Ryota Nakano

Aberrant alternative splicing memorized in adipose tissue macrophages impedes efferocytosis during postobesity weight loss

Takuro Miyazaki, Akira Shiraishi, Yuki Sugiura, Eisuke Shiozawa et autres

Obesity imprints an epigenetic memory in adipose tissue macrophages (ATMs), allowing proinflammatory traits to persist after weight loss. However, mechanisms by which ATMs sustain efferocytosis and influence adipose tissue mass remain unclear. Here, we demonstrate that aberrant messenger RNA splicing, caused by …

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Royal jelly ameliorates anxiety- and depression-like behaviors in ovariectomized mice via modulation of serotonergic and inflammatory pathways

Momoko Takenaka, Ryota Nakano, Yoshitaka Yamazaki, Yuki Uchida et autres

Anxiety and depressive symptoms in postmenopausal women represent a significant health concern. Royal jelly (RJ), a natural product with anti-inflammatory, antioxidant, and estrogen-like activities, has emerged as a promising candidate for the management of postmenopausal symptoms; however, its effects on psychological symptoms …

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Intermittent Hypoxia Induces Cognitive Dysfunction and Hippocampal Gene Expression Changes in a Mouse Model of Obstructive Sleep Apnea

Kenta Miyo, Yuki Uchida, Ryota Nakano, Shotaro Kamijo et autres

Obstructive sleep apnea syndrome (OSAS) is characterized by cycles of decreased blood oxygen saturation followed by reoxygenation due to transient apnea. Cognitive dysfunction is a complication of OSAS, but its mechanisms remain unclear. Eight-week-old C57BL/6J mice were exposed to intermittent hypoxia (IH) …

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Change in pulse wave transit time measured using ear plethysmography is a useful substitute for finger plethysmography

Ryota Nakano, Midoriko Higashi, Kazuhiro Shirozu, Makoto Sumie et autres

PURPOSE: Plethysmography using the finger is affected by various clinical conditions, including sympathetic tone. This study aimed to evaluate whether pulse wave transit time (PWTT) calculated using ear plethysmography could be used as a substitute for finger PWTT. METHODS: In this prospective …

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Intermittent Hypoxia Induces Cognitive Dysfunction and Hippocampal Gene Expression Changes in a Mouse Model of Obstructive Sleep Apnea

Kenta Miyo, Yuki Uchida, Ryota Nakano, Shotaro Kamijo et autres

Obstructive sleep apnea syndrome (OSAS) is characterized by cycles of decreased blood oxygen saturation followed by reoxygenation due to transient apnea. Cognitive dysfunction is a complication of OSAS, but its mechanisms remain unclear. 8-week-old C57BL/6J mice were exposed to intermittent hypoxia (IH) …

jp (code pays fourni par la source)

Sa1417: VARIATIONS IN SUPPORTIVE TREATMENT STRATEGIES DURING ENDOSCOPIC MANAGEMENT OF PANCREATIC FLUID COLLECTIONS: NATIONWIDE QUESTIONNAIRE SURVEY BY THE WONDERFUL STUDY GROUP IN JAPAN

Nobuhiko Hayashi, Tsuyoshi Hamada, Takuji Iwashita, Mamoru Takenaka et autres

Paternal exposure to methylphenidate causes behavioral abnormalities in grandchildren

Ryota Nakano, Riko Ikeda, Yoshitaka Yamazaki, Sakiko Munetomo-Aoki et autres

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is widely observed from childhood to adulthood and is treated with methylphenidate (MPH) as a first-line treatment. However, recent findings indicate that the paternal environment preceding conception may influence offspring health, potentially affecting subsequent …

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Oral administration of Bifidobacterium longum and Bifidobacterium infantis ameliorates cefcapene pivoxil-induced attenuation of anti-programmed cell death protein-1 antibody action in mice

Eiji Funayama, Masahiro Hosonuma, Kohei Tajima, Junya Isobe et autres

Gut bacteria play pivotal roles in the antitumor effects of immune checkpoint inhibitors (ICIs). However, antimicrobial therapy, often necessary for infections in cancer patients, can reduce the efficacy of ICIs. The potential of probiotics to restore ICI efficacy remains uncertain. This study …

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PRACTICAL TECHNIQUES FOR LUMEN-APPOSING METAL STENT PLACEMENT IN WALLED-OFF NECROSIS: WONDERFUL STUDY GROUP

Sho Adnas Takahashi, Tomotaka Saito, Toshio Fujisawa, Shunsuke Omoto et autres

ASSOCIATION OF DEEP LEARNING-BASED SKELETAL MUSCLE MEASUREMENTS WITH CLINICAL OUTCOMES IN ENDOSCOPIC TREATMENT OF PANCREATIC FLUID COLLECTION: THE WONDERFUL STUDY

Mamoru Takenaka, Tsuyoshi Hamada, Wataru Gonoi, Shouhei Hanaoka et autres

Paternal methamphetamine exposure differentially affects first and second generations in mice

Sakiko Munetomo-Aoki, Asuka Kaizaki‐Mitsumoto, Ryota Nakano, Satoshi Numazawa

Amphetamine-type stimulants are abused worldwide, and methamphetamine (METH) accounts for a large majority of seized abused drug cases. Recently, the paternal origin of health and disease theory has been proposed as a concept wherein paternal factors influence descendants. Although METH abuse is …

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Alteration of gene levels in fetal brain by prenatal exposure to methylmercury, copper, and their combination

Kensuke Satô, Ryota Nakano, Yoshitaka Yamazaki, Hikaru Isobe et autres

Methylmercury (MeHg), a potent neurotoxin, poses substantial risks to prenatal brain development by crossing the placental barrier. In our daily lives, we are exposed to various environmental metals simultaneously with MeHg. Therefore, the combined exposure effects of these metals and MeHg should …

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