Accès ouvert
2025
article
OpenAlex
Kate Chander Chiang, C Chiu, Mazharul Altaf, Mark T. K. Cheng et autres
Early studies on the evolution of SARS-CoV-2 revealed mutations that favored host transmission of the virus and more efficient viral entry. However, cell-free virus spread is vulnerable to host-neutralizing antibodies. As population immunity developed, mutations that confer escape from neutralization were selected. …
ie, gb, hk, Afrique du Sud
(code pays fourni par la source)
2023
conference-abstract
OpenAlex
Kaylee B. Worlock, Robert Lindeboom, Masahiro Yoshida, Lisa M. Dratva et autres
Despite the rapid development and rollout of first-generation vaccines, COVID-19 remains an ongoing global health concern. Whilst single cell transcriptional studies have provided deep biological insights, limited longitudinal sampling has made temporal inferences difficult. The Human COVID-19 Challenge Study offers a unique …
gb
(code pays fourni par la source)
2022
conference-abstract
OpenAlex
Alexander J Mann, Ben Killingley, Mariya Kalinova, Arun Anandakumar et autres
Rationale: To establish a novel SARS-CoV-2 human challenge model enabling controlled investigation of pathogenesis, correlates of protection and efficacy testing of interventions. Methods: Thirty-six healthy 18-29-year-old subjects, without evidence of previous infection or vaccination, received 10 TCID50 of a wild-type virus (SARS-CoV-2/human/GBR/484861/2020) …
gb
(code pays fourni par la source)