Nabeela Karim

Granger causality connectivity analysis of persistent atrial fibrillation dynamics reveals posterior wall mechanistic insights

Joseph Barker, Arunashis Sau, Nikesh Bajaj, A. Jenkins et autres

Background Adjunctive posterior wall isolation (PWI) to pulmonary vein isolation (PVI) has not demonstrated convincing benefit during atrial fibrillation (AF) ablation. To provide mechanistic insight for null PWI trials we undertook Granger Causality (GC) analysis of non-contact left atrial electro-anatomical maps. Objective …

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Granger causality connectivity analysis of persistent atrial fibrillation dynamics reveals mechanistic insights into the posterior wall

Joseph Barker, Arunashis Sau, Nikesh Bajaj, A. Jenkins et autres

Abstract Background Pulmonary vein isolation (PVI) is the mainstay of ablation for atrial fibrillation (AF). Adjunctive posterior wall isolation (PWI) has not demonstrated convincing additional benefit. To provide mechanistic underpinnings as to why empirical PWI does not improve outcomes, we undertook Granger …

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Long-term outcomes of catheter ablation for atrial fibrillation in octogenarians

Nikola Kozhuharov, Nabeela Karim, António Creta, Lisa W. M. Leung et autres

BACKGROUND AND AIMS: Catheter ablation is superior to pharmacological therapy in controlling atrial fibrillation (AF). There are few data on the long-term outcome of AF ablation in octogenarian patients. This analysis aims to evaluate the outcome of AF ablation in octogenarians vs. …

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Left Atrial Appendage Pseudothrombus Is Associated With Stroke History in Patients With Atrial Fibrillation Undergoing Cardiac Computed Tomography

Edward David Nicol, Nabeela Karim, S Baleswaran, Ruth Owen et autres

Background In nonvalvular atrial fibrillation (NVAF), the left atrial appendage (LAA) is the source of thrombus in up to 90% of patients. LAA pseudothrombus (LAAPT), defined as a filling defect on the initial but not the 60‐second delayed acquisition on cardiovascular computed …

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Persistent and Recurrent Device-Related Thrombus After Left Atrial Appendage Closure

Jules Mesnier, Trevor Simard, Richard G. Jung, Kyle R. Lehenbauer et autres

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Recurrent cerebellar ischemic infarctions and stereotyped peri-ictal sympathetic responses in a near-SUDEP patient with cardiovascular risk factors

José L. Vega, Anna Carrasco, Nabeela Karim, Mark Stewart et autres

We report a 60-year-old woman who presented to the emergency department after experiencing a witnessed unknown onset bilateral tonic clonic seizure (GTCS) that culminated in cardiac arrest. A neurology consultant uncovered a years-long history of frequent episodic staring followed by confusion and …

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The long‐term outcomes of cardiac implantable electronic devices implanted via the femoral route

Samuel Griffiths, Jonathan M. Behar, Daniel B. Kramer, Mike T. Debney et autres

BACKGROUND: Conventional superior access for cardiac implantable electronic devices (CIEDs) is not always possible and femoral CIEDs (F-CIED) are an alternative option when leadless systems are not suitable. The long-term outcomes and extraction experiences with F-CIEDs, in particular complex F-CIED (ICD/CRT devices), …

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Novel aggregated multiposition noncontact mapping of atrial tachycardia in humans: From computational modeling to clinical validation

Rui Shi, Junaid A.B. Zaman, Zhong Chen, Xinwei Shi et autres

BACKGROUND: A novel aggregated multiposition noncontact mapping (AMP-NCM) algorithm is proposed to diagnose cardiac arrhythmias. OBJECTIVE: The purpose of this study was to computationally determine an accuracy threshold and to compare the accuracy and clinical utility of AMP-NCM to gold standard contact …

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Predictors of Device-Related Thrombus Following Percutaneous Left Atrial Appendage Occlusion

Trevor Simard, Richard G. Jung, Kyle Lehenbauer, Kerstin Piayda et autres

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Safety and acute clinical outcomes of atrial fibrillation catheter ablation in octogenarians: a multicentre evaluation with a matched younger cohort

Nabeela Karim, Nikola Kozhuharov, J Jarman, STEVE S. FURNISS et autres

Abstract Funding Acknowledgements Type of funding sources: None. OnBehalf Sven Knecht and the International Octogenarian AF ablation group Background Octogenarians are a fast-growing demographic with a high burden of atrial fibrillation (AF). There are limited data on procedural safety and acute outcomes …

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Initial experience of the High-Density Grid catheter in patients undergoing catheter ablation for atrial fibrillation

Nikolaos Papageorgiou, Nabeela Karim, James Henty Williams, Jason V. Garcia et autres

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Individualized ablation strategy to treat persistent atrial fibrillation: Core-to-boundary approach guided by charge-density mapping

Rui Shi, Zhong Chen, Michael Timothy Brian Pope, Junaid A.B. Zaman et autres

BACKGROUND: Noncontact charge-density mapping allows rapid real-time global mapping of atrial fibrillation (AF), offering the opportunity for a personalized ablation strategy. OBJECTIVE: The purpose of this study was to compare the 2-year outcome of an individualized strategy consisting of pulmonary vein isolation …

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