T.-S. Liu

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Yanjing Zhu, Luoyan Ai, Shan Chi Yu, Yichen Wang et autres

ARID1A, a component of the SWI/SNF tumor suppressor complex, is frequently mutated in colorectal cancers (CRC). Here, it is found that CRC with ARID1A/TP53 concurrent mutations is highly sensitive to WEE1 inhibitors. ARID1A deficiency promoted the accumulation of R-loops, leading to replication …

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Cross-platform comparison of NGS and MALDI-TOF for detecting RAS/RAF/PIK3CA mutations in circulating tumor DNA from metastatic colorectal cancer patient plasma

Li Liang, Boming Wang, Qian Yu, T.-S. Liu et autres

Background: Evaluating tumor RAS/RAF status is essential for treatment selection and prognosis evaluation in metastatic colorectal cancer (mCRC) patients. Analyzing ctDNA in mCRC patients has many advantages because of its non-invasive nature. However, since the signal of ctDNA is generally low, detection …

cn (code pays fourni par la source)

Lipid tear deficiency in persistent dry eye after laser in situ keratomileusis and treatment results of new warming device

Mario A. Di Pascuale, T.-S. Liu, William Trattler, S-Y Tseng