Hironobu Koga

257P Prognostic impact of N1 micrometastasis in pT1–2a non-small cell lung cancer: An IPTW-adjusted cohort study

Hironobu Koga, T. Woo, K. Okudera, K. Watanabe et autres

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171P: Prognostic impact of lymph node micrometastasis in T1-2a non-small cell lung cancer

Hironobu Koga, Tina M. Woo, Akiko M. Saito, Koichi Okudera et autres

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A high α1-antitrypsin/interleukin-10 ratio predicts bacterial pneumonia in adults with community-acquired pneumonia: a prospective cohort study

Taiga Miyazaki, Kiyoyasu Fukushima, Kohji Hashiguchi, Shotaro Ide et autres

BACKGROUND: Current microbiological tests fail to identify the causative microorganism in more than half of all pneumonia cases. We explored biomarkers that could be used for differentiating between bacterial and viral pneumonia in patients with community-acquired pneumonia (CAP). METHODS: In this prospective …

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Effect of long‐term clarithromycin therapy on prevention of pneumonia in older adults: A randomized, controlled trial

Mari Yamasue, Kosaku Komiya, Hiroki Yoshikawa, Yoshihisa Kohno et autres

AIM: Pneumonia in older adults is increasingly recognized as a healthcare issue in countries with an aging population. Long-term macrolide therapy reduces exacerbations of chronic respiratory diseases, but its effects on the prevention of pneumonia have not been determined. METHODS: We carried …

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The efficacy and safety of sitafloxacin and garenoxacin for the treatment of pneumonia in elderly patients: A randomized, multicenter, open-label trial

Taiga Miyazaki, Shigeki Nakamura, Kohji Hashiguchi, Tsutomu Kobayashi et autres

Oral treatment for elderly outpatients with pneumonia is becoming increasingly important in this super-aged society from the perspective of cost-effectiveness and limited hospital capacities. We evaluated the efficacy and safety of two oral respiratory quinolones, sitafloxacin and garenoxacin, in elderly patients with …

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Exhaustive SAR analysis tools for HTS hits based on intuition of medicinal chemists

Hironobu Koga

High-throughput screening (HTS) is a common practice in drug discovery.Although the chemoinformatics community has proposed various approaches for HTS data analysis, medicinal chemists continue to long for intuitive tools for the structure-activity relationship (SAR) analysis of HTS hits.Here, the author propose SAR …

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Radon Therapy for Autoimmune Diseases Pemphigus and Diabetes: 2 Case Reports

Shuji Kojima, Jerry M. Cuttler, Noriko Shimura, Hironobu Koga et autres

We report on the application of radon therapy to relieve the suffering of 2 patients with autoimmune diseases, one with pemphigus with an old myocardial infarction and diabetes mellitus and the other with type I diabetes. We include a lengthy discussion of …

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Radon Therapy Is Very Promising as a Primary or an Adjuvant Treatment for Different Types of Cancers: 4 Case Reports

Shuji Kojima, Jerry M. Cuttler, Kiyomi Inoguchi, Kenshou Yorozu et autres

We report on the application of radon inhalation therapy to patients with 4 types of cancer: colon, uterine, lung, and liver cell. The radon treatments were given to improve the efficacy of chemotherapy and were potent in all 4 cases. Marker values …

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Recovery From Rheumatoid Arthritis Following 15 Months of Therapy With Low Doses of Ionizing Radiation: A Case Report

Shuji Kojima, Mitsutoshi Thukimoto, Jerry M. Cuttler, Kiyomi Inoguchi et autres

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that occurs commonly in old people. Hot spring radon therapy is widely practiced in Central Europe and Japan for relief from the painful symptoms. The usual duration of a spa treatment is a week …

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Present and Future Prospects of Radiation Therapy Using α-Emitting Nuclides

Shuji Kojima, Jerry M. Cuttler, Noriko Shimura, Hironobu Koga et autres

Therapy with α-radiation has issues associated with internal exposure; its clinical use has been avoided. However, phase III clinical tests of the α-emitting nuclide 223 Ra on patients with cancer have been conducted, and results were reported in 2011 to 2012. Since …

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Treatment of Cancer and Inflammation With Low-Dose Ionizing Radiation

Shuji Kojima, Mitsutoshi Tsukimoto, Noriko Shimura, Hironobu Koga et autres

There is considerable evidence from experimental studies in animals, as well as from clinical reports, that low-dose radiation hormesis is effective for the treatment of cancer and ulcerative colitis. In this study, we present 3 case reports that support the clinical efficacy …

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Combination Therapy with Fluconazole and Flucytosine for Pulmonary Cryptococcosis

Yoshihiro Yamamoto, Shigefumi Maesaki, Hiroshi Kakeya, Katsunori Yanagihara et autres

We investigated, in vitro, the combined effects of fluconazole (FLCZ) and flucytosine (5-FC) against different strains of Cryptococcus neoformans, and retrospectively analyzed the clinical efficacy of combination therapy of FLCZ and 5-FC in patients with pulmonary cryptococcosis. The minimum inhibitory concentrations (MICs) …

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