Orthogonal CRISPR screens and human liver chimeric mice identify hepatitis B virus host factors
Catherine A. Freije, Georgios Dangas, Antonis Athanasiadis, Evgenia Moschogianni et autres
Abstract Hepatitis B virus (HBV) chronically infects approximately 250 million people worldwide, and reliable curative therapies are lacking. A broader understanding of viral-host interactions could accelerate efforts to find new host-centric therapeutic targets. However, inefficient cell culture systems and limited replication markers …
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bioRxiv (Cold Spring Harbor Laboratory)