Sehily Y. Jaimes

A Three-Factor Structure of Cognitive Functioning Among Unimpaired Carriers and Non-Carriers of Autosomal-Dominant Alzheimer’s Disease

Edmarie Guzmán‐Vélez, Sehily Y. Jaimes, Daniel Camilo Aguirre–Acevedo, Daniel J. Norton et autres

BACKGROUND: There is a need to find cognitive markers that can help identify individuals at risk for Alzheimer's disease (AD), and that can be used to reliably measure cognitive decline. OBJECTIVE: We tested whether a theoretically driven three-factor structure would characterize cognitive …

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Preferential degradation of cognitive networks differentiates Alzheimer’s disease from ageing

Jasmeer P. Chhatwal, Aaron P. Schultz, Keith A. Johnson, Trey Hedden et autres

Converging evidence from structural, metabolic and functional connectivity MRI suggests that neurodegenerative diseases, such as Alzheimer's disease, target specific neural networks. However, age-related network changes commonly co-occur with neuropathological cascades, limiting efforts to disentangle disease-specific alterations in network function from those associated …

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A-34A Three-Factor Structure of Cognitive Functioning Among Carriers and Non-Carriers of Autosomal-Dominant Alzheimer's Disease

Sehily Y. Jaimes, Daniel Camilo Aguirre–Acevedo, Daniel J. Norton, Dorene M. Rentz et autres

Objective: There is a need to identify neuropsychological markers that are sensitive to early detection and tracking of preclinical Alzheimer's disease (AD) decline. Impaired episodic memory is a hallmark of early AD, but whether decline occurs in non-memory aspects of cognition remains …

O4‐01‐06: Ab+ Clinically Normal Participants with Elevated Tau Show Greatest Decline in the Preclinical Alzheimer’s Disease Cognitive Composite

Elizabeth C. Mormino, Aaron P. Schultz, Bernard Jimmy Hanseeuw, Catherine E. Munro et autres

Aggregation of Aβ and Tau are thought to be critical components of the Alzheimer’s disease cascade. Using PET imaging to assess these hallmark pathologies, we sought to determine their joint contribution to cognitive decline during the preclinical stage of AD. Two hundred …

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P3‐322: Optimal Memory Performance in Older Adults is Associated with Differences in Hippocampal Volume and Amyloid Status at Baseline and Over 3 Years

Maria Dekhtyar, Rebecca Amariglio, Yakeel T. Quiroz, Aaron P. Schultz et autres

Age-related declines in memory have been well-documented. However, some individuals reach their 8 -10 decade while maintaining strong memory performance. We were interested in which demographic and biomarker variables distinguished individuals aged 75+ who score in the top 20 percentile for memory …

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P3‐309: Profiles of Cognitive Decline Associated with Biomarker‐Defined Preclinical Stages of Alzheimer’s Disease

Elizabeth C. Mormino, Rebecca England Amariglio, Aaron P. Schultz, Yakeel T. Quiroz et autres

Understanding the relationship between amyloidosis (Ab), neurodegeneration (ND), and cognition in clinically normal older adults is imperative as the field moves toward earlier identification and earlier intervention in Alzheimer’s disease. Previous research indicates that individuals with both Ab and ND show decline …

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IC‐P‐198: TAU and Amyloid PET Imaging in a Colombian Kindred with Autosomal‐Dominant Alzheimer's Disease

Yakeel T. Quiroz, Reisa Anne Sperling, Ana Y. Baena, Joseph F. Arboleda‐Velásquez et autres

Examining rare families with autosomal dominant mutations that cause early-onset Alzheimer's disease (AD) provides a unique model for studying the trajectory of AD-related pathology, especially in the preclinical stages. We used PET imaging to characterize the relation between amyloid burden and tau …

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O4‐01‐02: Tau and Amyloid Pet Imaging in a Colombian Kindred with Autosomal‐Dominant Alzheimer's Disease

Yakeel T. Quiroz, Reisa Anne Sperling, Ana Y. Baena, Joseph F. Arboleda‐Velásquez et autres

Examining rare families with autosomal dominant mutations that cause early-onset Alzheimer's disease (AD) provides a unique model for studying the trajectory of AD-related pathology, especially in the preclinical stages. We used PET imaging to characterize the relation between amyloid burden and tau …

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P3‐135: Clinical and neuroimaging predictors of psychological well‐being as measured by the purpose in life scale in cognitively normal older individuals

Sehily Y. Jaimes, Nancy J. Donovan, David C. Hsu, Alex S. Dagley et autres

Greater psychological well-being has been associated with positive health markers such as lower cardiovascular risk and higher REM sleep duration. Purpose in Life is one sub-scale of a six-component scale that defines a larger construct of psychological well-being. Post-mortem studies suggest that …

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P3‐217: Moderate caffeine consumption is associated with better memory scores in clinically normal older adults

Margaret P. Chute, David C. Hsu, Sarah E. Wigman, Catherine E. Munro et autres

Large epidemiological studies have shown a relationship between moderate caffeine and alcohol consumption and reduced rates of cognitive decline and dementia in older adults, using broad measures of global cognition and clinical decline. In this study, we investigated the relationship between multiple …

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P3‐104: Associations between subjective memory complaints and hippocampal volume in preclinical early‐onset Alzheimer's disease

Yakeel T. Quiroz, Rebecca England Amariglio, Daniel Camilo Aguirre–Acevedo, Sandra M. Opoka et autres

There is increasing evidence that subjective memory complaints (SMC) may be one of the earliest clinical signs of preclinical Alzheimer's disease (AD) in late-onset AD. Understanding the relevance of SMC in early-onset AD is relatively underexplored. Our goal was to examine self-reported …

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P4‐269: Relationships between baseline biomarkers and subsequent cognitive decline in cognitively unimpaired PSEN1 E280A mutation carriers from the colombian kindred with autosomal dominant Alzheimer's disease

Yakeel T. Quiroz, Hillary D. Protas, Kewei Chen, Auttawut Roontiva et autres

While brain imaging and cerebrospinal fluid (CSF) biomarkers have been used in the early detection and tracking of Alzheimer's disease (AD), their ability to predict subsequent clinical decline remains to be defined. In this study, we compared the ability of baseline PET …

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