Elizabeth A. Jasper

Genetic variation in macrophage-restricted FOLR2 is associated with neurodevelopmental and reproductive immune phenotypes

Elizabeth A. Jasper, James Jaworski, Yuan Luo, Bahram Namjou Khales et autres

Introduction Folate receptor beta (FRβ), encoded by FOLR2 , is a cell surface receptor with restricted expression in monocytes and macrophages and is highly expressed at the maternal-fetal interface, yet its genetic contributions to human disease remain unexplored. Methods Given the importance …

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Glucagon-Like Peptide-1 Receptor Agonists and Risk of Adverse Maternal Pregnancy Outcomes

Erin Hattler, Hannah Schlüter, Catherine Greene, Margaret A. Adgent et autres

OBJECTIVE: To assess associations between pregestational and early-gestational exposure to glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and maternal pregnancy complications. DATA SOURCES: A comprehensive search across the PubMed and EMBASE databases was conducted from inception to November 2025. METHODS OF STUDY SELECTION: …

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Home pregnancy test sensitivity by test timing and cycle length with real-world use among pregnancy planners who conceived

A Sundermann, Elizabeth A. Jasper, Ryan J. Buckley, Kenneth Rothman et autres

OBJECTIVE: To determine the sensitivity of home pregnancy tests with real-world use by day of testing and cycle length among pregnancy planners who conceived. DESIGN: Pregnancy Study Online (PRESTO, 2018-2024) is an internet-based prospective cohort of pregnancy planners in North America who …

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Genetically predicted cytotrophoblast gene expression is associated with birth weight and adult body mass index

Alyssa C. Parker, Alison J. Eastman, Phillip Lin, Jing Wang et autres

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S-PrediXcan predicted gene expression in human placenta is associated with childhood-onset asthma risk

Elizabeth A. Jasper, Christopher G. McKennan, Emma E. Thompson, Nathan Schoettler et autres

Investigation of in utero, tissue-specific molecular pathways contributing to prenatal programming of childhood-onset asthma is needed to develop effective, targeted prevention strategies. We aimed to examine the relationship between predicted gene expression in placenta and childhood-onset asthma and to compare relationships between …

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Publisher Correction: Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting

Marlena Fejzo, Xinran Wang, Qing Tan, Julia Zöllner et autres

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A randomized trial to evaluate attitudes regarding pharmacogenomics among pregnant and pediatric populations: design and baseline characteristics

Alexandra C. Sundermann, Salisha E. Marryshow Batson, Elizabeth A. Jasper, Sarah H. Jones et autres

Pharmacogenomics (PGx) is a key component of precision medicine, yet most PGx studies exclude pregnant people and children. The VICE (Vanderbilt Integrated Center of Excellence)-MPRINT (Maternal and Pediatric Precision in Therapeutics): Maternal and Pediatric Pharmacogenetics Trial is a single-center, randomized control trial …

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Gestational diabetes mellitus (GDM) in the first-reported pregnancy modifies association between interpregnancy-weight-change and GDM risk in the subsequent pregnancy

Til B. Basnet, Christina R. Dantam, Charles T. Dupont, Eric S. Torstenson et autres

Background Weight change between pregnancies affects gestational diabetes mellitus (GDM) risk in subsequent pregnancies. However, it is unclear whether this impact differs based on the individual’s GDM status in a prior pregnancy. Objectives To evaluate whether prior GDM status modifies the association …

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Genetically-predicted placental gene expression links to uterine fibroids and endometriosis

Alexis T. Akerele, Gabrielle Hampton, Jeewoo Kim, James Jaworski et autres

INTRODUCTION: Mother-to-child disease transmission begins in utero, with the placenta playing a critical role in pregnancy and offspring health. Uterine leiomyomata (fibroids, UFs) and endometriosis (ENDO) are common gynecologic diseases that have substantial overlaps in symptomology and risk factors, however drivers of …

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Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting

Marlena Fejzo, Xinran Wang, Qing Tan, Julia Zöllner et autres

Most pregnancies are affected by nausea and vomiting, but the most severe form-hyperemesis gravidarum-can be life threatening. Here we performed a multi-ancestry genome-wide association study of hyperemesis gravidarum in 10,974 cases and 461,461 controls across European, Asian, African and Latino ancestries. We …

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First-Trimester Bleeding and the Risk of Pregnancy Loss in a Prospective Cohort

A Sundermann, Elizabeth A. Jasper, Paulina E Chumakov, Suchita E. Kumar et autres

Vaginal bleeding in the first trimester is common, but our understanding of how bleeding relates to the risk of pregnancy loss is limited. In a prospective cohort study, participants provided information on bleeding episodes during early pregnancy and underwent a first-trimester research …

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Rapid Genome and Exome Sequencing in Inpatients: Clinical Impact at a Tertiary Academic Medical Center

Cecilia Kessler, Bryce Schuler, Elizabeth A. Jasper, Janet Talbert et autres

The objective of this study is to describe outcomes of rapid exome (rES) and rapid genome sequencing (rGS) in an inpatient setting. This is a retrospective cohort of inpatients with rES or rGS during their hospitalization between April 2016 and November 2023. …

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