Sainiteesh Maddineni

Pediatric Single‐Sided Deafness Workup and Management After Indication Changes for Unilateral Cochlear Implants

Sainiteesh Maddineni, Kristina M. Ward, Beverly J. Fu, Shayna P. Cooperman et autres

ABSTRACT Objective In July 2019, the Food and Drug Administration (FDA) approved unilateral cochlear implantation (CI) in children aged 5 years and older with single‐sided deafness (SSD). In this study, we evaluate how the care of children with SSD evolved after this …

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Cohort study of opioid utilization in post-tonsillectomy pediatric patients

Sainiteesh Maddineni, Varun Vendra, Hareem Khan, Noor Ali et autres

OBJECTIVES: Prospective observational cohort study at a tertiary care academic center to evaluate the post-operative use of oxycodone in pediatric tonsillectomy patients and caregiver knowledge of opioid disposal. METHODS: Pediatric patients 6-18 years old undergoing tonsillectomy were enrolled. Patients were excluded if …

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CD39 + CD49a + CD103 + cytotoxic tissue-resident natural killer cells infiltrate and control solid epithelial tumor growth in mice

Nina B. Horowitz, Imran Mohammad, June Ho Shin, John W. Hickey et autres

Human tissue-resident natural killer (NK) cells (trNK cells), broadly defined by markers of tissue residency, such as CD49a [ integrin α 1 ( ITGA1 )] and CD103 [ integrin α E ( ITGAE )], are increasingly recognized for their immunoregulatory role in …

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Predictive Value of Ipratropium Responsiveness on Posterior Nasal Nerve Neurectomy Outcomes in Chronic Rhinitis

Sainiteesh Maddineni, Peter H. Hwang, Noel Ayoub, Zara M. Patel et autres

OBJECTIVE: Procedures targeting the posterior nasal nerve (PNN) are effective in treating chronic rhinitis after failed medical therapy. We evaluate how ipratropium response predicts PNN intervention outcomes. STUDY DESIGN: Retrospective review from January 2013 to June 2025. STUDY SETTING: Tertiary academic center. …

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Correction: Validation of the Melanoma Institute of Australia’s Sentinel Lymph Node Biopsy Risk Prediction Tool for Cutaneous Melanoma

Sainiteesh Maddineni, Matthew P. Dizon, Vijaytha Muralidharan, Lexi A. Young et autres

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ACTL6A regulates the Warburg effect through coordinated activation of AP-1 signaling in head and neck squamous cell carcinoma

Mehri Monavarian, Imran Mohammad, Sainiteesh Maddineni, Mao Zhang et autres

ACTL6a is an essential component of SWI/SNF and expressed on the chromosome 3q26 cytoband, which is amplified in head and neck squamous cell carcinomas (HNSCC). While ACTL6A is emerging as an oncogene, its role as a treatment target and mechanisms of transcription …

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VISTA immune checkpoint blunts radiotherapy-induced antitumor immune response

Dhanya K. Nambiar, Sainiteesh Maddineni, Jimpi Langthasa, Hongbin Cao et autres

Radiotherapy (RT) is a key treatment for solid neoplasms like head and neck cancer (HNC), but it can also activate and recruit immunosuppressive myeloid cells, causing treatment failure. In this study, we examine the role of V-domain immunoglobulin suppressor of T cell …

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RISK FACTORS FOR ESOPHAGEAL STRICTURING STATUS POST TOTAL LARYNGECTOMY: A SYSTEMATIC REVIEW AND META-ANALYSIS

Jordan Stellern, Michaele Francesco Corbisiero, Joseph M. Gaballa, Andy Ai et autres

An intraepithelial ILC1-like natural killer cell subset produces IL-13

Sainiteesh Maddineni, Krishna Sharma, Imran Mohammad, Alistaire D. Ruggiero-Sherman et autres

Natural killer (NK) cells are innate immune effectors with considerable heterogeneity and potent antitumor capabilities. Intraepithelial ILC1 (ieILC1)-like NK cells, a population of cytotoxic tissue-resident innate lymphoid cells, have recently been documented in the microenvironment of head and neck squamous cell carcinomas …

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Comparison of Technetium-99m Tilmanocept to Technetium-99 Sulfur Colloid Radiotracer for Sentinel Lymph Node Biopsy in Head and Neck Melanoma

Sainiteesh Maddineni, Sofia Tosoni, John B. Sunwoo, Fred M. Baik

Background: Sentinel lymph node biopsy (SLNB) is integral to management of head and neck melanomas (HNM). Here, we evaluate how radiotracer selection (Tc-99m tilmanocept or Tc-99m sulfur colloid) and imaging modality (planar imaging or single positron emission computed tomography (SPECT)) may influence …

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Intraepithelial ILC1‐Like NK Cells Increase Lymphocyte Infiltration into the Tumor Microenvironment via the CXCL10 Axis

Sainiteesh Maddineni, Krishna Sharma, Imran Mohammad, June Ho Shin et autres

Intraepithelial type 1 innate lymphoid cells (ieILC1s) are tissue-resident lymphocytes in the microenvironment of head and neck squamous cell carcinoma. Here, we evaluate how these cells influence T-cell trafficking to tumors. We generated cytotoxic ieILC1-like cells from natural killer (NK) cells in …

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Posterior nasal nerve surgical neurectomy versus ablation for chronic rhinitis

Sainiteesh Maddineni, Peter H. Hwang, Zara M. Patel, Jayakar V. Nayak et autres

INTRODUCTION: For chronic rhinitis (CR) refractory to medical management, several ablative procedures exist that target the posterior nasal nerve (PNN). Here we compare outcomes of PNN surgical neurectomy to in-office ablative procedures. METHODS: We retrospectively reviewed patients with CR who trialed ipratropium …

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