Jennifer C. Melvin

Canadian Recommendations for Germline Genetic Testing of Patients with Breast Cancer: A Call to Action

Evan W. Weber, Carlos González, Melanie Boucher, Andrea F. Eisen et autres

Pathogenic variants in breast cancer predisposition genes are associated with poor clinical outcomes but also offer an opportunity for more individualized therapeutic pathways. Given increasing knowledge, improvements in germline genetic testing efficiency, and the availability of novel systemic targeted treatment options, the …

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Abstract CT239: IND.241: A Canadian cancer trials group liquid-biopsy informed platform trial to evaluate treatment in CDK4/6-inhibitor resistant ER+/HER2- metastatic breast cancer

Moira Katherine Rushton, Dave W. Cescon, Nathalie LeVasseur, Michelle B. Nadler et autres

Abstract Introduction: The combination of CDK4/6 inhibitor+endocrine therapy (CDK4/6i+ET) is standard 1st-line (1L) systemic treatment for patients with ER+/HER2-negative metastatic breast cancer (MBC). Numerous agents are available / in development for subsequent lines of treatment. Circulating tumor DNA (ctDNA) via liquid biopsy …

ca (code pays fourni par la source)

Canadian Recommendations for Germline Genetic Testing of Patients with Breast Cancer: A Call to Action

Evan W. Weber, Carlos González, Melanie Boucher, Andrea F. Eisen et autres

Pathogenic variants in breast cancer predisposition genes are associated with poor clinical outcomes but also offer an opportunity for more individualized therapeutic pathways. Given increasing knowledge, improvements in germline genetic testing efficiency, and the availability of novel systemic targeted treatment options, the …

Secondary prophylaxis and specialist review compliance in paediatric patients with acute rheumatic fever and rheumatic heart disease in a Western Australian metropolitan setting

Adrian J. Tarca, Jennifer C. Melvin, Bradley R. MacDonald, A. Jeyaseelan et autres

AIM: Rheumatic heart disease (RHD), a consequence of acute rheumatic fever (ARF), continues to cause significant morbidity and mortality in susceptible young people. Secondary antibiotic prophylaxis is an effective strategy to prevent ARF recurrence and RHD progression. However, the proportion of patients …

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Glucose and lipoprotein biomarkers and breast cancer severity using data from the Swedish AMORIS cohort

Jennifer C. Melvin, Hans G. Garmo, Lars Holmberg, Niklas Hammar et autres

BACKGROUND: The lipid and glucose metabolisms are postulated as possible intermediary mechanisms in linking obesity and breast cancer (BC). Links between serum lipid and glucose biomarkers and BC risk has been observed in the Swedish Apolipoprotein MORtality RISk (AMORIS) cohort. We conducted …

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Serum Calcium and the Risk of Breast Cancer: Findings from the Swedish AMORIS Study and a Meta-Analysis of Prospective Studies

Wahyu Wulaningsih, Harkiran Sagoo, Mustafa Hamza, Jennifer C. Melvin et autres

To investigate the association between serum calcium and risk of breast cancer using a large cohort and a systematic review with meta-analysis. From the Swedish Apolipoprotein Mortality Risk (AMORIS) Study we included 229,674 women who had baseline measurements of serum total calcium …

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Erratum: Progression of breast cancer following locoregional ipsilateral recurrence: importance of interval time

Jennifer C. Melvin, Arnie D. Purushotham, Hans G. Garmo, Sarah E. Pinder et autres

Family history of breast cancer and its association with disease severity and mortality

Jennifer C. Melvin, Wahyu Wulaningsih, Zac Hana, Arnie D. Purushotham et autres

A family history (FH) of breast cancer (BC) is known to increase an individual's risk of disease onset. However, its role in disease severity and mortality is less clear. We aimed to ascertain associations between FH of BC, severity and BC-specific mortality …

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Progression of breast cancer following locoregional ipsilateral recurrence: importance of interval time

Jennifer C. Melvin, Arnie D. Purushotham, Hans G. Garmo, Sarah E. Pinder et autres

BACKGROUND: Studies comparing prognosis of breast cancer (BC) patients with and without locoregional recurrence (LR) present conflicting results. We aimed to improve our understanding of the impact of LR on prognosis by examining a large cohort of patients treated at Guy's and …

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Serum glucose and risk of cancer: a meta-analysis

Danielle Crawley, Lars Holmberg, Jennifer C. Melvin, Massimo F. Loda et autres

BACKGROUND: Raised serum glucose has been linked to increased risk of many solid cancers. We performed a meta-analysis to quantify and summarise the evidence for this link. METHODS: Pubmed and Embase were reviewed, using search terms representing serum glucose and cancer. Inclusion …

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Obesity and cancer: the role of vitamin D

Thurkaa Shanmugalingam, Danielle Crawley, Cecilia Bosco, Jennifer C. Melvin et autres

BACKGROUND: It is estimated that 20% of all cancer cases are caused by obesity. Vitamin D is thought to be one of the mechanisms underlying this association. This review aims to summarise the evidence for the mediating effect of vitamin D on …

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An investigation into the relationship between statins and cancer using population‐based data

Jennifer C. Melvin, Hans G. Garmo, Rhian Daniel, Thurkaa Shanmugalingam et autres

Background Results to date for the association between use of statins and prostate cancer (PCa) death in observational studies are inconsistent. We investigated the application of causal inference methods, which aim to address observational data as if they were from a randomised …

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