Oxana Schmidt

Correction to: Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis

Oxana Schmidt, Nadja Nehls, Carolin Prexler, Kristina von Heyking et autres

An amendment to this paper has been published and can be accessed via the original article.

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Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis

Oxana Schmidt, Nadja Nehls, Carolin Prexler, Kristina von Heyking et autres

BACKGROUND: Histone acetylation and deacetylation seem processes involved in the pathogenesis of Ewing sarcoma (EwS). Here histone deacetylases (HDAC) class I were investigated. METHODS: Their role was determined using different inhibitors including TSA, Romidepsin, Entinostat and PCI-34051 as well as CRISPR/Cas9 class …

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Class I Histone Deacetylases (HDAC) Critically Contribute to Ewing Sarcoma Pathogenesis

Oxana Schmidt, Nadja Nehls, Carolin Prexler, Kristina von Heyking et autres

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Additional file 3 of Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis

Oxana Schmidt, Nadja Nehls, Carolin Prexler, Kristina von Heyking et autres

Additional file 3: Fig. S9. Whole Western blots with molecular weight markers in selected figures.

Additional file 2 of Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis

Oxana Schmidt, Nadja Nehls, Carolin Prexler, Kristina von Heyking et autres

Additional file 2: Fig. S1 a, Expression levels of different class I HDAC genes in different pediatric small-round-blue-cell tumors, carcinomas and normal tissues by box plot presentation using a comparative study of the amc onco-genomics software tool ( https://hgserver1.amc.nl/cgi-bin/r2/main.cgi ). The number …

Combined Inhibition of Epigenetic Readers and Transcription Initiation Targets the EWS-ETS Transcriptional Program in Ewing Sarcoma

Günther H.S. Richter, Tim Hensel, Oxana Schmidt, Vadim Saratov et autres

BACKGROUND: Previously, we used inhibitors blocking BET bromodomain binding proteins (BRDs) in Ewing sarcoma (EwS) and observed that long term treatment resulted in the development of resistance. Here, we analyze the possible interaction of BRD4 with cyclin-dependent kinase (CDK) 9. METHODS: Co-immunoprecipitation …

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Abstract A09: GPR64-specific CAR-transgenic T cells selectively kill Ewing sarcoma in vivo

David Schirmer, Isabel Storz, Karin Wisskirchen, Regina Feederle et autres

Abstract Introduction: Pediatric cancers, including Ewing sarcoma (EwS), are only weakly immunogenic and the tumor patient’s immune system often is devoid of effector T cells for tumor elimination. Based on expression profiling technology, targetable tumor-associated antigens (TAA) are identified and exploited for …

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Abstract PR13: Targeting p-TEFb as well as the EWS-ETS-specific transcriptional program in Ewing sarcoma synergistically blocks tumor growth

Tim Hensel, Chiara Giorgi, Oxana Schmidt, Hsi-Yu Yen et autres

Abstract Introduction: Ewing sarcomas (EwS) are highly malignant bone or soft tissue tumors. Genetically, EwS are defined by balanced chromosomal EWSR1/ETS translocations, which give rise to chimeric proteins (EWSR1-ETS) that generate an oncogenic transcriptional program associated with altered epigenetic marks throughout the …

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Matrix mineralization controls gene expression in osteoblastic cells

Johannes Wischmann, Florian Walter Lenze, Antonia Thiel, Sakina Bookbinder et autres

Osteoblasts are adherent cells, and under physiological conditions they attach to both mineralized and non-mineralized osseous surfaces. However, how exactly osteoblasts respond to these different osseous surfaces is largely unknown. Our hypothesis was that the state of matrix mineralization provides a functional …

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Abstract 3181: Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis

Oxana Schmidt, Nadja Nehls, Kristina von Heyking, Tim Hensel et autres

Abstract Introduction: Recent evidence demonstrated that a low mutation rate seems a general feature of pediatric cancers. Ewing sarcoma (EwS) is defined by balanced chromosomal EWS/ETS translocations, which give rise to oncogenic chimeric proteins (EWS-ETS). Previously, we identified the histone methyl-transferase enhancer …

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Abstract B38: Ewing sarcoma regression without GVHD by allo-MHC/CHM1 specific T cells

Uwe Thiel, Sebastian Johannes Schober, Ingo Einspieler, A. Kirschner et autres

Abstract Background: Chondromodulin-I (CHM1) sustains malignancy in Ewing sarcoma (ES). Refractory ES carries a dismal prognosis and patients with bone-marrow (BM) metastases do not survive irrespective of therapy. We assessed HLA-A*02:01/CHM1 specific allorestricted T-cell receptor (TCR) wild-type and transgenic cytotoxic (CD8+) T …

Abstract B02: Combined targeting of the Ewing sarcoma transcriptional program by blocking epigenetic readers and transcription initiation via EWS-FLI1

Tim Hensel, Chiara Giorgi, Fiona AG Becker-Dettling, Julia Calzada‐Wack et autres

Abstract Introduction: We reported blocking of BET bromodomain binding proteins (BRDs) by use of an inhibitor (JQ1) and the associated strong downregulation of the predominant EWS-ETS protein EWS-FLI1 in Ewing sarcoma (ES). Here we analyzed in depth the mechanistic effects of this …

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