Accès ouvert
2026
preprint
OpenAlex
Michael R. Armbruster, Amanda R. Cicali, Carter K. Asef, Nicole A. Rivera-Fuentes et autres
Native ion mobility-mass spectrometry (nIM-MS) enables rapid protein structure and stability analysis, but adoption remains limited by time-consuming offline buffer exchange and manual static nanoelectrospray ionization (nESI) emitter workflows. This low throughput is incompatible with the demands of biotherapeutic development, where many …
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Accès ouvert
2026
article
OpenAlex
Joseph L. Corstvet, David W. Lewis, Dmitry Leontyev, Xin Ma et autres
Ambient ionization mass spectrometry includes numerous techniques, many of which are useful for analyzing lipids in biological samples. We report the development of a triboelectric nanogenerator (TENG)-driven laser ablation electrospray ionization (LAESI) platform, a novel ambient ionization method for the direct analysis …
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Accès ouvert
2025
article
OpenAlex
Adetola H. Adewole, Bhuwan Khatri Chhetri, Ghada M. Abdelwahab, Riya Bhanushali et autres
High Resolution Image Download MS PowerPoint Slide Automated high-throughput screening of a prefractionated extract library of marine macroorganisms identified 239 hits (hit rate 2.5%), including a marine algal extract that blocked the Na v 1.7 channel in a fluorescent-based flux assay. Bioactivity-guided …
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Accès ouvert
2025
article
OpenAlex
Carter K. Asef, Samuel G. Moore, Charles Austin Pickens, Carlos A. Saavedra‐Matiz et autres
High Resolution Image Download MS PowerPoint Slide Newborn screening (NBS) is one of the United States’ largest, most successful preventative public health initiatives, improving outcomes for newborns with inborn errors of metabolism. Most disorders on the Recommended Uniform Screening Panel are screened …
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Accès ouvert
2024
article
OpenAlex
Carter K. Asef, Daniel D. Vallejo, Facundo Machado Fernández
Triboelectric nanogenerators (TENG) are useful devices for converting mechanical motion into electric current using readily available materials. Though the applications for these devices span across many fields, TENG can be leveraged for mass spectrometry (MS) as inexpensive and effective power supplies for …
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Accès ouvert
2023
article
OpenAlex
Carter K. Asef, Markace A. Rainey, Brianna M. Garcia, Gonçalo J. Gouveia et autres
Ion mobility (IM) spectrometry provides semiorthogonal data to mass spectrometry (MS), showing promise for identifying unknown metabolites in complex non-targeted metabolomics data sets. While current literature has showcased IM–MS for identifying unknowns under near ideal circumstances, less work has been conducted to …
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Accès ouvert
2022
article
OpenAlex
Markace A. Rainey, Chandler A. Watson, Carter K. Asef, Makayla R. Foster et autres
Metabolite annotation continues to be the widely accepted bottleneck in nontargeted metabolomics workflows. Annotation of metabolites typically relies on a combination of high-resolution mass spectrometry (MS) with parent and tandem measurements, isotope cluster evaluations, and Kendrick mass defect (KMD) analysis. Chromatographic retention …
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Accès ouvert
2022
article
OpenAlex
Amanda O. Shaver, Brianna M. Garcia, Gonçalo J. Gouveia, Alison M. Morse et autres
Untargeted metabolomics studies are unbiased but identifying the same feature across studies is complicated by environmental variation, batch effects, and instrument variability. Ideally, several studies that assay the same set of metabolic features would be used to select recurring features to pursue …
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Accès ouvert
2022
preprint
OpenAlex
Carter K. Asef, Markace A. Rainey, Brianna M. Garcia, Gonçalo J. Gouveia et autres
ABSTRACT Ion mobility (IM) spectrometry provides semi-orthogonal data to mass spectrometry (MS), showing promise for identifying unknown metabolites in complex non-targeted metabolomics datasets. While current literature has showcased IM-MS for identifying unknowns under near ideal circumstances, less work has been conducted to …
us
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Accès ouvert
2022
preprint
OpenAlex
Markace A. Rainey, Chandler A. Watson, Carter K. Asef, Makayla R. Foster et autres
Abstract Metabolite annotation continues to be the widely accepted bottleneck in non-targeted metabolomics workflows. Annotation of metabolites typically relies on a combination of high resolution mass spectrometry (MS) with parent and tandem measurements, isotope cluster evaluations, and Kendrick mass defect (KMD) analysis. …
us
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Accès ouvert
2022
article
OpenAlex
Susanta Das, Kiyoto Aramis Tanemura, Laleh Dinpazhoh, Mithony Keng et autres
The interpretation of ion mobility coupled to mass spectrometry (IM-MS) data to predict unknown structures is challenging and depends on accurate theoretical estimates of the molecular ion collision cross section (CCS) against a buffer gas in a low or atmospheric pressure drift …
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Accès ouvert
2022
preprint
OpenAlex
Amanda O. Shaver, Brianna M. Garcia, Gonçalo J. Gouveia, Alison M. Morse et autres
ABSTRACT Large-scale untargeted metabolomics studies suffer from individual variation, batch effects and instrument variability, making comparisons of common spectral features across studies difficult. One solution is to compare studies after compound identification. However, compound identification is expensive and time consuming. We successfully …
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