R. Chen

A pre-train and fine-tune framework for adaptive boosting of pre-trained polygenic risk scores

Jie Hu, R. Chen, Maxwell Salvatore, Olivia Wu et autres

Polygenic risk scores are widely used for predicting genetic risk across complex diseases and traits, and several pre-trained models have been developed. Few approaches leverage these pre-trained polygenic risk scores to further refine predictive performance. Here, we present Adaptive Boosting of pre-trained …

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A Pre-train and Fine-tune Framework for Adaptively Boosting Polygenic Risk Prediction

Ruowang Li, Hu Jie, R. Chen, Olivia Wu et autres

Polygenic risk scores (PRSs) are widely used for predicting genetic risk across complex diseases and traits, with thousands of pre-trained models constructed using diverse methodologies and data sources. Despite their widespread utility, limited approaches leverage these pre-trained PRS to further refine their …

A Pre-train and Fine-tune Framework for Adaptively Boosting Polygenic Risk Prediction

Ruowang Li, Hu Jie, R. Chen, Olivia Wu et autres

Polygenic risk scores (PRSs) are widely used for predicting genetic risk across complex diseases and traits, with thousands of pre-trained models constructed using diverse methodologies and data sources. Despite their widespread utility, limited approaches leverage these pre-trained PRS to further refine their …

G2DBridge: A Multimodal Framework Linking Genetics to Disease through Imaging Intermediates

Okan B Ozdemir, R. Chen, Olivia Wu, Ruowang Li

Genetic-based risk prediction is becoming increasingly available for a wide range of common diseases thanks to the growth of large-scale biobanks and population-scale genetic studies. However, despite widespread availability, genetic risk prediction typically offers only modest predictive power, as complex biological processes …

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A deep ensemble encoder network method for improved polygenic risk score prediction

Okan Bilge Özdemir, R. Chen, Olivia Wu, Ruowang Li

Genome-wide association studies of various heritable human traits and diseases have identified numerous associated single-nucleotide polymorphisms (SNPs), most of which have small or modest effects. Polygenic risk scores aim to better estimate individuals’ genetic predisposition by aggregating the effects of multiple SNPs …

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Investigate the Effects of Preeclampsia Severity, Race and Fetal Sex on Subsequent Maternal Complications Using EHR Data From Over 100,000 Pregnancies

Xiaotong Yang, Haoming Zhu, Leyang Tao, R. Chen et autres

ABSTRACT Preeclampsia (PE) is a major pregnancy complication associated with long‐term maternal health risks, but how these risks vary by severity, race, and fetal sex is unclear. To identify maternal complications after PE and to evaluate the modifying effects of severity, race, …

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Beyond P-values: A Multi-Metric Framework for Robust Feature Selection and Predictive Modeling

R. Chen, Attri Ghosh, Jie Hu, Jason H. Moore et autres

High-dimensional biomedical datasets routinely contain sparse signals embedded among vast, correlated features, making variable selection central to building models that generalize. Although significance-based selection is widely used across modalities (e.g., imaging, EHR, multi-omics), statistical significance does not guarantee predictive utility, and vice …

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Chronic phase advance in mice induces behavior despair and suppresses neuroimmune activation potentially via regulation of the HPA axis

R. Chen, Aidan S. Weitzner, Lara A. McKennon, Laura K. Fonken

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Broadband wireless access with WiMax/802.16: current performance benchmarks and future potential

Anumoy Ghosh, Daniel Wolter, Jeffrey G. Andrews, R. Chen

The IEEE 802.16 family of standards and its associated industry consortium, WiMax, promise to deliver high data rates over large areas to a large number of users in the near future. This exciting addition to current broadband options such as DSL, cable, …

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High packing density 2.5 THz true-time-delay lines using spatially multiplexed substrate guided waves in conjunction with volume holograms on a single substrate

R.L.Q. Li, Zhenhai Fu, R. Chen

A 3-bit true-time-delay lines device having a packing density of 5 lincs/cm/sup 2/ with a minimum delay step of /spl sim/100 ps is designed, fabricated and demonstrated. This device is based on substrate guided wave propagation combined with slanted photopolymer volume phase …

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