Alana McGovern

Sampling distributions for complex design variance estimators in a Fay-Herriot model

Alana McGovern, Geir‐Arne Fuglstad, Jon Wakefield

Fay-Herriot (FH) models with variance smoothing typically use chi-squared sampling distributions for the design variance estimators. This choice is only valid under strong assumptions on the population and the sampling design, and the choice of sampling distribution is understudied for complex survey …

Sampling distributions for complex design variance estimators in a Fay-Herriot model

Alana McGovern, Geir‐Arne Fuglstad, Jon Wakefield

Fay-Herriot (FH) models with variance smoothing typically use chi-squared sampling distributions for the design variance estimators. This choice is only valid under strong assumptions on the population and the sampling design, and the choice of sampling distribution is understudied for complex survey …

us, ru (code pays fourni par la source)

Bayesian Small Area Estimation Methods for Sparse Complex Survey Data

Alana McGovern

Thesis (Ph.D.)--University of Washington, 2026

us (code pays fourni par la source)

Direct-assisted Bayesian Unit-Level Modeling for Small Area Estimation of Rare Event Prevalence

Alana McGovern, Katherine A. Wilson, Jon Wakefield

Abstract Small-area estimation using survey data can be achieved by using either a design-based or a model-based inferential approach. Design-based direct estimators are generally preferable because of their consistency, asymptotic normality, and reliance on fewer assumptions. However, when data are sparse at …

us (code pays fourni par la source)

Direct-Assisted Bayesian Unit-level Modeling for Small Area Estimation of Rare Event Prevalence

Alana McGovern, Katherine Wilson, Jon Wakefield

Small area estimation using survey data can be achieved by using either a design-based or a model-based inferential approach. Design-based direct estimators are generally preferable because of their consistency, asymptotic normality, and reliance on fewer assumptions. However, when data are sparse at …

A comparative analysis of IDH-mutant glioma in pediatric, young adult, and older adult patients

Mary Jane Lim-Fat, Jennifer Cotter, Mehdi Touat, Jayne Vogelzang et autres

BACKGROUND: The frequency and significance of IDH mutations in glioma across age groups are incompletely understood. We performed a multi-center retrospective age-stratified comparison of patients with IDH-mutant gliomas to identify age-specific differences in clinico-genomic features, treatments, and outcomes. METHODS: Clinical, histologic, and …

ca, us, fr (code pays fourni par la source)

Two‐stage subgroup‐specific time‐to‐event (2S‐Sub‐TITE): An adaptive two‐stage time‐to‐toxicity design for subgroup‐specific dose finding in phase I oncology trials

Alana McGovern, Andrew Chapple, Clement Ma

For phase I trials, the subgroup-specific time-to-event (Sub-TITE) design identifies the maximum tolerated dose (MTD) separately in 2+ heterogeneous patient subgroups. Sub-TITE allows borrowing strength and dynamic clustering across subgroups from the trial's start, but delaying the initiation of borrowing and clustering …

us, ca (code pays fourni par la source)

Early parental knowledge of late effect risks in children with cancer

Kendall Carpenter, Madison Scavotto, Alana McGovern, Clement Ma et autres

BACKGROUND/OBJECTIVES: Despite the pervasiveness of late effects in childhood cancer survivors, many parents feel inadequately informed about their child's risks. We assessed early parental knowledge of risks of late effects and predictors of increased knowledge. DESIGN/METHODS: Parents of children receiving cancer treatment …

us, ca (code pays fourni par la source)

Race, ethnicity, and goal‐concordance of end‐of‐life palliative care in pediatric oncology

Puja J. Umaretiya, Anran Li, Alana McGovern, Clement Ma et autres

BACKGROUND: Racial and ethnic minority children with cancer disproportionately receive intensive care at the end of life (EOL). It is not known whether these differences are goal-concordant or disparities. The authors sought to explore patterns of pediatric palliative care (PPC) and health …

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EPID-11. A MULTI-INSTITUTIONAL COMPARATIVE ANALYSIS OF THE CLINICAL, GENOMIC, AND SURVIVAL CHARACTERISTICS OF PEDIATRIC, YOUNG ADULT AND OLDER ADULT PATIENTS WITH IDH-MUTANT GLIOMA

Mary Jane Lim-Fat, Jayne Vogelzang, E. L. Woodward, Alana McGovern et autres

Abstract BACKGROUND Prognostic significance of IDH-mutation in glioma is incompletely understood in children and adolescents/young adults (YAs). We compared the clinico-genomic features, outcomes and prognostic factors observed in IDH-mutant gliomas across age groups. METHODS Clinical, histologic and molecular data of patients with …

us, fr (code pays fourni par la source)