Ashkan Zarrieneh

Dynamic release of extracellular particles after opening of the blood-brain barrier predicts glioblastoma susceptibility to paclitaxel

Mark W. Youngblood, Abha Kumari, Yoon‐Tae Kang, Andrew P. Gould et autres

Liquid biopsies hold promise to improve the diagnosis, assessment of response to therapy, and ultimately guide the management of cancer patients. However, implementation of this approach in brain tumors has proven challenging due to the limited passage of molecules across the blood-brain …

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Data from Pharmacokinetic Analysis of Carboplatin and Fluorescein Brain Retention following Ultrasound-Based Blood–Brain Barrier Opening

Karl John Habashy, Timothy W. Synold, Ye Feng, Cristal Gomez et autres

AbstractPurpose: The blood–brain barrier (BBB) impedes the passage of most circulating drugs into the brain. Low-intensity pulsed ultrasound with microbubbles (LIPU/MB) transiently opens the BBB, improving parenchymal drug penetration. Parenchymal drug retention following short-lived BBB opening is unknown. We investigated the effect …

Pharmacokinetic Analysis of Carboplatin and Fluorescein Brain Retention following Ultrasound-Based Blood–Brain Barrier Opening

Karl John Habashy, Timothy W. Synold, Feng Ye, Cristal Gomez et autres

PURPOSE: The blood-brain barrier (BBB) impedes the passage of most circulating drugs into the brain. Low-intensity pulsed ultrasound with microbubbles (LIPU/MB) transiently opens the BBB, improving parenchymal drug penetration. Parenchymal drug retention following short-lived BBB opening is unknown. We investigated the effect …

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Pharmacokinetic analysis of carboplatin and fluorescein brain permanence following ultrasound-based blood-brain barrier opening

Karl John Habashy, Timothy W. Synold, Feng Ye, Cristal Gomez et autres

Background: The blood-brain barrier (BBB) impedes the passage of most circulating drugs into the brain. Low-intensity pulsed ultrasound with microbubbles (LIPU/MB) transiently opens the BBB, improving parenchymal drug penetration. Parenchymal drug permanence upon short-lived BBB opening is unknown. We compared the parenchymal …

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DDEL-15. PHARMACOKINETIC ANALYSIS OF CARBOPLATIN AND FLUORESCEIN BRAIN PENETRATION AND PERMANENCE FOLLOWING ULTRASOUND-BASED BLOOD-BRAIN BARRIER OPENING ON GLIOBLASTOMA CLINICAL TRIAL

Karl John Habashy, Timothy W. Synold, Feng Ye, Kwang‐Soo Kim et autres

Abstract The blood-brain barrier (BBB) impedes the passage of most circulating drugs into the brain. Low-intensity pulsed ultrasound with microbubbles (LIPU/MB) transiently opens the BBB, improving drug delivery to the brain. The implication of this transient BBB opening on parenchymal drug permanence …

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Abstract TP50: Exception From Informed Consent (EFIC) In Emergency Research: Developing A Community Consultation Plan

Ashkan Zarrieneh, Christina Amidei, Babak S. Jahromi

Background: In emergent situations where patients are neurologically impaired, obtaining informed consent is a challenge. Research-related interventions that may optimize patient outcomes may be delayed or not given. Under the Final Rule, emergency research studies can proceed without informed consent granted that …

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Improvement in Neurocognitive Function in Moyamoya Patients with Surgical Bypass (P6.217)

Alejandro Vargas, Jennifer Orning, Ashkan Zarrieneh, Dilip Kumar Pandey et autres

To establish the role surgical bypass has on neurocognitive function in Moyamoya patients.

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