Jacquelyn Reuther

Utility of circulating tumor DNA in patients with resectable pancreatic cancer using a patient-specific panel: ARTEMIS-PC study.

Keiko KAMEI, Taro Shibuki, Hideaki Bando, Makoto Ueno et autres

747 Background: Tumor-informed circulating tumor DNA (ctDNA) assays for minimal residual disease (MRD) have demonstrated promise across multiple cancers. However, in pancreatic ductal adenocarcinoma (PDAC), clinical utility remains uncertain. We therefore conducted the multicenter prospective ARTEMIS-PC study to evaluate the utility of …

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Paired Exome-Based Comprehensive Genomic Profiling and Germline Genetic Testing for Unselected Patients With Colorectal Cancer in a Multicenter Prospective Study

Pedro Luiz Serrano Uson Junior, Jacquelyn Reuther, Michael A. Golafshar, Megan H. Hawley et autres

Background and Aims: Comprehensive genomic profiling (CGP) for tumors and germline genetic testing (GGT) inform precision therapy and clinical management of patients with colorectal cancer (CRC), and evidence is growing in support of universal paired CGP-GGT patient testing. However, the utility of …

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Abstract 7471: Mutational profiles of pancreatic cancer patients from Eastern Asia using somatic exome sequencing

Jacquelyn Reuther, Taro Shibuki, Megan Hawley, Hideaki Bando et autres

Abstract Introduction: Pancreatic adenocarcinoma (PC) is one of the most lethal diseases. The incidence of PC is rising in the Asia-Pacific population, with some of the highest rates in Japan. As such, the utilization of molecular testing has increased, especially for advanced …

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Anaplastic meningioma in a 6-year-old with somatic YAP1::MAML2 fusion and multiple endocrine neoplasia type 4 (MEN4) syndrome

Lauren Desrosiers, John H. Lee, Izabela Tarasiewicz, Andrea Gilbert et autres

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Utility of circulating tumor DNA in patients with unresectable pancreatic cancer using a patient-specific panel: ARTEMIS-PC study.

Taro Shibuki, Hideaki Bando, Makoto Ueno, Kenji Ikezawa et autres

684 Background: Circulating tumor DNA (ctDNA) analysis has proven to be a highly accurate method for assessing treatment efficacy and detecting molecular residual disease (MRD) in cancer patients, outperforming tumor markers and imaging modalities. However, the ctDNA detection rate is reported to …

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Comparing the Diagnostic Yield of Germline Exome Versus Panel Sequencing in the Diverse Population of the Texas KidsCanSeq Pediatric Cancer Study

Lauren Desrosiers, Tao Wang, Jacquelyn Reuther, George Miles et autres

PURPOSE To evaluate the relative diagnostic yield of clinical germline genomic tests in a diverse pediatric cancer population. PATIENTS AND METHODS The KidsCanSeq study enrolled pediatric cancer patients across six sites in Texas. Germline analysis included both exome sequencing and a therapy-focused …

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Brain abscesses, neutropenia, and B-ALL: Multiple testing modalities required to confirm PDCD10 and ETV6 dual diagnoses

Runjun D. Kumar, Liesbeth Vossaert, Weimin Bi, Nichole Marie Owen et autres

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Anaplastic Meningioma in a 6-Year-Old with Somatic Yap1::Maml2 Fusion and Multiple Endocrine Neoplasia Type 4 (Men4) Syndrome

Lauren Desrosiers, John H. Lee, Izabela Tarasiewicz, Andrea Gilbert et autres

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Recommendations for Cell-Free DNA Assay Validations

Christina M. Lockwood, Laetitia A Borsu, Milena Cankovic, Jonathan S.L. Earle et autres

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Personalized Cancer Monitoring Assay for the Detection of ctDNA in Patients with Solid Tumors

Jianhua Zhao, Jacquelyn Reuther, Kaylee Scozzaro, Megan Hawley et autres

BACKGROUND: assay uses a patient-specific, tumor-informed variant signature identified through whole exome sequencing to detect ctDNA in peripheral blood of patients with solid tumors. METHODS: The assay's tumor whole exome sequencing and ctDNA detection components were analytically validated using 250 unique human …

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Circulating tumor DNA sequencing of pediatric solid and brain tumor patients: An institutional feasibility study

Ross Mangum, Jacquelyn Reuther, Koel Sen Baksi, Ilavarasi Gandhi et autres

The potential of circulating tumor DNA (ctDNA) analysis to serve as a real-time "liquid biopsy" for children with central nervous system (CNS) and non-CNS solid tumors remains to be fully elucidated. We conducted a study to investigate the feasibility and potential clinical …

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Frequency and spectrum of clinically significant molecular alterations detected by tumor gene panel testing for pediatric cancer patients in the Texas KidsCanSeq study.

Frank Y. H. Lin, Jacquelyn Reuther, Samara L. Poplack Potter, Ross Mangum et autres

10018 Background: Tumor sequencing has the potential to inform diagnosis, prognosis, and treatment of childhood cancer patients. Prospective data are needed to evaluate the clinical utility of these tests. Methods: Patients less than 18 years of age with extracranial solid tumors (ST), …

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