Different response to catecholamine in canine arteries and veins
Hideaki Itoh, Kota Kato, K. Taniguchi, Sol I. Rajfer
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Hideaki Itoh, Kota Kato, K. Taniguchi, Sol I. Rajfer
Roberto Miguel Lang, Robert DiBianco, George T Broderick, Stephen S. Gottlieb et autres
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THERAPEUTIC USE OF ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITORS: ACE inhibitors are now accepted as valuable therapeutic agents in the management of heart failure. The benefits include symptomatic relief, improvement in left ventricular function, prevention of progressive ventricular dilation, improved survival and decreased …
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J D Kohli, J. L. McNay, Sol I. Rajfer, Michael B. Murphy
ogy and Medicine and Chairman of the Committee on Clinical Pharmacology at The
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John D. Carroll, Sanjeev G. Shroff, Phyllis Wirth, M Halsted et autres
The effects of aging on arterial mechanical properties and the response to nitroprusside were examined in 25 patients with dilated cardiomyopathy. High-fidelity pressures were recorded with a multisensor catheter. Pulse wave velocity was determined between two sensors in the thoracic aorta. Arterial …
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The existence of two dopamine receptor subtypes (DA1 and DA2) has been firmly established. Activation of DA1 receptors is associated with vasodilation, primarily in the renal, mesenteric, cerebral, and coronary arterial beds, and a natriuresis. DA2 receptors located on postganglionic sympathetic nerves …
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George T Broderick, Sol I. Rajfer
The successful treatment of congestive heart failure with intravenous dopamine in the acute setting has prompted investigation into the development and use of oral dopamine analogs. The administration of dopamine can lead to an improvement in myocardial pump performance through a combination …
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Roberto M. Lang, Kenneth M. Borow, Alexander L. Neumann, John D. Carroll et autres
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Roberto Miguel Lang, John D. Carroll, Sakie Nakamura, Hideaki Itoh et autres
Although both dopamine and dobutamine are potent positive inotropic agents, multiple studies indicate that dopamine may produce a rise in left ventricular (LV) filling pressure, while dobutamine often has the opposite effect. To ascertain the pharmacological and hemodynamic mechanisms responsible for the …
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Kenneth M. Borow, Roberto Miguel Lang, Angélica Paula Neumann, John D. Carroll et autres
Clinical trials in patients with dilated cardiomyopathy (DCM) have shown a wide disparity in the hemodynamic responses to positive inotropic therapy. In addition, the response of the failing left ventricle to positive inotropic agents reflects the net interaction of multiple factors, including …
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