Nancy A. Rebert

Novel Genetic Risk Variants and Clinical Predictors Associated With Primary Sclerosing Cholangitis in Patients With Ulcerative Colitis

Ming‐Hsi Wang, Jessica Friton, Nancy A. Rebert, Kelly Monroe et autres

INTRODUCTION: Patients with ulcerative colitis (UC) who are likely to have primary sclerosing cholangitis (PSC) should be identified because PSC can influence UC clinical behavior and outcomes.The aim of this study was to establish a model incorporating clinical and genetic risk predictors …

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A novel murine model of pyoderma gangrenosum reveals that inflammatory skin-gut crosstalk is mediated by IL-1β-primed neutrophils

Samreen Jatana, András K. Ponti, Erin E. Johnson, Nancy A. Rebert et autres

Pyoderma gangrenosum (PG) is a debilitating skin condition often accompanied by inflammatory bowel disease (IBD). Strikingly, ~40% of patients that present with PG have underlying IBD, suggesting shared but unknown mechanisms of pathogenesis. Impeding the development of effective treatments for PG is …

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Inhibition of pyrimidine synthesis in murine skin wounds induces a pyoderma gangrenosum-like neutrophilic dermatosis accompanied by spontaneous gut inflammation

Samreen Jatana, András K. Ponti, Erin E. Johnson, Nancy A. Rebert et autres

Abstract Pyoderma gangrenosum (PG) is a debilitating skin condition often accompanied by inflammatory bowel disease (IBD). Strikingly, ∼40% of patients that present with PG have underlying IBD, suggesting shared but unknown pathogenesis mechanisms. Impeding the development of effective treatments for PG is …

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Sa490 IMMATURE LOW-DENSITY NEUTROPHILS AS MEDIATORS OF PYODERMA GANGRENOSUM AND INFLAMMATORY BOWEL DISEASE PATHOGENESIS

Samreen Jatana, Nancy A. Rebert, Anthony P. Fernandez, Jean–Paul Achkar et autres

IMMATURE LOW-DENSITY NEUTROPHILS AS MEDIATORS OF PYODERMA GANGRENOSUM AND INFLAMMATORY BOWEL DISEASE PATHOGENESIS

Samreen Jatana, Nancy A. Rebert, Anthony Fernández, Jean–Paul Achkar et autres

IMMATURE LOW-DENSITY NEUTROPHILS AS MEDIATORS OF PYODERMA GANGRENOSUM AND INFLAMMATORY BOWEL DISEASE PATHOGENESIS

Samreen Jatana, Nancy A. Rebert, Anthony P. Fernandez, Jean–Paul Achkar et autres

Abstract Pyoderma gangrenosum (PG) is a debilitating skin condition characterized by deep, pus-filled, non-healing ulcers packed with neutrophils and is a common extraintestinal manifestation of inflammatory bowel disease (IBD). Strikingly, ~40% of people with an initial presentation of PG go on to …

Mutual Regulation of TLR/NLR and CEACAM1 in the Intestinal Microvasculature: Implications for IBD Pathogenesis and Therapy

Anja Schirbel, Nancy A. Rebert, Tammy Sadler, Gail West et autres

Background: Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) displays multiple activities, among which pathogen binding and angiogenesis are particularly prominent. These same functions are also exerted by Toll- and NOD-like receptors (TLRs and NLRs), which are critical mediators of innate immune responses. …

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1019 - The Influence of Vitamin D on Autophagy in Inflammatory Bowel Disease

Faris El-Khider, Nancy A. Rebert, Andre Bshara, Suha Abushamma et autres

Tu1795 - Integrating Clinical Factors and a Novel Genetic Risk Variant can Predict Primary Sclerosing Cholangitis Risk in Ulcerative Colitis Patients

Ming‐Hsi Wang, Jean–Paul Achkar, Richard H. Duerr, Omar Y. Mousa et autres

Integrating Genetic Risk Profiles With Clinical Predictors Can Predict Need for Early Surgery in Crohnʼs Disease: Presidential Poster

Ming‐Hsi Wang, Claudio Fiocchi, Stephan Ripke, Nancy A. Rebert et autres

Introduction: Clinicians currently have limited ability to identify Crohn's disease (CD) patients who are at highest risk of rapid disease progression and need for early surgery. The aim of this study is to develop a new model incorporating both clinical and genetic …

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Gene–gene and gene–environment interactions in ulcerative colitis

Ming‐Hsi Wang, Claudio Fiocchi, Xiaofeng Zhu, Stephan Ripke et autres

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Novel Gene-Gene and Gene-Environment Interactions in Ulcerative Colitis: ACG IBD Research Award

Ming‐Hsi Wang, Claudio Fiocchi, Xiaofeng Zhu, Stephan Ripke et autres

Purpose: Genome-wide association studies (GWAS) have identified 133 ulcerative colitis (UC)-associated genetic risk loci. However, the role of these genetic factors in clinical practice is not clearly defined. The aim of this study is to derive a UC-risk predictive model by combining …

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