogous oxygen derivatives derived from oxa‐Prins/halo‐Nazarov sequences. In‐depth experimental studies and …

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Alkynyl Halo-Aza-Prins Annulative Couplings

Jackson J. Hernandez, Alexandra P. Lawrie, Alison J. Frontier

High Resolution Image Download MS PowerPoint Slide This article is a comprehensive report describing our studies in the field of aza-alkynyl Prins chemistry, comparing and contrasting the different reaction partners and reactivities observed during method development. The synthetic strategies combine an alkynyl …

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CCDC 2174700: Experimental Crystal Structure Determination

Jackson J. Hernandez, Alison J. Frontier

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2174702: Experimental Crystal Structure Determination

Jackson J. Hernandez, Alison J. Frontier

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2195747: Experimental Crystal Structure Determination

Jackson J. Hernandez, Alison J. Frontier

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2174703: Experimental Crystal Structure Determination

Jackson J. Hernandez, Alison J. Frontier

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2174704: Experimental Crystal Structure Determination

Jackson J. Hernandez, Alison J. Frontier

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2176208: Experimental Crystal Structure Determination

Jackson J. Hernandez, Alison J. Frontier

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2174699: Experimental Crystal Structure Determination

Jackson J. Hernandez, Alison J. Frontier

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

Alkynyl Prins carbocyclization cascades for the synthesis of linear-fused heterocyclic ring systems

Jackson J. Hernandez, Alison J. Frontier

We report a Brønsted acid-catalyzed carbocyclization cascade, featuring condensation of an alcohol/sulfonamide with an aldehyde followed by an intramolecular three-component coupling involving an alkyne, an oxocarbenium/iminium ion, and an arene. A formal cycloaddition is embedded in the cationic cascade, which enables the …

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