Yuhui Shen

Epitranscriptomic silencing of STK25 promotes ferroptosis evasion via the METTL3–YAP–GPX4 axis in osteosarcoma

Zhuochao Liu, Zhusheng Zhang, Fangqiong Hu, Junxiang Wen et autres

cn (code pays fourni par la source)

Quantitative morphological profiling and machine learning-based high-throughput classification of interneurons in the mouse neocortex

Li Ke, Yuhui Shen, Mingting Shao, Cuiping Hu et autres

Thoracolumbar vertebral bone quality (TLVBQ) score as a possible screening tool for osteoporosis in patients with severe degenerative lumbar scoliosis: a retrospective cohort study

Wanli Zheng, Songbo Gao, Shuangxing Li, Weitao Han et autres

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Pulmonary metastasectomy and response-adapted preoperative surveillance in resectable metastatic osteosarcoma: a single-center retrospective cohort study with long-term follow-up

Zhusheng Zhang, Tao Liang, Qi Liu, Xiaoqing Yang et autres

Background: Pulmonary metastasectomy remains the standard of care for resectable metastatic osteosarcoma. However, controversy persists regarding minimally invasive surgery versus thoracotomy for occult nodule detection, the optimal use and duration of preoperative systemic therapy and prognostic factors associated with long-term survival. This …

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Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Q.W Yan, Chongchong Xu, Jiangmei Gao, Pu Wang et autres

ABSTRACT Human induced pluripotent stem cell (iPSC)‐derived dopaminergic progenitors offer a promising strategy for cell replacement in Parkinson's disease (PD), yet their long‐term efficacy and safety in primates remain underexplored. Here, we generated isogenic iPSC lines from a PD patient carrying compound …

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An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons

Rui-Feng Liu, Mengyao Huang, Yuhui Shen, Mingting Shao et autres

The anterior insular cortex (AIC) is a critical hub integrating exteroceptive and interoceptive information into high-order cognition, yet its neural basis remains incompletely understood. Here, by combining whole-cell-based single-cell transcriptomics with Patch-seq recordings, we resolved and characterized 78 detailed cell types in …

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Quantitative morphological profiling and machine learning-based high-throughput classification of interneurons in the mouse neocortex

Li Ke, Yuhui Shen, Mingting Shao, Rui-Feng Liu et autres

Stereotactic Body Radiation Therapy Augmented Checkpoint Inhibitor Immunotherapy Response in Heavily Pretreated Metastatic Osteosarcoma

Chuanying Zhu, Yichen Xu, Junxiang Wen, Zhusheng Zhang et autres

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A 32-37 GHz 6-bit CMOS active phase shifter with high accuracy and low insertion loss

Yuhui Shen, Hao Zhang, Jian Guo

A 6-bit active phase shifter operating at 32~37 GHz using a 55nm CMOS process is proposed in this paper. The phase shifter features 360° phase shift, high phase resolution and low gain error. Combination of quadrature all-pass filter (QAF) and interstage transformers …

LPBFuzz: Binary program fuzzing with enhanced coverage of low-frequency program branches

Yuhui Shen, Haoran Zhang, Siyuan Shao, Zhao Zhang

Abstract Fuzzing detects hidden defects and vulnerabilities in software by generating a large amount of malformed input data and monitoring program anomalies. The existing fuzzing methods suffer from data imbalance when modeling program branching behaviors, making it difficult to accurately locate data …

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Multimodal Nature of the Single-cell Primate Brain Atlas: Morphology, Transcriptome, Electrophysiology, and Connectivity

Yuhui Shen, Mingting Shao, Zhao-Zhe Hao, Mengyao Huang et autres

Primates exhibit complex brain structures that augment cognitive function. The neocortex fulfills high-cognitive functions through billions of connected neurons. These neurons have distinct transcriptomic, morphological, and electrophysiological properties, and their connectivity principles vary. These features endow the primate brain atlas with a …

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A primate nigrostriatal atlas of neuronal vulnerability and resilience in a model of Parkinson’s disease

Lei Tang, Nana Xu, Mengyao Huang, Yi Wei et autres

The degenerative process in Parkinson's disease (PD) causes a progressive loss of dopaminergic neurons (DaNs) in the nigrostriatal system. Resolving the differences in neuronal susceptibility warrants an amenable PD model that, in comparison to post-mortem human specimens, controls for environmental and genetic …

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