Ľubica Lacinová

Effects of pre-gestational exposure to the stressors and perinatal mirtazapine administration on the excitability of hippocampal glutamate and brainstem monoaminergic neurons, hippocampal neuroplasticity, and anxiety-like behavior in rats

Ruslan Paliokha, Mireia Viñas-Noguera, Stanislava Bukatová, Daniil Grinchii et autres

When accompanied by excessive exposure to the stressors, pregnancy may result in prenatal depression, that has in turn negative influence on the offspring's brain. Mirtazapine, among other antidepressants, is commonly used to treat prenatal depression. Even though mirtazapine is generally considered safe …

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Homocysteine enhances the excitability of cultured hippocampal neurons without altering the gene expression of voltage-gated ion channels

Alzbeta Filipova, Matúš Tomko, Katarína Ondáčová, Lucia Hoppanová et autres

Elevated plasma homocysteine (Hcy) levels lead to hyperhomocysteinemia, a condition associated with various neurological disorders affecting multiple brain regions, including the hippocampus. In this study, we investigated the effects of exposing cultured rat hippocampal neurons to Hcy concentrations corresponding to mild, moderate, …

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Pregestational Stress Representing a Maternal Depression Model and Prenatally Applied Antidepressant Mirtazapine Modulate Hippocampal Excitability in Offspring

Lucia Hoppanová, Alzbeta Filipova, Stanislava Bukatová, Katarína Ondáčová et autres

Maternal depression negatively affects the neurodevelopment of offspring, but its pharmacological treatment during gestation remains controversial. This study reports the consequences of maternal depression and/or prenatal antidepressant treatment with mirtazapine on offspring early neurodevelopment via an animal model of maternal depression induced …

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EFFECTS OF PRENATAL AND POSTNATAL TREATMENT WITH A DELTA- OPIOID RECEPTOR LIGAND ON ANXIETY, COGNITION AS WELL AS MESOLIMBIC DOPAMINERGIC AND HIPPOCAMPAL GLUTAMATERGIC NEUROTRANSMISSION IN RATS

Henrieta Oravcová, Daniil Grinchii, Zuzana Romanova, Ľubica Lacinová et autres

Abstract Background Central neurotransmitters are well-known to be involved in the pathophysiological processes leading to mental disorders. It is suggested that activation of delta opioid receptors (DOR) may lead to anxiolytic and antidepressant-like effects. The interaction between these brain regulatory systems is …

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Pregestational Stress Representing a Maternal Depression Model and Prenatally Applied Antidepressant Mirtazapine Modulate Hippocampal Excitability in the Offspring

Lucia Hoppanová, Stanislava Bukatová, Katarína Ondáčová, Matúš Tomko et autres

Maternal depression negatively affects the neurodevelopment of offspring, but its pharmacological treatment during gestation remains controversial. This study reports the consequences of maternal depression and/or prenatal antidepressant treatment with mirtazapine on offspring early neurodevelopment via an animal model of maternal depression induced …

sk (code pays fourni par la source)

Effects of pre-gestational exposure to the stressors and perinatal mirtazapine administration on the excitability of hippocampal glutamate and brainstem monoaminergic neurons, hippocampal neuroplasticity, and anxiety-like behavior in rats

Eliyahu Dremencov, Ruslan Paliokha, Mireia Viñas-Noguera, Stanislava Bukatová et autres

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Peer Review Report For: Analysis of hippocampal synaptic function in a rodent model of early life stress [version 1; peer review: 1 approved, 2 approved with reservations]

Ľubica Lacinová

Maternal treatment with a selective delta-opioid receptor agonist during gestation has a sex-specific pro-cognitive action in offspring: mechanisms involved

Eliyahu Dremencov, Henrieta Oravcová, Daniil Grinchii, Zuzana Romanova et autres

Background: There is growing evidence that the treatment of several mental disorders can potentially benefit from activation of delta-opioid receptors. In the future, delta-agonists with a safe pharmacological profile can be used for the treatment of mood disorders in pregnant women. However, …

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Effects of pre-gestational exposure to the stressors and perinatal bupropion administration on the firing activity of serotonergic neurons and anxiety-like behavior in rats

Daniil Grinchii, Kristína Csatlósová, Mireia Viñas-Noguera, Roman Dekhtiarenko et autres

Exposure by women to stressors before pregnancy increases their risk of contracting prenatal depression, a condition which typically may require antidepressant treatment. And even though such perinatal antidepressant treatment is generally considered to be safe. For the mother, its effects on the …

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Effects of chronic delta-opioid receptor agonist on the excitability of hippocampal glutamate and brainstem monoamine neurons, anxiety, locomotion, and habituation in rats

Eliyahu Dremencov, Daniil Grinchii, Zuzana Romanova, Pavol Chomanic et autres

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Stress, depression, and hippocampus: from biochemistry to electrophysiology

Alzbeta Idunkova, Ľubica Lacinová, Lucia Hoppanová

Major depressive disorder is a very common serious mental illness with increasing prevalence in the population. Its pathology includes biochemical, morphological, and electrophysiological changes in various brain areas. In spite of decades of extensive research pathophysiology of depression is still not sufficiently …

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Effects of the acute administration of delta-opioid receptor ligands on the excitability of rat hippocampal glutamate and brainstem monoamine neurons in vivo

Daniil Grinchii, Ľubica Lacinová, Eliyahu Dremencov

It was previously reported that the delta opioid receptor (DOR) agonist SNC80 and antagonist naltrindole modulate the excitability of hippocampal glutamate neurons in primary cultures. The present study aimed to investigate the acute effects of these ligands on the firing activity of …

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