Michael S. Shtutman

Spatially Constrained Monte Carlo Permutation Test Reveals Diffusion Changes Near Stress Granules

Elizaveta Korunova, Vitali Sikirzhytski, Jeffery L. Twiss, Michael S. Shtutman et autres

Abstract Intracellular diffusion is inherently heterogeneous, yet single-particle tracking (SPT) analyses are often summarized using cell-wide average parameters that can obscure localized effects. Here, we tracked 40-nm genetically encoded multimeric (GEM) nanoparticles during stress granule (SG) formation and developed SPaCe-MC (Spatially Constrained …

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Evaluating methylphenidate as a potential treatment for cocaine use disorder: a propensity score-matched study

Joseph Magagnoli, Tammy H. Cummings, Michael D. Wyatt, Michael S. Shtutman et autres

Background: Cocaine’s psychoactive effects arise primarily from dopamine transporter (DAT) inhibition. Prior trials suggest methylphenidate, a DAT inhibitor with pharmacologic overlap with cocaine, may reduce cocaine use, but real-world data are limited.Objectives: To evaluate whether methylphenidate exposure is associated with reduced likelihood …

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Evaluating methylphenidate as a potential treatment for cocaine use disorder: a propensity score-matched study

Joseph Magagnoli, Tammy H. Cummings, Michael D. Wyatt, Michael S. Shtutman et autres

Background: Cocaine’s psychoactive effects arise primarily from dopamine transporter (DAT) inhibition. Prior trials suggest methylphenidate, a DAT inhibitor with pharmacologic overlap with cocaine, may reduce cocaine use, but real-world data are limited. Objectives: To evaluate whether methylphenidate exposure is associated with reduced …

Evaluating methylphenidate as a potential treatment for cocaine use disorder: a propensity score-matched study

Joseph Magagnoli, Tammy H. Cummings, Michael D. Wyatt, Michael S. Shtutman et autres

Background: Cocaine’s psychoactive effects arise primarily from dopamine transporter (DAT) inhibition. Prior trials suggest methylphenidate, a DAT inhibitor with pharmacologic overlap with cocaine, may reduce cocaine use, but real-world data are limited. Objectives: To evaluate whether methylphenidate exposure is associated with reduced …

Evaluating the Impact of Blood–Brain Barrier-Penetrant ACE Inhibitors on HIV-Associated Neurocognitive Disorders

Tammy H. Cummings, Joseph Magagnoli, Sasha Sikirzhytskaya, Ilya Tyagin et autres

BACKGROUND: As people with HIV (PWH) live longer because of effective antiretroviral therapy, age-related comorbidities-including cognitive impairment-are increasingly prevalent. HIV-associated neurocognitive disorders (HAND) remain a major cause of morbidity. In prior work, we identified an association between blood-brain barrier (BBB)-penetrant angiotensin-converting enzyme …

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Biomedical Hypothesis Explainability with Graph-Based Context Retrieval

Ilya Tyagin, Saeideh Valipour, Aliaksandra Sikirzhytskaya, Michael S. Shtutman et autres

Abstract We introduce an explainability method for biomedical hypothesis generation systems, built on top of the novel Hypothesis Generation Context Retriever framework. Our approach combines semantic graph-based retrieval and relevant data-restrictive training to simulate real-world discovery constraints. Integrated with large language models …

Biomedical Hypothesis Explainability with Graph-Based Context Retrieval

Ilya Tyagin, Saeideh Valipour, Aliaksandra Sikirzhytskaya, Michael S. Shtutman et autres

We introduce an explainability method for biomedical hypothesis generation systems, built on top of the novel Hypothesis Generation Context Retriever framework. Our approach combines semantic graph-based retrieval and relevant data-restrictive training to simulate real-world discovery constraints. Integrated with large language models (LLMs) …

Ending the HIV Epidemic with Low Dose Total Body Irradiation in Combination with Anti-Microtubule Therapy

K. Doxsee, Steven G. Self, Prerana Roth, J. R. Henderson et autres

DEAD-Box Helicase 3 Modulates the Non-Coding RNA Pool in Ribonucleoprotein Condensates During Stress Granule Formation

Elizaveta Korunova, B. Celia Cui, Hao Ji, Aliaksandra Sikirzhytskaya et autres

Stress granule formation is a type of liquid-liquid phase separation in the cytoplasm, leading to RNA-protein condensates that are associated with various cellular stress responses and implicated in numerous pathologies, including cancer, neurodegeneration, inflammation, and cellular senescence. One of the key components …

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AI-based mining of biomedical literature: Applications for drug repurposing for the treatment of dementia

Aliaksandra Sikirzhytskaya, Ilya Tyagin, S. Scott Sutton, Michael D. Wyatt et autres

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Single-particle tracking of genetically encoded nanoparticles: Optimizing expression for cytoplasmic diffusion studies

Elizaveta Korunova, Vitali Sikirzhytski, Jeffery L. Twiss, Paula A. Vásquez et autres

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Ai-Based Mining of Biomedical Literature: Applications for Drug Repurposing for the Treatment of Dementia

Aliaksandra Sikirzhytskaya, Ilya Tyagin, S. Scott Sutton, Michael D. Wyatt et autres

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