Accès ouvert
2026
article
OpenAlex
Mattia De Francisci, Edoardo Faggionato, Chiara Dalla Man, John J. Lee et autres
Within the Alzheimer disease (AD) spectrum, metabolic alterations occur in addition to proteinopathies. While hypometabolism is frequently observed in the late symptomatic stages, characterizing the metabolic changes during early AD stages might aid in both understanding its pathophysiology and in patient selection …
it, us
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Accès ouvert
2026
article
OpenAlex
Edoardo Faggionato, Michele Schiavon, Laya Ekhlaspour, Ryan Kingman et autres
Background: Quantifying the effect of meal composition (MC) on postprandial glucose excursions would allow optimizing insulin therapy, accounting for fat and protein that can affect gastric retention (GR), glucose rate of appearance (R a ), and insulin sensitivity (S I ). Such …
it, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Edoardo Faggionato, Alessio Tonello, MARCELLO C. LAURENTI, Adrian Vella et autres
The model can be used to quantify hepatic glucagon and insulin sensitivity, accounting also for glucagon evanescence over time. The ability to quantify glucagon effects on postprandial glucose metabolism will further our understanding of its role in the onset and progression of …
it, us
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Accès ouvert
2025
article
OpenAlex
Francesca S. Boscolo, Edoardo Faggionato, Andrew A. Welch, RAHELE A. FARAHANI et autres
In this study, we propose a new mathematical model able to quantify C-peptide secretion and β-cell responsivity in response to a glucagon bolus in individuals without and with type 2 diabetes. We show that individuals with type 2 diabetes exhibit reduced β-cell …
it, us
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Accès ouvert
2025
article
OpenAlex
Edoardo Faggionato, Michele Schiavon, Chiara Dalla Man
Meals with a high content of fat (F) and protein (P) still represent a significant challenge for optimal glycemic control in individuals with type 1 diabetes (T1D). Current strategies dealing with such meals require patients to undergo a series of trial-and-error visits …
it
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Accès ouvert
2023
article
OpenAlex
Edoardo Faggionato, Michele Schiavon, Laya Ekhlaspour, Bruce A. Buckingham et autres
OBJECTIVE: Modeling the effect of meal composition on glucose excursion would help in designing decision support systems (DSS) for type 1 diabetes (T1D) management. In fact, macronutrients differently affect post-prandial gastric retention (GR), rate of appearance (R[Formula: see text]), and insulin sensitivity …
it, us, au
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Accès ouvert
2023
article
OpenAlex
Edoardo Faggionato, MARCELLO C. LAURENTI, Adrian Vella, Chiara Dalla Man
Objective: To date, the lack of a model of glucagon kinetics precluded the possibility of estimating and studying glucagon secretionin vivo, e.g., using deconvolution, as done for other hormones like insulin and C-peptide. Here, we used a nonlinear mixed effects technique to …
it, us, lu
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Accès ouvert
2023
article
OpenAlex
Edoardo Faggionato, Alessandro Guazzo, Elena Pegolo, Ruggero Carli et autres
OBJECTIVE: Effective dosing of anticoagulants aims to prevent blood clot formation while avoiding hemorrhages. This complex task is challenged by several disturbing factors and drug-effect uncertainties, requesting frequent monitoring and adjustment. Biovariability in drug absorption and action further complicates titration and calls …
it
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2021
conference-paper
OpenAlex
Edoardo Faggionato, Michele Schiavon, Chiara Dalla Man
Subcutaneous insulin absorption is well-known to vary significantly both between and within subjects (BSV and WSV, respectively). This variability considerably obstacles the establishing of a reproducible and effective insulin therapy. Some models exist to describe the subcutaneous kinetics of both fast and …
it
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Accès ouvert
2021
article
OpenAlex
Edoardo Faggionato, Michele Schiavon, Chiara Dalla Man
Despite the great progress made in insulin preparation and titration, many patients with diabetes are still experiencing dangerous fluctuations in their blood glucose levels. This is mainly due to the large between- and within-subject variability, which considerably hampers insulin therapy, leading to …
it
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