Fanli Zeng

The Cytopathogenic BVDV Core Protein Binds with ASC-Enhance the Assembly of Inflammasome Complex and GSDMD-Mediated Pyroptosis

Ning He, Hongming Zhou, Jie Yang, Jiying Yin et autres

Bovine viral diarrhea virus (BVDV) infection is associated with inflammatory responses, but the mechanisms underlying inflammasome activation remain unclear. In this study, Madin-Darby bovine kidney (MDBK) cells were used to compare the inflammatory responses induced by the cytopathogenic NADL strain and the …

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Engineering of DAP1 for enhancing the high-temperature fermentation performance of industrial yeast

Ziteng Zhang, Bowen Zhao, Xianni Qi, Yanan Meng et autres

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CRISPRi-mediated silencing of the ABC transporter Ms_5779 compromises cell envelope integrity and impairs intracellular host lipid exploitation

Yuhao Song, Didi Ban, Rui Zhang, Naichao Diao et autres

Background Multidrug-resistant Mycobacterium tuberculosis (MDR-TB) poses a severe global health threat, yet the contribution of cell envelope barriers to intrinsic drug tolerance remains poorly understood. The ABC protein Rv0820 is conserved across mycobacteria but functionally uncharacterized, presenting a structural paradox: it lacks …

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Modular Organization of Rba50 Reveals Distinct Domains for RNAPII Assembly and Interaction Network Formation

Debao Xie, Le Wang, Xizhe Sun, Yuanyuan Yan et autres

RNA polymerase II (RNAPII) is a conserved 12-subunit enzyme essential for eukaryotic transcription. Although the structure and biological functions of RNAPII are well-defined, the mechanisms by which its subunits are assembled into a functional complex remain only partially understood. Several RNAPII assembly …

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Research Advances in the Application of Traditional Chinese Medicine Food-Medicines(Homology of Food and Medicine) in Male Sexual Dysfunction(2020—2025)

Yucheng JIN, Fanli Zeng, Yumin Zhuo

The Traditional Chinese Medicine (TCM) concept of the homology of food and medicine (Yaoshi Tongyuan) holds considerable potential in the management of Male Sexual Dysfunction (MSD) . This approach is grounded in the TCM tenet that there exists no strict demarcation between …

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Correction: Dosage suppressors of gpn2ts mutants and functional insights into the role of Gpn2 in budding yeast

Le Wang, Pan Li, Pei Zeng, Debao Xie et autres

[This corrects the article DOI: 10.1371/journal.pone.0313597.].

Enhancing the quality of corn straw feeds through low-temperature fermentation with synthetic microbial community

Chang Lu, Zhen Li, Xinru Ren, Wenshuo Yan et autres

Solid-state fermentation (SSF) using synthetic microbial communities (SMC) offers a promising approach to converting straw into nutritionally enriched feed. However, the low-temperature environment is one of the major limiting factors that determines the quantity of SSF, particularly in the alpine region. Here, …

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Microbial Differences in Rhizospheric and Ednophytic Microbiota in Healthy Chinese Yam Roots and Those Affected by Yam End Black Disease

Yuwei Liu, Fanli Zeng, Zhimin Hao, Jia Li et autres

Yam end black disease (YEBD) is a devastating soil-borne disease that severely compromises the yield of Chinese yam (Dioscorea opposita Thunb.). Despite its agricultural importance, the etiological agents and molecular mechanisms underlying YEBD remain poorly understood. In this study, we employed an …

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Reversible cytoplasmic foci of RNA polymerase II subunits serve as proteostatic hubs orchestrating transcriptional reprogramming

Le Wang, Debao Xie, Xiangdong Zhao, Xizhe Sun et autres

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Engineering of DAP1 for enhancing the high-temperature fermentation performance of industrial yeast

Ziteng Zhang, Bowen Zhao, X. Y. Qi, Yanan Meng et autres

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Developing a compatible cold-inducible expression system for low-temperature fermentation in Saccharomyces cerevisiae

Zhen Wang, Mengdi Gao, Hongqian Cheng, Zhaoying Li et autres

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Effects of dietary supplementation of Poria cocos polysaccharides on intestinal barrier, immune function, and growth of Hyla rabbits

Wenyi Wei, Xiaolin Yang, Ying Zong, Kun Shi et autres

Introduction Optimal rabbit health, which significantly influences growth and development, depends on three key factors: a robust immune system, proper intestinal function, and balanced gut microbiota. Poria cocos polysaccharide (PCP), the primary bioactive component of Poria cocos , exhibits multiple pharmacological properties …

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