Harshita B. Gupta

333 Murine models for triple-negative breast cancer with differential responsiveness to immunotherapy

Thomas J. Kalantzakos, Yufan Zhou, Xingyu Liu, Joshua Proehl et autres

ABSTRACT Breast cancer is the most common cancer diagnosis in women. Clinical studies with triple-negative breast cancer (TNBC) are encouraging for immunotherapy combined with chemotherapy (anti-PD-1 with paclitaxel and/or carboplatin). However, additional clinical advances may be pursued more rapidly with assistance from …

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Collapsing Retroviruses for Efficient Delivery of Viro-Toxic Cargoes

Christopher D. Mullally, Bojana Stefanovska, Yanjun Chen, Harshita B. Gupta et autres

Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNγ signalling

Carlos O. Ontiveros, Myrna G Garcia, Clare Murray, Yilun Deng et autres

The PD-L1 immune checkpoint ligates the PD-1 immune checkpoint, and antibodies against either are effective in treating selected human cancers. Although PD-L2 also ligates PD-1, αPD-L2 is little studied as cancer immunotherapy. We previously showed that αPD-L1 treated young B16-bearing mice but …

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459 Murine breast cancer cell lines with differential responsiveness to immunotherapy

Thomas J. Kalantzakos, Yufan Zhao, Xingyu Liu, Christopher Mullally et autres

Background Breast cancer is the leading cause of cancer mortality among females. 1 APOBEC3 (A3) enzymes, specifically A3A and A3B, deaminate cytosine to uracil in single-stranded DNA, leading to diagnostic mutational signatures in 15-20% of primary tumors and 25-30% of metastases.2 A3 …

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Ligand-receptor interactions induce and mediate regulatory functions of BATF3 + B cells

Hui Min Yan, Rui Wang, Suryavathi Viswanadhapalli, Christian Cervantes et autres

B cells express many protein ligands, yet their regulatory functions are incompletely understood. We profiled ligand expression across murine B sublineage cells, including those activated by defined receptor signals, and assessed their regulatory capacities and specificities through in silico analysis of ligand-receptor …

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Abstract P1-02-25: New Murine Mammary Tumor Cell Lines for Syngeneic Studies Including Immunotherapy

Thomas J. Kalantzakos, Cameron C. Durfee, Chris Mullally, Benjamin Troness et autres

Abstract Breast cancer (BC) is the most common cancer diagnosis in women globally, accounting for more than 1 in 10 new cancer diagnoses. While BC has historically been a poor candidate for immune checkpoint blockade (ICB), recent studies in triple-negative BC (TNBC) …

Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders

Jian Tang, Ramkumar Moorthy, Laura E. Hirsch, Özlem Demir et autres

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554 Differential immunotherapy responses in novel murine breast cancer cell lines

Thomas J. Kalantzakos, Cameron C. Durfee, Benjamin Troness, Harshita B. Gupta et autres

Background Breast Cancer (BC) accounts for over 2 million new cancer diagnoses per year and is the leading cause of cancer mortality among females.1 BC has historically been considered poorly immunogenic with low immune checkpoint blockade (ICB) therapy responsiveness. Encouragingly, recent studies …

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Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors

Clare Murray, Anand V. R. Kornepati, Carlos Ontiveros, Yiji Liao et autres

BACKGROUND: Aside from the canonical role of PDL1 as a tumour surface-expressed immune checkpoint molecule, tumour-intrinsic PDL1 signals regulate non-canonical immunopathological pathways mediating treatment resistance whose significance, mechanisms, and therapeutic targeting remain incompletely understood. Recent reports implicate tumour-intrinsic PDL1 signals in the …

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DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo

Jordan A. Naumann, Prokopios P. Argyris, Michael A. Carpenter, Harshita B. Gupta et autres

Although the APOBEC3 family of single-stranded DNA cytosine deaminases is well-known for its antiviral factors, these enzymes are rapidly gaining attention as prominent sources of mutation in cancer. APOBEC3′s signature single-base substitutions, C-to-T and C-to-G in TCA and TCT motifs, are evident …

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DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo

Jordan A. Naumann, Prokopios P. Argyris, Michael P. Carpenter, Harshita B. Gupta et autres

Although the APOBEC3 family of single-stranded DNA cytosine deaminases are well-known as antiviral factors, these enzymes are rapidly gaining attention as prominent sources of mutation in cancer. APOBEC3 signature single base substitutions, C-to-T and C-to-G in TCA and TCT motifs, are evident …

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Flow cytometry profiling of cellular immune response in COVID-19 infected, recovered and vaccinated individuals

Diksha Kumari, Sayar Singh, Manisha Kumari, Harshita B. Gupta et autres

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