Jessica M. Fogel

Improving HIV Prevention Among Heterosexual Men Seeking Sexually Transmitted Infection Services in Malawi: Protocol for a Type I Effectiveness-Implementation Hybrid Randomized Controlled Trial of Systems Navigator-Delivered Integrated Prevention Package (HPTN 112-NJIRA Study).

Erica L Hamilton, Julie Pulerwitz, Mathews Mukatipa, Dan Haines et autres

BACKGROUND: Preexposure prophylaxis (PrEP) remains one of the most efficacious interventions for preventing HIV, but its effectiveness is often limited by poor persistence. Although regional efforts have primarily focused on young women and men who have sex with men, heterosexual men in …

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Prospective HIV RNA Screening With Long-acting Cabotegravir Pre-exposure Prophylaxis in HPTN 083

Raphael J. Landovitz, Jessica M. Fogel, Fei Gao, Brett S. Hanscom et autres

BACKGROUND: Pre-exposure prophylaxis (PrEP) is highly effective for HIV prevention. However, breakthrough infections can occur, even with optimal adherence. We evaluated the performance of prospective HIV RNA screening in cisgender men and transgender women who have sex with men using long-acting injectable …

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Prevalence of Illicit Drug Detection in 5 US Cities Among Out-of-Treatment People Who Inject Drugs

Nabila El-Bassel, STEVEN J. SHOPTAW, Timothy Skalland, Brett S. Hanscom et autres

Importance: In the US, the overdose crisis continues to be driven by fentanyl, xylazine, and stimulant-involved polysubstance use among people who inject drugs, especially those who are not engaged in medical care. Objective: To estimate the overall prevalence of illicit drugs detected …

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Sustained HIV Suppression With Co-formulated Tenofovir Disoproxil Fumarate/Lamivudine/Dolutegravir in a Person With Transmitted Dolutegravir Resistance and Pretreatment Resistance to Lamivudine: a Case Report From HPTN 083

Hannah P. Moore, Jessica M. Fogel, Mark A. Marzinke, Elias Konstantine Halvas et autres

Integrase strand transfer inhibitors (INSTIs) are recommended in most first-line HIV treatment regimens. We describe a participant in a clinical trial with transmitted INSTI resistance. The participant had no history of INSTI use and had no evidence of INSTI exposure prior to …

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Improving HIV Prevention Among Heterosexual Men Seeking Sexually Transmitted Infection Services in Malawi: Protocol for a Type I Effectiveness-Implementation Hybrid Randomized Controlled Trial of Systems Navigator–Delivered Integrated Prevention Package (HPTN 112-NJIRA Study)

Sarah E. Rutstein, Laura Limarzi-Klyn, Jane S. Chen, Yaw O Agyei et autres

BACKGROUND: Preexposure prophylaxis (PrEP) remains one of the most efficacious interventions for preventing HIV, but its effectiveness is often limited by poor persistence. Although regional efforts have primarily focused on young women and men who have sex with men, heterosexual men in …

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Use of DNA profiling to resolve HIV status in a person using injectable cabotegravir for HIV pre-exposure prophylaxis

Jessica M. Fogel, Mahdi Salih, Kathy Haddaway, Mark A. Marzinke et autres

HIV diagnosis can be especially challenging in persons using long-acting cabotegravir (CAB-LA) pre-exposure prophylaxis (PrEP) due to long-acting early viral inhibition (LEVI).1 New infections are usually clinically silent in this setting and are often missed using routine screening assays due to prolonged …

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Gaps in HIV Treatment and Care Cascade Among Men and Transfeminine Persons Who Have Sex with Men in Kenya, Malawi, and South Africa: Findings from the HIV Prevention Trials Network 075 Study (2015–2017)

Theo G. M. Sandfort, Daniel W. Szydlo, Jessica M. Fogel, Yamikani Chimwaza et autres

Improving HIV outcomes for men who have sex with men (MSM) in sub-Saharan Africa requires addressing gaps in the HIV treatment cascade. This study examined these gaps among 71 treatment-naive MSM with HIV in the HIV Prevention Trials Network 075, a 1-year …

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Improving HIV Prevention Among Heterosexual Men Seeking Sexually Transmitted Infection Services in Malawi: Protocol for a Type I Effectiveness-Implementation Hybrid Randomized Controlled Trial of Systems Navigator–Delivered Integrated Prevention Package (HPTN 112-NJIRA Study) (Preprint)

Sarah E. Rutstein, Laura Limarzi-Klyn, Jane S. Chen, Yaw O Agyei et autres

BACKGROUND Preexposure prophylaxis (PrEP) remains one of the most efficacious interventions for preventing HIV, but its effectiveness is often limited by poor persistence. Although regional efforts have primarily focused on young women and men who have sex with men, heterosexual men in …

Features of HIV Infection in the Context of Long-Acting Cabotegravir Preexposure Prophylaxis

Deborah J Donnell, Paul A. Richardson, Alex R. Rinehart, Adeola Adeyeye et autres

To the Editor: The results of the HIV Prevention Trials Network (HPTN) 083 and 084 trials (ClinicalTrials.gov numbers, NCT02720094 and NCT03164564, respectively) showed that longacting injectable cabotegravir (CAB-LA) was superior to daily oral tenofovir disoproxil fumarate–emtricitabine in the prevention of sexual transmission …

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Features of HIV Infection in the Context of Long-Acting Cabotegravir Preexposure Prophylaxis

Raphael J. Landovitz, Sinéad Delany‐Moretlwe, Jessica M. Fogel, Mark A. Marzinke et autres

Preexposure prophylaxis is emerging as an important tool to prevent HIV-1 infection. This report describes an altered presentation of acute HIV infection that may occur with use of long-acting cabotegravir PrEP.

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Evaluation of Xpert point-of-care assays for detection of HIV infection in persons using long-acting cabotegravir for pre-exposure prophylaxis

Jessica M. Fogel, Estelle Piwowar-Manning, Amber Moser, Tinia Hill et autres

Detection of HIV infection may be challenging in persons using long-acting cabotegravir (CAB-LA) pre-exposure prophylaxis (PrEP) due to viral suppression and reduced/delayed antibody production. We evaluated two point-of-care tests for detecting HIV infection in persons who received CAB-LA in the HPTN 083 …

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Performance of the Applied Biosystems HIV-1 Genotyping Kit with Integrase

Hannah P. Moore, Philip J. Palumbo, Kin Israel Notarte, Jessica M. Fogel et autres

HIV genotyping is used to assess HIV susceptibility to antiretroviral drugs. The Applied Biosystems HIV-1 Genotyping Kit with Integrase (AB kit, Thermo Fisher Scientific) detects resistance-associated mutations (RAMs) in HIV protease (PR), reverse transcriptase (RT), and integrase (IN). We compared results from …

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