Tong Xu

Construction and Immunogenicity of a Recombinant Pseudorabies Virus Expressing the Major Neutralizing Epitopes A and D of Transmissible Gastroenteritis Virus Spike Protein

Li Zhao, Xiang-Shuo Tian, Tong Xu, Xiao-zhan ZHANG et autres

Transmissible gastroenteritis (TGE) and pseudorabies (PR) remain important viral diseases causing massive economic losses and posing a continuous burden on the global swine industry. The continuous emergence of variant strains of transmissible gastroenteritis virus (TGEV) and pseudorabies virus (PRV) has gradually weakened …

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Enrichment risk and drivers of manure-derived antibiotic resistance genes in black soldier fly larval gut

Yiwen Yang, Yanhong Guo, Tong Xu, Yongbao Wu et autres

Black soldier fly larvae (BSFL) are promising for converting animal manure into protein; however, the risk of antibiotic resistance gene (ARG) enrichment in the larval gut during this process remains unclear. Here, we employed metagenomic and metatranscriptomic analyses to investigate this risk …

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MYC2 interacts with JMJC3 to modulate jasmonate‐regulated thermotolerance in tomato

Tong Xu, Tingting Ran, Ying Shi, Fengjun Yang et autres

Heat stress is a major environmental challenge affecting agricultural productivity and food security. The jasmonate (JA)-myelocytomatosis protein 2 (MYC2) pathway plays a critical role in plant growth and stress response. However, the mechanisms of how the JA-MYC2 pathway participates in the heat …

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Sucrose‐Induced Transcription Factor IjSUSIBA2 Fine‐Tunes Growth Transition Through the IjSVL2‐IjFLCL1 Module in Evergreen Irises

Lingmei Shao, Tong Xu, Xiaobin Wang, Xiaoxuan Chen et autres

Sugar metabolism is commonly implicated as crucial in the transition between growth and cessation during winter; however, its exact role remains elusive. The evergreen iris (Iris japonica) ceases growth in winter without entering endodormancy, yet it continues to sustain sugar metabolism and …

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Chemoradiotherapy followed by continued immunotherapy for out-of-field progression during consolidation in limited-stage SCLC: a case report

Ying Jiang, Tong Xu, Nan Bi

Background: While consolidation immunotherapy after chemoradiotherapy (CRT) improves survival in limited-stage small cell lung cancer (LS-SCLC), some patients develop out-of-field progression during consolidation. Optimal management in such cases remains undefined. Case presentation: We describe a 49-year-old male with LS-SCLC who developed supraclavicular …

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Phosphoproteomics Maps Calcineurin-NFAT-DSCR1.4 Signaling as Druggable Axis in Gαq-R183Q–Driven Capillary Malformations

Tong Xu, Vera Janssen, Nathalie R. Reinhard, Paula Sobrevals-Alcaraz et autres

Abstract Vascular malformations are congenital lesions caused by somatic and germline mutations that disrupt developmental signaling pathways. Capillary malformations (CMs) typically present as port-wine stains in the skin and can also affect ocular and cerebral tissues in Sturge Weber Syndrome (SWS), leading …

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Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replication in vitro

Zhanding Cui, Jinyi Liu, Jinlong Wang, Jing Zhang et autres

This study delves into the antiviral efficacy of Formononetin (FMN) and Mizoribine (MZR) against the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), a virus with a considerable economic impact and a current void in effective treatments. FMN and MZR were found to …

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An Efficient and Environmentally Friendly Strategy for Embryogenic Callus Induction and Plant Regeneration of Iris pseudacorus L.

Danqin Li, Chenxi Ji, Lingmei Shao, Tong Xu et autres

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Isolation and Characterization of a Porcine Getah Virus Strain from Sichuan Province

Lina Shao, Mincai Nie, Baoling Liu, Fengqin Li et autres

Following its initial documented emergence in Hunan’s swine facilities in 2017, GETV has inflicted considerable financial damage upon China’s pork production sector. Beyond its impact on swine, GETV also poses a potential risk to other animal species and public health, primarily due …

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Getah virus triggers ROS-mediated autophagy in mouse Leydig cells

Fengqin Li, Lishuang Deng, Tong Xu, Lei Xu et autres

Introduction Getah virus (GETV) is a zoonotic virus transmitted via a mosquito-vertebrate cycle. While previous studies have explored the epidemiology and pathogenicity of GETV in various species, its molecular mechanisms remain largely unexplored. Methods This study investigated the impact of GETV infection …

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Research for the Characterization of Textile-Based Strain Sensors for Human Motion Monitoring

Hao Dou, Lihui Xu, Hong Pan, Tong Xu et autres

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Transcriptome analysis reveals that PRV XJ delgE/gI/TK protects against intestinal damage in nose-dropping-infected mice by regulating ECM-ITGA/ITGB-P-FAK

Tong Xu, Yang Zhang, Qian Tao, Lei Xu et autres

Pseudorabies virus (PRV) is an ideal model for mechanistic investigations into α-herpesvirus. The neurotropism and latent infection of PRV have been extensively studied. Apart from neurological symptoms, diarrhea caused by PRV infection is also an essential cause of mortality in newborn and …

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