Hansel M. Greiner

Seizure outcomes after laser interstitial thermal therapy for pediatric extratemporal lobe epilepsy

Bryce S. Owen, Amber L. Gaulden, Torin Karsonovich, Hansel M. Greiner et autres

OBJECTIVE: Approximately one-third of patients with epilepsy develop drug-resistant epilepsy (DRE). Extratemporal lobe epilepsy (ETLE) represents 30%-40% of focal epilepsy cases. ETLE poses significant challenges in localization and treatment because these patients often have diffuse and complex epileptogenic networks. Laser interstitial thermal …

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Developmental disinhibition gates language lateralization in childhood

Minarose M. Ismail, Davide Momi, Zheng Wang, Sorenza P Bastiaens et autres

Hemispheric specialization is a hallmark of brain organization, yet how functionally specialized circuits develop remains unclear. In humans, the developmental shift toward left-hemisphere dominance for language offers a well-characterized model for investigating this question. Here, we built personalized whole-brain neurophysiological models in …

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Stereo‐ EEG mapping of visual working memory with task‐related high‐gamma modulations

Brian Ervin, Jason Buroker, Taylor B. Cummins, Anna W. Byars et autres

OBJECTIVE: We describe a safe, informative, and easy-to-implement approach for presurgical mapping of visual working memory (VWM) with stereo-electroencephalography (SEEG). METHODS: Twenty-four patients with drug-resistant epilepsy, 11-23 years of age, performed a single-probe change detection VWM task, during SEEG monitoring. High-gamma modulations …

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Localization and duration dependent effects of pediatric refractory epilepsy on language function

Brian Ervin, Yash Agarwal, Jason Buroker, Craig Scholle et autres

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Electrical stimulation for the induction of seizures is safe, well-tolerated and high-yield in children with drug-resistant epilepsy

Lucy Tarcha, Darcy A. Krueger, Hansel M. Greiner, Jesse M. Skoch et autres

INTRODUCTION: Drug-refractory epilepsy (DRE) affects one-third of children with epilepsy and can be treated with surgery. The surgical target is determined by recording spontaneous seizures during stereoelectroencephalography (sEEG). In adults, induced seizures help define the surgical target and predict favorable outcomes. No …

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Behavior‐ iEEG ‐Spectral‐Power‐Correlation: Defining Neural Substrates of Naturalistic Behavior

Brian Ervin, Clayton Frink, Jason Buroker, Paul S. Horn et autres

OBJECTIVE: Intracranial language localization with electrical stimulation mapping (ESM) and high-gamma modulation (HGM) mapping relies on artificial, repetitive tasks, requiring sustained cooperation from patients. Herein, we tested the validity of unstructured, interpersonal, naturalistic conversation for language localization, using a novel methodology: Behavior-iEEG-Spectral-Power …

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Electrical Stimulation for the Induction of Seizures is Safe, Well-tolerated and High-Yield in Children with Drug-Resistant Epilepsy

Lucy Tarcha, Darcy A. Krueger, Hansel M. Greiner, Jesse M. Skoch et autres

Introduction: One third of children with epilepsy develop drug-resistant epilepsy (DRE). Epilepsy surgery is the treatment for DRE, and selecting the surgical target typically requires recording spontaneous seizures during intracranial monitoring with stereoelectroencephalography (sEEG). In adults, induced seizures have been shown to …

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Intracranial High-Frequency Oscillations and Epileptogenic Zone: Incorporating Neuroanatomic Variation

Daniel R Wendelken, Brian Ervin, Jason Buroker, Craig Scholle et autres

PURPOSE: To determine if incorporating neuroanatomic or intersubject variation in the occurrence rate of intracranial high-frequency oscillations improves its diagnostic performance for localization of epileptogenic zone (EZ). METHODS: Five minutes of awake stereo-electroencephalography data from 59 patients were analyzed. High-frequency oscillations were …

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Responsive Neurostimulation of Thalamic and Nonthalamic Targets in Pediatric and Young Adult Patients With Intractable Epilepsy

Thomas Larrew, Hansel M. Greiner, Ravindra Arya, Jeffrey R. Tenney et autres

BACKGROUND AND OBJECTIVES: Epilepsy is a significant cause of morbidity and has negative effects on cognitive and psychosocial development in pediatric and young adult patients. For pediatric patients who have epileptogenic foci that are poorly localized, deep, bilateral, or in eloquent regions …

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Prognostic application of lesion network mapping to epilepsy surgery outcomes in pediatric tuberous sclerosis complex

Kara B. Miecznikowski, Hansel M. Greiner, James Leach, Leonid Rozhkov et autres

OBJECTIVE: Patients with tuberous sclerosis complex (TSC)-related epilepsy often have drug-refractory epilepsy and numerous potential epileptogenic tubers. Current clinical methods target tubers for resection, but prediction of resulting seizure relief is difficult. This study describes implementation of lesion network mapping in TSC …

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121. Treatment of Catamenial Epilepsy with Norethindrone Acetate: A Case Report

Hansel M. Greiner, Lesley L Breech

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Altered cortical excitability in tuberous sclerosis and the effect of mTOR inhibitors: An intracranial electrical stimulation study

Kishore Vedala, Gewalin Aungaroon, David M. Ritter, Hansel M. Greiner et autres

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