Marc D. Roy

Supplementary Data from Myocarditis in Cynomolgus Monkeys Following Treatment with Immune Checkpoint Inhibitors

Changhua Ji, Marc D. Roy, Jonathan Golas, Allison Vitsky et autres

Table S1. Mean ({plus minus}SD) Toxicokinetic Parameters for Ipilimumab and Novolumab in Cynomolgus Monkeys Table S2 - Differentially expressed genes in the heart of ipilimumab and nivolumab treated cynos (adjusted P-value {less than or equal to} 0.05) Table S3 - Top 50 …

Supplementary Figures from Myocarditis in Cynomolgus Monkeys Following Treatment with Immune Checkpoint Inhibitors

Changhua Ji, Marc D. Roy, Jonathan Golas, Allison Vitsky et autres

Supplemental Figure S1. Concentration versus time profiles of ipilimumab and nivolumab following four weekly intravenous dose administrations of 15 mg/kg or 20 mg/kg, respectively. Supplementary Figure S2. Hematoxylin and eosin stained sections of tissues from control and monkeys dosed with ipilimumab and …

Supplementary Data from Myocarditis in Cynomolgus Monkeys Following Treatment with Immune Checkpoint Inhibitors

Changhua Ji, Marc D. Roy, Jonathan Golas, Allison Vitsky et autres

Table S1. Mean ({plus minus}SD) Toxicokinetic Parameters for Ipilimumab and Novolumab in Cynomolgus Monkeys Table S2 - Differentially expressed genes in the heart of ipilimumab and nivolumab treated cynos (adjusted P-value {less than or equal to} 0.05) Table S3 - Top 50 …

Data from Myocarditis in Cynomolgus Monkeys Following Treatment with Immune Checkpoint Inhibitors

Changhua Ji, Marc D. Roy, Jonathan Golas, Allison Vitsky et autres

AbstractPurpose: Immune checkpoint inhibitors (ICI) targeting PD1, PDL1, or CTLA4 are associated with immune-related adverse events (irAE) in multiple organ systems including myocarditis. The pathogenesis and early diagnostic markers for ICI-induced myocarditis are poorly understood, and there is currently a lack of …

Data from Myocarditis in Cynomolgus Monkeys Following Treatment with Immune Checkpoint Inhibitors

Changhua Ji, Marc D. Roy, Jonathan Golas, Allison Vitsky et autres

AbstractPurpose: Immune checkpoint inhibitors (ICI) targeting PD1, PDL1, or CTLA4 are associated with immune-related adverse events (irAE) in multiple organ systems including myocarditis. The pathogenesis and early diagnostic markers for ICI-induced myocarditis are poorly understood, and there is currently a lack of …

Supplementary Figures from Myocarditis in Cynomolgus Monkeys Following Treatment with Immune Checkpoint Inhibitors

Changhua Ji, Marc D. Roy, Jonathan Golas, Allison Vitsky et autres

Supplemental Figure S1. Concentration versus time profiles of ipilimumab and nivolumab following four weekly intravenous dose administrations of 15 mg/kg or 20 mg/kg, respectively. Supplementary Figure S2. Hematoxylin and eosin stained sections of tissues from control and monkeys dosed with ipilimumab and …

NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells

Kenneth G. Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan et autres

Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive. Here, we develop NOTCH3-targeted antibody drug conjugates (NOTCH3-ADCs) by bioconjugation of an auristatin microtubule inhibitor through a protease cleavable linker to two …

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Expression of Hematopoietic Stem and Endothelial Cell Markers in Canine Hemangiosarcoma

Satoko Kakiuchi-Kiyota, Leslie Obert, Danielle M. Crowell, Shu‐Hua Xia et autres

Several chemicals and pharmaceuticals increase the incidence of hemangiosarcomas (HSAs) in mice, but the relevance to humans is uncertain. Recently, canine HSAs were identified as a powerful tool for investigating the pathogenesis of human HSAs. To characterize the cellular phenotype of canine …

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Myocarditis in Cynomolgus Monkeys Following Treatment with Immune Checkpoint Inhibitors

Changhua Ji, Marc D. Roy, Jonathan Golas, Allison Vitsky et autres

PURPOSE: Immune checkpoint inhibitors (ICI) targeting PD1, PDL1, or CTLA4 are associated with immune-related adverse events (irAE) in multiple organ systems including myocarditis. The pathogenesis and early diagnostic markers for ICI-induced myocarditis are poorly understood, and there is currently a lack of …

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Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing

Romain Rouet, Benjamin A. Thuma, Marc D. Roy, Nathanael G. Lintner et autres

CRISPR-Cas RNA-guided endonucleases hold great promise for disrupting or correcting genomic sequences through site-specific DNA cleavage and repair. However, the lack of methods for cell- and tissue-selective delivery currently limits both research and clinical uses of these enzymes. We report the design …

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Receptor‐Mediated Delivery of CRISPR‐Cas9 Endonuclease for Cell Type Specific Gene Editing

Marc D. Roy, Romain Rouet, Benjamin A. Thuma, Nathanael G. Lintner et autres

CRISPR‐Cas RNA‐guided endonucleases hold great promise for disrupting or correcting genomic sequences through site‐specific DNA cleavage and repair. However, the lack of methods for cell‐ and tissue‐selective delivery currently limits both research and clinical uses of these enzymes. Here we report the …

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α5 nAChR modulation of the prefrontal cortex makes attention resilient

William M. Howe, Julie L. Brooks, Patrick L. Tierney, Jincheng Pang et autres

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