Naama Karu

Tracking COVID‐19 Severity and Progression Through Amines and Lipid Mediators

Melissa Goris, Castilla Valdez, Lieke Lamont, Wei Yang et autres

Coronavirus disease 2019 (COVID-19) exhibits a broad spectrum of severity, ranging from mild to critical cases. To reduce mortality and costs, tailored early interventions for at-risk patients are essential. This study elucidates the association between longitudinal metabolomic profiles and COVID-19 severity and …

nl, au (code pays fourni par la source)

Interconnected influences of diet, gut microbiome, and metabolome on cognition across three metabolomics platforms

Rob Knight, Lora Khatib, Lucas Patel, Siamak MahmoudianDehkordi et autres

us, cn (code pays fourni par la source)

Exposome contribution to the brain metabolome: importance of body brain connection

Naama Karu, Haoqi Nina Zhao, Richa Batra, Matthias Arnold et autres

INTRODUCTION: Mounting evidence support exposome influences on brain function and health, complementing genome influences. Understanding the molecular imprint of exposome on brain metabolism and the biochemical communication between the body and brain can impact our fundamental understanding and treatment of neuropsychiatric diseases. …

au, us, de, br (code pays fourni par la source)

The Metabolome as a Readout for Adverse Social Exposome Influences on Human Health - A Roadmap for Modifiable Factors and Proactive Health

Nuanyi Liang, Siamak MahmoudianDehkordi, Margo B. Heston, Pallavi Kaushik et autres

The exposome factors, such as diet, lifestyle, microbiome, chemical exposures and social exposome, shapes human health beyond genetic influences, but the mechanisms remain only partially understood. Leveraging the Area Deprivation Index (ADI) of Neighborhood Atlas, a validated measure of the US social …

us, gb, au, ca (code pays fourni par la source)

A seven-year longitudinal study of the Alzheimer’s disease blood metabolome

Bharadwaj Marella, Patrick Weinisch, Josef J. Bless, Shannon L. Risacher et autres

Metabolic dysregulation is a hallmark of Alzheimer's disease (AD), yet the temporal nature of metabolite-phenotype associations remains poorly understood. We systematically evaluated 506 serum metabolites across 4,063 longitudinal samples from 1,430 participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI), applying cross-sectional single-timepoint …

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MiMeDB 2.0: the Human Microbial Metabolome Database for 2026

Ray Kruger, Eponine Oler, Sukanta Saha, Jenna Poelzer et autres

The Microbial Metabolome Database (MiMeDB) (https://mimedb.org) is a comprehensive, freely accessible resource linking human-associated microbes to the metabolites they produce, along with their connections to human health, disease, and diet. Since the release of MiMeDB 1.0 in 2023, the database has been …

ca, au, us (code pays fourni par la source)

Metabolic Signatures of Pulmonary Embolism in COVID-19: Insights from Longitudinal Intensive Care Unit Profiles

Mark Valdez, Malou Janssen, Zhengzheng Zhang, Lieke Lamont et autres

ABSTRACT Background Pulmonary embolism is a severe complication of COVID-19 infection, associated with a hypercoagulable state and heightened risk of blood clots. As SARS-CoV-2 has become endemic, understanding pulmonary embolism’s metabolic effects in COVID-19 patients is warranted. This study investigated the longitudinal …

nl, cz (code pays fourni par la source)

APOE genotype influences on the brain metabolome of aging mice – role for mitochondrial energetics in mechanisms of resilience in APOE2 genotype

Kamil Borkowski, Nuanyi Liang, Na Zhao, Matthias Arnold et autres

Alzheimer’s disease (AD) risk and progression are significantly influenced by APOE genotype with APOE4 increasing and APOE2 decreasing susceptibility compared to APOE3. While the effect of those genotypes was extensively studied on blood metabolome, less is known about their impact in the …

us, de, au, hk (code pays fourni par la source)

Metabolome informs about the chemical exposome and links to brain health

Matej Orešič, Naama Karu, Haoqi Nina Zhao, Arthur Moseley et autres

The metabolome is an intermediate phenotype, summarizing the profile of all small molecules (<1.5 kDa) in biospecimens. The metabolome provides a readout for the net influence of the chemical exposome, diet, gut microbiome, and genome on human health. Metabolic changes observed in …

fi, au, us, nl, ca, se (code pays fourni par la source)

APOE Genotype Influences on The Brain Metabolome of Aging Mice – Role for Mitochondrial Energetics in Mechanisms of Resilience in APOE2 Genotype

Kamil Borkowski, Nuanyi Liang, Na Zhao, Matthias Arnold et autres

Alzheimer's disease (AD) risk and progression are significantly influenced by APOE genotype with APOE4 increasing and APOE2 decreasing susceptibility compared to APOE3. While the effect of those genotypes was extensively studied on blood metabolome, less is known about their impact in the …

us, de, au, hk (code pays fourni par la source)

A Modified Mediterranean Ketogenic Diet reverses signatures and mitigates modifiable risk factors of Alzheimer’s disease

Annalise Schweickart, Kevin Huynh, Richa Batra, Bryan J. Neth et autres

Abstract Background Alzheimer’s disease (AD) is a neurodegenerative disorder with significant environmental factors, including diet, that influence its onset and progression. While the ketogenic diet (KD) holds promise in reducing metabolic risks and potentially affecting AD progression, only a few studies have …

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Correction to “Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene•GUT Fecal Stabilization”

Heidi Isokääntä, Lucas Pinto da Silva, Naama Karu, Teemu Kallonen et autres

Correction to: Comparative metabolomics and microbiome analysis of ethanol versus OMNImet/gene.GUT fecal stabilization (vol 96, pg 8893, 2024) 10.1021/acs.analchem.3c04436