Accès ouvert
2025
article
OpenAlex
Bhargav Teja Nallapu, Kellen K. Petersen, Tianchen Qian, İdris Demirsoy et autres
BACKGROUND AND OBJECTIVES: Among the participants of Alzheimer disease (AD) treatment trials, 40% do not show cognitive decline over 80 weeks of follow-up. Identifying and excluding these individuals can increase power to detect treatment effects. We aimed to develop machine learning-based predictive …
us, tr
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Accès ouvert
2025
article
OpenAlex
Chenzhong Yin, Phoebe E. Imms, Nahian F. Chowdhury, Nikhil N. Chaudhari et autres
Brain age (BA), distinct from chronological age (CA), can be estimated from MRIs to evaluate neuroanatomic aging in cognitively normal (CN) individuals. BA, however, is a cross-sectional measure that summarizes cumulative neuroanatomic aging since birth. Thus, it conveys poorly recent or contemporaneous …
us
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Accès ouvert
2025
article
OpenAlex
Heejong Kim, Batuhan K. Karaman, Qingyu Zhao, Alan Q. Wang et autres
Longitudinal imaging data are routinely acquired for health studies and patient monitoring. A central goal in longitudinal studies is tracking relevant change over time. Traditional methods remove nuisance variation with custom pipelines to focus on significant changes. In this work, we present …
us, ca, jp
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Accès ouvert
2025
article
OpenAlex
Maria do Carmo Menezes Bezerra Duarte, Maria E. Gallegos, América Arveláez, Antonio Eblen-Zajjur
The clinical-related input and processing of intestinal afferents to the spinal cord is not well known. This study aims to develop an electrophysiological experimental animal model to study spinal cord afferents from the colon during clinical-related conditions such as hyperexcitability or ischemia. …
ve, cl
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Accès ouvert
2024
article
OpenAlex
Marvin Petersen, Mirthe Coenen, Charles DeCarli, Alberto De Luca et autres
White matter hyperintensities of presumed vascular origin (WMH) are associated with cognitive impairment and are a key imaging marker in evaluating brain health. However, WMH volume alone does not fully account for the extent of cognitive deficits and the mechanisms linking WMH …
de, nl, us, at, ch, sg, ca
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Accès ouvert
2024
article
OpenAlex
André Altmann, Leon Aksman, Neil P. Oxtoby, Alexandra L. Young et autres
Alzheimer's disease typically progresses in stages, which have been defined by the presence of disease-specific biomarkers: amyloid (A), tau (T) and neurodegeneration (N). This progression of biomarkers has been condensed into the ATN framework, in which each of the biomarkers can be …
gb, us
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Accès ouvert
2021
article
OpenAlex
Maria E. Gallegos, Alex Hermes, Debjani Patra
allele that is endogenously-tagged with GFP just upstream of the stop codon. Moreover, we demonstrate that the UNC-11::GFP fusion protein functions like wild type with an expression pattern similar to UNC-11 antibody staining described previously.
us
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Accès ouvert
2020
preprint
OpenAlex
Kelli Leilani Benedetti, Julia Marie Miller, Rashmi Chandra, Kevin C. Daigle et autres
Abstract Memory, defined as an alteration in behavior towards a stimulus that follows as a consequence of experience, arises when a sensory stimulus is encountered at the same time that the animal experiences a negative or positive internal state. How this coincident …
us
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Accès ouvert
2017
article
OpenAlex
Fiona K. Ritchie, Rhianna Knable, Justin Chaplin, Rhiannon Gursanscky et autres
The disproportionate length of an axon makes its structural and functional maintenance a major task for a neuron. The heterochronic gene lin-14 has previously been implicated in regulating the timing of key developmental events in the nematode C. elegans. Here, we report …
au, us
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Accès ouvert
2012
article
OpenAlex
Maria E. Gallegos, Sanjeev Balakrishnan, Priya Chandramouli, Shaily Arora et autres
Rab monomeric GTPases regulate specific aspects of vesicle transport in eukaryotes including coat recruitment, uncoating, fission, motility, target selection and fusion. Moreover, individual Rab proteins function at specific sites within the cell, for example the ER, golgi and early endosome. Importantly, the …
us
(code pays fourni par la source)
2012
conference-paper
OpenAlex
Maria E. Gallegos, A.. Milne, Carlos L. del Rio, M.. Robles
Abstract Stimulating sandstone formations typically requires a mixture of hydrochloric acid (HCl) and hydrofluoric acid (HF) to dissolve formation damaging minerals. The HF reacts with and dissolves all HCl soluble minerals and, dissolves or partially dissolves siliceous materials such as bentonite and …
vg
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Accès ouvert
2012
article
OpenAlex
Damien M. O’Halloran, O. Scott Hamilton, Jin I. Lee, Maria E. Gallegos et autres
The Protein Kinase G, EGL-4, is required within the C. elegans AWC sensory neurons to promote olfactory adaptation. After prolonged stimulation of these neurons, EGL-4 translocates from the cytosol to the nuclei of the AWC. This nuclear translocation event is both necessary …
us
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