Giulia Falabella

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Giovanni Luca, Francesca Mancuso, Mario Calvitti, Iva Arato et autres

Porcine Sertoli cells (pSC) have been successfully employed as cell therapy in pre-clinical studies of several immune-based and chronic degenerative diseases. In order to prevent any transmission of infectious adventitious agents to the cells graft recipients, we have set up, according to …

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Sara Chiappalupi, Guglielmo Sorci, Giovanni Luca, Francesca Mancuso et autres

Duchenne muscular dystrophy (DMD), a progressive muscle degenerative disease associated with chronic inflammation, necrosis and fibrosis, is currently treated with antiinflammatory steroids, despite their limited efficacy and undesired side effects. Testicular Sertoli cells (SCs) have been successfully implanted to treat many experimental …

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Giovanni Luca, Stefano Giovagnoli, Francesca Mancuso, Mario Calvitti et autres

Sertoli cells (SC) have been used for their immunomodulatory properties in cell transplants (Emerich et al., 2003). Moreover, SC themselves may prevent immune rejection (Sipone et al., 2006) and possess a natural phagocytic activity: the latter may make them suitable as biocompatible …

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Giovanni Luca, Cinzia Lilli, Catia Bellucci, Francesco Paolo Mancuso et autres

At present, there is no reliable experimental model “in vitro” to analyze the complex interactions between gonadotropins on the pre-pubertal Sertoli cells (SC) and Leydig cells (LD). Considering that, in the pre-pubertal period, only the anti-mullerian hormone (AMH) is upregulated by FSH …

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Giovanni Luca, Cinzia Lilli, Catia Bellucci, Francesca Mancuso et autres

Cadmium, an ubiquitous environmental pollutant mainly used for industrial purposes, is highly associated with reproductive toxicity. Sertoli cells (SC), by providing an appropriate microenvironment for the development of germ cells, play a pivotal role on spermatogenesis regulation (Geoffroy-Siraudin et al. 2012). Aim …

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Giovanni Luca, Giulia Falabella, Mario Calvitti, Stefano Giovagnoli et autres

Recent studies have shown that extracellular vesicles (Ev) are an important mechanism of intercellular communication. In fact, Ev may contain proteins, DNA and mRNA. In particular, the latter play an important role in various biological processes including regulation and cell differentiation [1]. …

Indoleamine 2,3-Dioxygenase 2 Immunohistochemical Expression in Resected Human Non-small Cell Lung Cancer: A Potential New Prognostic Tool

Martina Mandarano, Guido Bellezza, Maria Laura Belladonna, Jacopo Vannucci et autres

Indoleamine 2,3-dioxygenase 2 (IDO2) is an analog of the tryptophan degrading and immunomodulating enzyme indoleamine 2,3-dioxygenase 1 (IDO1). Although the role of IDO1 is largely understood, the function of IDO2 is not yet well elucidated. IDO2 overexpression was documented in some human …

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Testosterone and FSH modulate Sertoli cell extracellular secretion: Proteomic analysis

Francesca Mancuso, Mario Calvitti, Domenico Milardi, Giuseppe Grande et autres

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Isolation and characterization of extracellular vesicles secreted by pre-pubertal Sertoli cells

Giovanni Luca, Giulia Falabella, Mario Calvitti, Stefano Giovagnoli et autres

Recent studies have shown that extracellular vesicles (Ev) are an important mechanism of intercellular communication. In fact, Ev may contain proteins, DNA and mRNA. In particular, the latter play an important role in various biological processes including regulation and cell differentiation [1]. …

Xenograft of microencapsulated Sertoli cells restores glucose homeostasis in db/db mice with spontaneous diabetes mellitus

Giovanni Luca, Iva Arato, Francesca Mancuso, Mario Calvitti et autres

Abstract Background Increased abdominal fat and chronic inflammation in the expanded adipose tissue of obesity contribute to the development of insulin resistance and type 2 diabetes mellitus (T2D). The emerging immunoregulatory and anti‐inflammatory properties of Sertoli cells have prompted their application to …

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Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease

Giovanni Luca, Ilaria Bellezza, Iva Arato, Alba Di Pardo et autres

INTRODUCTION: Immune dysfunction, promoted by pro-inflammatory cytokines, plays a pivotal role in neurodegeneration associated with Huntington's disease. AIMS: The aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of Sertoli cells in Huntington's disease. METHODS: The experimental R6/2 …

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An “in vitro” comparative study of different preparations of follicle-stimulating hormone on porcine pre-pubertal Sertoli cells.

Giovanni Luca, Francesca Mancuso, Iva Arato, Mario Calvitti et autres