Robyn M. Sutherland

Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial

Lise J Estcourt, Zoe McQuilten, Peter Bardy, Merrole Cole‐Sinclair et autres

Cellular and Cell-Free Genomic Characterization of Patients Receiving Avatrombopag and Immunosuppressive Therapy for Treatment-Naïve Severe Aplastic Anemia

Lucy C. Fox, Sally M. Hunter, Stephen B. Ting, Lê Thị Phương Thảo et autres

Background The efficacy and safety of avatrombopag, a second generation thrombopoietin-receptor agonist, in the treatment of newly diagnosed severe aplastic anemia (sAA) is being evaluated in the DIAAMOND-Ava-FIRST trial. Herein, we report somatic and germline molecular findings of this study in which …

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Efficacy and Safety of Avatrombopag in Combination with Immunosuppressive Therapy in Treatment-Naïve Severe Aplastic Anemia: Results of the Diaamond-Ava-First Trial

Zoe McQuilten, Lucy C. Fox, Stéphane Héritier, Vanessa Fox et autres

Background The addition of the thrombopoietin-receptor agonist (TPO-RA) eltrombopag to immunosuppressive therapy (IST) has been shown to improve hematological responses in severe aplastic anemia (sAA) (Peffault de Lattour, NEJM, 2022). Avatrombopag is a second generation TPO-RA that has not been studied in …

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Honouring Stories of Struggle: Reassessing Australia’s Records of Disadvantage – Hearing the Voices of Those Who Struggle

Robyn M. Sutherland

When deciding what and how documentation should be made and kept about the experiences of welfare recipients, it is vital to ensure that recordkeeping strategies meet the needs, preferences and expectations of the recipients of those services. This article presents a transcription …

Tranexamic Acid to Prevent Bleeding in Patients with Hematologic Malignancies and Severe Thrombocytopenia (TREATT trial). a Randomized Placebo-Controlled Trial

Lise J Estcourt, Zoe McQuilten, Peter Bardy, Merrole Cole‐Sinclair et autres

Conclusions LJE & ZM and EMW & SJS contributed equally Patients undergoing treatment for hematologic malignancies continue to have a high burden of clinically significant bleeding (WHO grade 2 or above) despite receiving prophylactic platelet transfusions (43% in TOPPS trial, NEJM 2013). …

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The Australian Aplastic Anaemia and other Bone Marrow Failure Syndromes Registry

Lucy C. Fox, Zoe McQuilten, Frank Firkin, Vanessa Fox et autres

The bone marrow failure syndromes (BMFS) are a diverse group of acquired and inherited diseases which may manifest in cytopenias, haematological malignancy and/or syndromic multisystem disease. Patients with BMFS frequently experience poor outcomes, and improved treatment strategies are needed. Collation of clinical …

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CIS controls the functional polarization of GM-CSF-derived macrophages

Shengbo Zhang, Jai Rautela, Naiara G. Bediaga, Tatiana B. Kolesnik et autres

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CIS calibrates GM-CSF signalling strength to regulate macrophage polarization via a STAT5-IRF8 axis

Shengbo Zhang, Jai Rautela, Naiara G. Bediaga, Tatiana B. Kolesnik et autres

Abstract The cytokine granulocyte-macrophage-colony stimulating factor (GM-CSF) possesses the ability to differentiate macrophages (MØs) with opposing functions, namely proinflammatory M1-like and immunosuppressive M2-like. Despite the importance and opposing functional outcomes of these processes, the intrinsic mechanism that regulates the functional polarization of …

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BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia

Emma M. Carrington, Cynthia Louis, Tobias Kratina, Manuela S. HANCOCK et autres

Neutrophils help to clear pathogens and cellular debris, but can also cause collateral damage within inflamed tissues. Prolonged neutrophil residency within an inflammatory niche can exacerbate tissue pathology. Using both genetic and pharmacological approaches, we show that BCL-XL is required for the …

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Prevention of Islet Inflammatory Stress with JAK1/JAK2 Inhibitors

Eleanor G. R. Watson, Michaela Waibel, Prerak Trivedi, Evan G. Pappas et autres

Introduction There is an opportunity to repurpose therapeutics from other diseases to autoimmunity and transplantation, especially when there is evidence for overlapping mechanisms. Inflammation is one of the main causes of islet damage and loss during islet isolation and transplantation, and autoimmune …

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Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ

Robyn M. Sutherland, Sarah L. Londrigan, Jamie L. Brady, Emma M. Carrington et autres

T-cell responses are initiated upon cognate presentation by professional antigen presenting cells in lymphoid tissue. T cells then migrate to inflamed tissues, but further T-cell stimulation in these parenchymal target sites is not well understood. Here we show that T-cell expansion within …

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Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo

Emma M. Carrington, Yifan Zhan, Jamie L. Brady, Jian‐Guo Zhang et autres

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