Holly Jane Pederson

Rethinking Hereditary Cancer Testing Eligibility: A Five-Domain Framework Beyond Family History Gating

Kevin Michael Capehart, Holly Jane Pederson, Kristina Shaffer, Cameron Drew Friedman

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Menopausal hormone therapy in breast cancer survivors: A review

Lauren M. Granat, Holly Jane Pederson, Megan Lynn Kruse

The use of menopausal hormone therapy (MHT) by breast cancer survivors remains controversial. While MHT is effective for the management of menopausal symptoms in the general population, its safety after breast cancer is uncertain due to limited and heterogeneous data. Menopausal symptoms, …

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Treating Genitourinary Syndrome of Menopause in Postmenopausal Women with a History of Breast Cancer

Dewonna Ferguson, Holly Jane Pederson, Juliana M. Kling

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Breast cancer screening in midlife and beyond

Holly Jane Pederson

WHAT’S NEW IN BREAST CANCER SCREENING? The past year added scrutiny and legality to already inconsistent US breast cancer screening guidelines. Taking effect in 2025, practitioners ordering mammograms must manage now mandatory (and often inexact) risk assessments performed in breast imaging, recognize …

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Polygenic risk scores for breast cancer: Progress, challenges, and clinical integration

Jerry S. S. Lanchbury, Holly Jane Pederson

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Considerations for hormone therapy use in survivors of breast cancer

Holly Jane Pederson

The use of hormone therapy in survivors of breast cancer is complex and contentious. Historically, guidelines have strongly advised against using hormone therapy. Its safety likely depends on many factors. However, long-term oncologic data are lacking, leaving women with unresolved quality-of-life and …

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Abstract P3-02-10: Evaluation of a polygenic risk score as a predictor of breast cancer, triple-negative breast cancer, and early-onset disease in Hispanic women

Holly Jane Pederson, Matthew T. Kucera, Eudora Hu, Brooke Hullinger et autres

Abstract Background: Hispanic women in the U.S. have a lower incidence of breast cancer (BC) when compared to non-Hispanic white (NHW) women. However, Hispanic women diagnosed with BC tend to be younger, have more advanced disease at presentation, and have a higher …

Abstract PS16-01: Longitudinal validation in the UK Biobank of a breast cancer risk assessment tool that combines a polygenic score for all ancestries with traditional risk factors

Timothy C. Simmons, Elisha Hughes, Srikanth Jammulapati, Dmitry Pruss et autres

Abstract Background: Polygenic risk scores (PRS) have been shown to improve predictive accuracy when incorporated into traditional breast cancer (BC) risk assessment tools. However, most PRS have demonstrated suboptimal performance among women of non-European ancestry. We improved a previously reported multiple-ancestry PRS …

Association of an ancestry-specific variant near the ESR1 gene with cancer risk and breast density in women of self-reported Hispanic ancestry.

Elisha Hughes, Allison W. Kurian, Eudora Hu, Matthew T. Kucera et autres

10513 Background: A single-nucleotide polymorphism (SNP), rs140068132, located in the 6q25 region near the ESR1 gene, is common in self-reported Hispanic women but rare or absent in other populations. Previous studies have shown that rs140068132 is associated with a significantly reduced risk …

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O04: Longitudinal validation in UK Biobank of a breast cancer risk model combining a multiple-ancestry polygenic score with traditional risk factors

Elisha Hughes, Srikanth Jammulapati, Dmitry Pruss, Eudora Hu et autres

Current Concepts in Menopausal Hormone Therapy and Breast Cancer

Juliana M. Kling, Holly Jane Pederson

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Germline Genetic Susceptibility Testing Among Emirati Nationals at Risk for Hereditary Breast and Ovarian Cancer Syndrome

Rifaat R. Rawashdeh, Holly Jane Pederson, Rafal R Iskanderian, Fawad Ahmad Khan et autres

PURPOSE: Breast cancer among Emirati patients is characterized by early-onset disease and later stages at presentation. Little is known about the germline genetic variants that may contribute to these observations. The goal of this study is to characterize the rate and implications …

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