Kohei Yagi

Myocardial ischemia risk in Fontan candidates with pulmonary atresia with intact ventricular septum

Naoki Masaki, Hideki Tatewaki, Satoshi Matsuo, Masaru Kumae et autres

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Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular HCC

Tomohiko Taniai, Shu Shimada, Yoshimitsu Akiyama, Megumi Hatano et autres

BACKGROUND AND AIMS: Recent advances in single-cell RNA sequencing (scRNA-seq) technologies have enabled us to clarify gene regulatory networks and immune cell compositions. In this study, the integration of large-scale bulk and single-cell datasets refined HCC classification and shed light on the …

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Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease–related HCC

Megumi Hatano, Yoshimitsu Akiyama, Shu Shimada, Kohei Yagi et autres

BACKGROUND: NAFLD caused by abnormalities in hepatic lipid metabolism is associated with an increased risk of developing HCC. The molecular mechanisms underlying the progression of NAFLD-related HCC are not fully understood. We investigated the molecular mechanism and role of KDM6B downregulation in …

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Loss of SFXN1 mitigates lipotoxicity and predicts poor outcome in non-viral hepatocellular carcinoma

Kohei Yagi, Shu Shimada, Yoshimitsu Akiyama, Megumi Hatano et autres

Hepatocellular carcinoma (HCC) imposes a huge global burden, arising from various etiological factors such as hepatitis virus infection and metabolic syndrome. While prophylactic vaccination and antiviral treatment have decreased the incidence of viral HCC, the growing prevalence of metabolic syndrome has led …

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MGMT is frequently inactivated in pancreatic NET-G2 and is associated with the therapeutic activity of STZ-based regimens

Kohei Yagi, Hiroaki Ono, Atsushi Kudo, Yuko Kinowaki et autres

O6-methylguanine-DNA methyltransferase (MGMT) has been linked with alkylating agent resistance and tumor growth suppression. However, its role remains undetermined in pancreatic neuroendocrine tumors (Pan-NET). The MGMT expression was examined by immunohistochemistry in 142 patients to evaluate MGMT immunoreactivity and clinicopathological factors. We …

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Inactivation of MGMT is Associated With the Efficacy of Streptozocin and High-grade Pancreatic Neuroendocrine Neoplasms

Kohei Yagi, Hiroaki Ono, Atsushi Kudo, Yuko Kinowaki et autres

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Inactivation of MGMT is Associated With the Efficacy of Streptozocin and High-grade Pancreatic Neuroendocrine Neoplasms

Kohei Yagi, Hiroaki Ono, Atsushi Kudo, Yuko Kinowaki et autres

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The extended bundle of the tensor veli palatini: Anatomic consideration of the dilating mechanism of the Eustachian tube

Ryuhei Okada, Satoru Muro, Kohtaro Eguchi, Kohei Yagi et autres

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