Jianzhou Zou

Association between systemic immune-inflammation index and mortality in patients receiving maintenance hemodialysis: a retrospective cohort study

Yaqiong Wang, Jinbo Yu, Fangfang Xiang, Xuesen Cao et autres

Chronic inflammation is common in patients receiving maintenance hemodialysis (MHD) and is closely related to adverse clinical outcomes. The clinical significance of the systemic immune-inflammation index (SII), a composite marker derived from routine blood cell counts, has not been fully characterized in …

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Indoxyl sulfate exacerbates chronic inflammation and susceptibility to severe infection via modulating T-cell CD73/adenosine signaling in chronic kidney disease

Jilai Cao, Yuxin Nie, Xuesen Cao, Xiaohong Chen et autres

BACKGROUND: Chronic kidney disease (CKD) is a major global health issue. Cardiovascular events and infections drive mortality in end-stage renal disease via immune dysregulation. The role of T-cell purinergic signaling and its modulation by indoxyl sulfate (IS) in CKD remains unclear. METHODS: …

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Altered CD73-Adenosine Signaling Linked to Infection in Patients undergoing hemodialysis

Fangfang Xiang, Zhen Zhang, Yuxin Nie, Xuesen Cao et autres

Purpose: Infection is the most common cause of hospitalization and the second most common cause of mortality among patients undergoing hemodialysis (HD). The enzyme CD73, a cell surface 5′-nucleotidase, regulates the balance between pro-inflammatory nucleotides and anti-inflammatory adenosine. Diminished CD73-adenosine signaling contributes …

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Early goal-directed renal replacement therapy in severe pneumonia associated acute kidney injury

Abuduxiukuer Yusufu, Yeqing Xie, Yanting Shi, Wuhua Jiang et autres

Introduction Severe pneumonia is a crucial issue in the development of acute kidney injury (AKI). This study evaluated the efficacy of early goal-directed renal replacement therapy (GDRRT) for the treatment of severe pneumonia-associated AKI.Methods In this real-world retrospective cohort study, we recruited …

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CD73 as a T cell dysfunction marker predicting cardiovascular and infection events in patients undergoing hemodialysis

Fangfang Xiang, Lin Sun, Xuesen Cao, Yang Li et autres

T cell dysfunction observed in patients undergoing hemodialysis (HD) has been linked to an extremely high morbidity of cardiovascular events (CVEs) and infections. The cell-surface 5′-nucleotidase CD73 sets the balance between pro-inflammatory nucleotides and anti-inflammatory adenosine. A total of 395 patients who …

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Metagenome-wide analysis uncovers gut microbial signatures and implicates taxon-specific functions in end-stage renal disease

Pan Zhang, Xifan Wang, Shenghui Li, Xuesen Cao et autres

BACKGROUND: The gut microbiota plays a crucial role in regulating host metabolism and producing uremic toxins in patients with end-stage renal disease (ESRD). Our objective is to advance toward a holistic understanding of the gut ecosystem and its functional capacity in such …

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Immunological features of ESRD patients undergoing hemodialysis of various ages

Fangfang Xiang, Xuesen Cao, WenLv Lv, Bo Shen et autres

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A NOVEL RAT MODEL OF CONTRAST-INDUCED ACUTE KIDNEY INJURY BASED ON RENAL CONGESTION AND THE RENO-PROTECTION OF MITOCHONDRIAL FISSION INHIBITION

Qiang Yang, Jiachang Hu, Yichun Ning, Shuan Zhao et autres

ABSTRACT: Contrast-induced acute kidney injury (CI-AKI) is a serious and common complication in patients receiving intravenous iodinated contrast medium (CM). Clinically, congestive heart failure is the most critical risk factor for CI-AKI and always leads to renal congestion for increased central venous …

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Predictive role of cardiac valvular calcification in all-cause mortality of Chinese initial haemodialysis patients: a follow-up study of 4 years

Yun Cheng, Zhihui Lu, Xuesen Cao, Xiaoqiang Ding et autres

BACKGROUND: Cardiac valvular calcification (CVC) is prevalent in haemodialysis (HD) patients. Its association with mortality in Chinese incident haemodialysis (IHD) patients remains unknown. METHODS: A total of 224 IHD patients who had just begun HD therapy at Zhongshan Hospital, Fudan University, were …

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Effects of p-cresol, a uremic toxin, on cancer cells

Fangfang Xiang, Xuesen Cao, Jianzhou Zou, Boheng Zhang et autres

Background: Though p-cresol exists at a low concentration in the blood, it accumulates in various organs of uremic patients. Previous research has shown that the p-cresol promoted bladder cancer cell invasion and migration. This study aims to see if p-cresol had similar …

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Additional file 1 of Metagenome-wide analysis uncovers gut microbial signatures and implicates taxon-specific functions in end-stage renal disease

Pan Zhang, Xifan Wang, Shenghui Li, Xuesen Cao et autres

Additional file 1: Table S1. Summary on statistics of the host properties and clinical parameters from the Shanghai and Beijing cohorts. Table S2. Summary of deep whole-metagenomic shotgun sequencing data production of this study. Table S3. Detailed information of data production, assembly, …

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Altered gut microbiota and gut-derived p-cresyl sulfate serum levels in peritoneal dialysis patients

Manchen Bao, Pan Zhang, Shulan Guo, Jianzhou Zou et autres

Peritoneal dialysis (PD) is a renal replacement therapy for end-stage renal disease. Gut microbiota-derived uremic solutes, indoxyl sulfate (IS), p-cresyl sulfate (PCS), and trimethylamine-N-oxide (TMAO) accumulate in PD patients. The objective was to explore the gut microbiota and their influence on uremic …

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